血液和淋巴疾病

非腫瘤性血液和淋巴疾病包括一系列影響血液成分和淋巴系統(tǒng)功能的狀況，如貧血、凝血障礙、血小板異常、骨髓增生異常綜合征等。這些疾病的治療方法多樣，包括藥物治療、輸血、骨髓移植等。近年來，針對(duì)這些非腫瘤性血液和淋巴疾病的藥物研發(fā)也取得了顯著進(jìn)展。

貧血：貧血是血液中紅細(xì)胞數(shù)量或血紅蛋白含量低于正常水平的疾病。治療貧血的新藥物研發(fā)主要集中在刺激紅細(xì)胞生成的藥物，如紅細(xì)胞生成素（erythropoiesis-stimulating agents, ESAs）。ESAs通過模擬內(nèi)源性紅細(xì)胞生成素的作用，促進(jìn)紅細(xì)胞的產(chǎn)生，用于治療慢性腎臟病引起的貧血。
凝血障礙：凝血障礙是指血液凝固過程受到影響的疾病，如血友病。在這一領(lǐng)域，新藥物的研發(fā)主要集中在替代療法和基因療法。例如，重組凝血因子的開發(fā)為血友病患者提供了有效的替代治療。此外，基因療法的研究也在不斷進(jìn)展，旨在通過修復(fù)或替換有缺陷的基因來治療凝血障礙。
血小板異常：血小板異常疾病包括血小板數(shù)量減少或功能異常，如免疫性血小板減少性紫癜（ITP）。治療ITP的新藥物，如血小板生成素受體激動(dòng)劑（thrombopoietin receptor agonists, TPO-RAs），通過模擬血小板生成素的作用，增加血小板的產(chǎn)生，從而減少出血風(fēng)險(xiǎn)。
骨髓增生異常綜合征：骨髓增生異常綜合征是一組骨髓細(xì)胞異常增生的疾病，可能導(dǎo)致貧血、出血傾向和感染風(fēng)險(xiǎn)增加。目前，治療這些疾病的新藥物研發(fā)包括免疫調(diào)節(jié)劑和靶向治療藥物。例如，免疫抑制劑如環(huán)孢素和他克莫司可用于治療某些類型的骨髓增生異常綜合征。

血液和淋巴疾病藥物靶點(diǎn)

血液和淋巴疾病靶點(diǎn)相關(guān)產(chǎn)品推薦

● 靶點(diǎn)蛋白

MS4A1 (CD20)
CSB-MP015007HU

Measured by its binding ability in a functional ELISA. Immobilized human CD20 at 2 μg/ml can bind Anti-CD20 recombinant antibody (CSB-RA015007A1HU), the EC₅₀ is 3.243-7.085 ng/mL

TNFRSF17
CSB-MP023974HU1

Human TNFSF13B protein Fc tag (CSB-MP897523HU1) captured on COOH chip can bind Human BCMA protein Fc tag (CSB-MP023974HU1) with an affinity constant of 39 nM as detected by LSPR Assay.

CD22
CSB-MP004900HU

Measured by its binding ability in a functional ELISA. Immobilized CD22 at 2 μg/ml can bind Anti-CD22 rabbit monoclonal antibody, the EC₅₀ of human CD22 protein is 4.034-4.800 ng/ml.

PDCD1
CSB-MP619964HU1

Measured by its binding ability in a functional ELISA. Immobilized PD-1 at 2 μg/ml can bind Anti-PD-1 recombinant antibody, the EC₅₀ of human PD-1 protein is 6.087-7.854 ng/ml.

CD47
CSB-MP004940HU

Human SIRPA protein His/Myc tag (CSB-MP021334HU) captured on COOH chip can bind Human CD47 protein Fc tag (CSB-MP004940HU) with an affinity constant of 19.1 nM as detected by LSPR Assay.

CD33
CSB-MP004925HU

Measured by its binding ability in a functional ELISA. Immobilized CD33 at 2 μg/ml can bind Anti-CD33 rabbit monoclonal antibody, the EC₅₀ of human CD33 protein is 4.289- 5.312 ng/ml.

CD274
CSB-MP878942HU1

Measured by its binding ability in a functional ELISA. Immobilized PD-L1 at 2 μg/ml can bind Anti- PD-L1 mouse monoclonal antibody(CSB-MA878942A1m, antigen from E.coli), the EC₅₀ of human PD-L1 protein is 1.252-1.653 ng/mL

TNFRSF8
CSB-MP023983HU1

Measured by its binding ability in a functional ELISA. Immobilized CD30 at 5 μg/ml can bind human CD30L (CSB-MP023996HU1c9), the EC₅₀ is 14.96-20.25 ng/ml

產(chǎn)品名稱	貨號(hào)	靶點(diǎn)	來源	蛋白標(biāo)簽
Recombinant Human B-lymphocyte antigen CD19 (CD19), partial (Active)	CSB-AP005061HU	CD19	Mammalian cell	C-terminal Fc-tagged
Recombinant Human B-cell receptor CD22 (CD22), partial (Active)	CSB-MP004900HU	CD22	Mammalian cell	C-terminal 6xHis-tagged
Recombinant Human Programmed cell death 1 ligand 1 (CD274), partial (Active)	CSB-MP878942HU1	CD274	Mammalian cell	C-terminal hFc-tagged
Recombinant Human Myeloid cell surface antigen CD33 (CD33), partial (Active)	CSB-MP004925HU	CD33	Mammalian cell	C-terminal hFc-Myc-tagged
Recombinant Human Tumor necrosis factor receptor superfamily member 5 (CD40), partial (Active)	CSB-AP005181HU	CD40	Mammalian cell	C-terminal Fc-tagged
Recombinant Human Tumor necrosis factor receptor superfamily member 5 (CD40), partial (Active)	CSB-MP004936HU1	CD40	Mammalian cell	C-terminal hFc-tagged
Recombinant Human CD40 ligand (CD40LG), partial (Active)	CSB-AP005191HU	CD40LG	E.coli	Tag-Free
Recombinant Human CD40 ligand (CD40LG), partial (Active)	CSB-MP004937HU3	CD40LG	Mammalian cell	N-terminal hFc-Flag-tagged
Recombinant Human Leukocyte surface antigen CD47 (CD47), partial (Active)	CSB-AP005201HU	CD47	Mammalian cell	C-terminal 6xHis-tagged
Recombinant Human Leukocyte surface antigen CD47 (CD47), partial (Active)	CSB-AP005211HU	CD47	Mammalian cell	C-terminal Fc-tagged
Recombinant Human Leukocyte surface antigen CD47 (CD47), partial (Active)	CSB-MP004940HU	CD47	Mammalian cell	C-terminal hFc-tagged
Recombinant Human T-cell antigen CD7 (CD7), partial (Active)	CSB-MP004953HU	CD7	Mammalian cell	C-terminal hFc-Myc-tagged
Recombinant Human CD70 antigen (CD70), partial (Active)	CSB-MP004954HU1	CD70	Mammalian cell	N-terminal 10xHis-tagged
Recombinant Human Granulocyte-macrophage colony-stimulating factor (CSF2) (Active)	CSB-AP003581HU	CSF2	E.coli	Tag-Free
Recombinant Human Granulocyte-macrophage colony-stimulating factor (CSF2) (Active)	CSB-AP003601HU	CSF2	Mammalian cell	C-terminal 6xHis-tagged
Recombinant Mouse Granulocyte-macrophage colony-stimulating factor (Csf2) (Active)	CSB-AP003651MO	Csf2	Mammalian cell	C-terminal 6xHis-tagged
Recombinant Mouse Granulocyte-macrophage colony-stimulating factor (Csf2) (Active)	CSB-AP003661MO	Csf2	E.coli	Tag-Free
Recombinant Human Granulocyte-macrophage colony-stimulating factor receptor subunit alpha (CSF2RA), partial (Active)	CSB-AP003591HU	CSF2RA	Mammalian cell	C-terminal 6xHis-tagged
Recombinant Guinea pig Cytotoxic T-lymphocyte associated protein 4 (CTLA4), partial (Active)	CSB-AP005121GU	CTLA4	Yeast	C-terminal 6xHis-tagged
Recombinant Human Cytotoxic T-lymphocyte protein 4 (CTLA4), partial (Active)	CSB-AP005231HU	CTLA4	Mammalian cell	C-terminal 6xHis-tagged

● 穩(wěn)定細(xì)胞株

CT26/Human ROR1 Stable Cell Line

CSB-SC020067HU

Untransfected CT26 cells (green line) and transfected Human ROR1 CT26 stable cells (red line) were stained with anti-ROR1 antibody (CSB-RA020067A1HU) (2μg/1*10⁶ cells), washed and then followed by FITC-conjugated anti-Human IgG Fc antibody and analyzed with flow cytometry.

● 重組抗體

ALB Recombinant Monoclonal Antibody
CSB-RA264109A0HU

Overlay Peak curve showing HepG2 cells stained with CSB-RA264109A0HU (red line) at 1:50.

CD274 Recombinant Monoclonal Antibody
CSB-RA878942MA1HU

Overlay Peak curve showing Hela cells surface stained with CSB-RA878942MA1HU (red line) at 1:100.

CD3E Recombinant Monoclonal Antibody
CSB-RA004931MA1HU

Overlay Peak curve showing JK cells surface stained with CSB-RA004931MA1HU (red line) at 1:100.

TOP1 Recombinant Monoclonal Antibody
CSB-RA792129A0HU

Overlay histogram showing HepG2 cells stained with CSB-RA792129A0HU (red line) at 1:50.

產(chǎn)品名稱	貨號(hào)	靶點(diǎn)	反應(yīng)種屬	應(yīng)用范圍
ALB Recombinant Monoclonal Antibody	CSB-RA264109A0HU	ALB	Human	ELISA, FC
C3 Recombinant Monoclonal Antibody	CSB-RA303909A0HU	C3	Human	ELISA, WB, IHC, FC
C3 Recombinant Monoclonal Antibody	CSB-RA699863A0HU	C3	Human	ELISA, IHC
C5 Recombinant Monoclonal Antibody	CSB-RA003995MA1HU	C5	Human	ELISA, FC
CD19 Recombinant Monoclonal Antibody	CSB-RA004888A0HU	CD19	Human	ELISA
CD19 Recombinant Monoclonal Antibody	CSB-RA780821A0HU	CD19	Human	ELISA, WB, IHC, IP
CD19 Recombinant Monoclonal Antibody	CSB-RA004888MA1HU	CD19	Human, Mouse	ELISA, WB
CD22 Recombinant Monoclonal Antibody	CSB-RA962691A0HU	CD22	Human	ELISA, IHC
CD247 Recombinant Monoclonal Antibody	CSB-RA244537A0HU	CD247	Human	ELISA, FC
CD274 Recombinant Monoclonal Antibody	CSB-RA977797A0HU	CD274	Human	ELISA, WB, IHC
CD274 Recombinant Monoclonal Antibody	CSB-RA878942MA1HU	CD274	Human	ELISA, IHC, FC
CD34 Recombinant Monoclonal Antibody	CSB-RA004926A0HU	CD34	Human	ELISA, IHC
CD38 Recombinant Monoclonal Antibody	CSB-RA796695A0HU	CD38	Human	ELISA, WB, IHC
CD3E Recombinant Monoclonal Antibody	CSB-RA004931MA1HU	CD3E	Human	ELISA, FC
CD4 Recombinant Monoclonal Antibody	CSB-RA004935A0HU	CD4	Human	ELISA, WB, IHC
CD40 Recombinant Monoclonal Antibody	CSB-RA004936MA1HU	CD40	Human	ELISA, IF, FC
CD47 Recombinant Monoclonal Antibody	CSB-RA802124A0HU	CD47	Human	ELISA, WB, IHC, IF
CD70 Recombinant Monoclonal Antibody	CSB-RA004954MA1HU	CD70	Human	ELISA
CD80 Recombinant Monoclonal Antibody	CSB-RA246383A0HU	CD80	Human	ELISA, WB, IHC, IP
CTLA4 Recombinant Monoclonal Antibody	CSB-RA213310A0HU	CTLA4	Human	ELISA, IHC

● ELISA試劑盒

產(chǎn)品名稱	貨號(hào)	靶點(diǎn)	檢測(cè)范圍	靈敏度
Bovine Albumin(Alb) ELISA kit	CSB-E08664b	ALB	0.313 μg/mL-80 μg/mL	0.148 μg/mL
Mouse Albumin (Alb)ELISA Kit	CSB-E13878m	ALB	0.781 μg/mL-200 μg/mL	0.110 μg/mL
Dog Albumin(Alb) ELISA Kit	CSB-E15757c	ALB	0.273 μg/mL-35 μg/mL	0.266 μg/mL
Sheep Albumin (Alb)ELISA Kit	CSB-E15839Sh	ALB	350 μg/mL-21.88 μg/mL	5.5 μg/mL
Horse Albumin(Alb) ELISA Kit	CSB-E16205Hs	ALB	1.25 μg/mL-80 μg/mL	1.247 μg/mL
Pig Albumin (Alb) ELISA Kit	CSB-E16207p	ALB	0.03 μg/mL-7000 μg/mL	0.03 μg/mL
Goat Albumin (Alb)ELISA Kit	CSB-E15758G	ALB	0.17 μg/mL-350 μg/mL	0.17 μg/mL
Guinea Pig Albumin(Alb) ELISA kit	CSB-E15765Gp	ALB	0.156 μg/mL-10 μg/mL	0.09 μg/mL
Rabbit Albumin(Alb) ELISA Kit	CSB-E16204Rb	ALB	0.273 μg/mL-70 μg/mL	0.117 μg/mL
Human Complement 3,C3 ELISA Kit	CSB-E08665h	C3	4.7 ng/mL-300 ng/mL	4.031 ng/mL
Pig Complement 3,C3 ELISA Kit	CSB-E06920p	C3	0.625 μg/mL-10 μg/mL	0.625 μg/mL
Rat Complement 3,C3 ELISA Kit	CSB-E08666r	C3	0.625 μg/mL-40 μg/mL	0.156 μg/mL
Mouse Complement 3,C3 ELISA Kit	CSB-E08667m	C3	93.75 ng/mL-6000 ng/mL	23.44 ng/mL
Rabbit Complement 3,C3 ELISA Kit	CSB-E08668Rb	C3	27.3 ng/mL-7000 ng/mL	27.3 ng/mL
Fish Complement 3,C3 ELISA Kit	CSB-E09727s	C3	12.5 μg/mL-500 μg/mL	12.5 μg/mL
Monkey Complement 3(C3)ELISA Kit	CSB-E16528Mk	C3	4.68 ng/mL-300 ng/mL	1.17 ng/mL
Dog Complement 3(C3)ELISA Kit	CSB-EL003888DO	C3	0.78 μg/mL-50 μg/mL	0.195 μg/mL
Mouse Complement 5,C5 ELISA Kit	CSB-E13802m	C5	0.25 ng/mL-16 ng/mL	0.06 ng/mL
Rat Complement fragment 5,C5 ELISA Kit	CSB-E14363r	C5	9.38 ng/mL-600 ng/mL	2.34 ng/mL
Monkey complement C5 (C5) ELISA kit	CSB-EL003995MK	C5	0.625 ng/mL-40 ng/mL	0.156 ng/mL