FCGR3A
FCGR3A，全稱低親和力免疫球蛋白γ Fc區受體III-A，常見別名為CD16a、FCGR3，是IgG Fc片段的受體，主要表達在自然殺傷細胞、巨噬細胞等免疫細胞表面。該蛋白參與抗體依賴性細胞介導的細胞毒性和病毒感染的抗體依賴性增強，通過與IgG結合激活NK細胞等效應細胞，發揮免疫調節作用。FCGR3A在腫瘤免疫治療中具有重要應用，例如靶向HER2的抗體藥物優化的Fc結構域可增強與FCGR3A的親和力，提高抗體介導的細胞毒殺傷效應。目前，多款靶向FCGR3A的藥物正在研發中，包括單克隆抗體、雙特異性抗體等，用于治療腫瘤、自身免疫性疾病等。例如，再鼎醫藥的馬吉妥昔單抗注射液通過優化Fc結構域，增強對FCGR3A的親和力，提高抗腫瘤療效；信達生物的CD40L抗體IBI355則用于調節免疫細胞活性，治療系統性紅斑狼瘡等疾病。這些進展表明FCGR3A是重要的免疫治療靶點，未來有望開發更多基于該靶點的創新藥物。
熱銷產品
驗證數據
-SDS.jpg)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
-AC1.jpg)
Activity
Loaded Anti-Human CD16a Antibody (CSB-RA008543MA1HU) on 96-Flat plate, can bind Human CD16a(F176V), with an affinity constant of 12 nM as determined in BLI assay (Gator Prime).
FCGR3A Recombinant Monoclonal Antibody (CSB-RA008543MA1HU)
驗證數據
Immunofluorescence staining of Hela cell with CSB-RA008543MA1HU at 1:30, counter-stained with DAPI. The cells were fixed in 4% formaldehyde and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
The Binding Activity of Rat Gcgr with Anti-Gcgr Recombinant Antibody
Activity: Measured by its binding ability in a functional ELISA. Immobilized Rat Gcgr (CSB-MP009316RA1) at 2 μg/mL can bind Anti-Gcgr recombinant antibody. The EC50 is 29.63-35.34 ng/m
The Binding Activity of Human FCGR3A with Anti-FCGR3A Recombinant Antibody
Activity: Measured by its binding ability in a functional ELISA. Immobilized Human FCGR3A (CSB-MP008543HU1) at 2 μg/mL can bind Anti-FCGR3A recombinant antibody. The EC50 is 0.2330-0.3147 ng/mL.
Human Low affinity immunoglobulin gamma Fc region receptor III-A(FCGR3A) ELISA kit (CSB-EL008543HU)
驗證數據
貨號：CSB-EL008543HU
規格：96T/48T
靈敏度：11.75 pg/mL
檢測范圍：47 pg/mL-3000 pg/mL
These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
FCGR3A Antibodies
FCGR3A for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 種屬反應性 | 應用類型 |
|---|---|---|---|
| CSB-PA287660 | FCGR3A Antibody | Human | ELISA,IHC |
| CSB-PA183080 | FCGR3A Antibody | Human | ELISA,IHC |
| CSB-PA008543LA01HU | FCGR3A Antibody | Human | ELISA, IHC, IF |
| CSB-PA008543LB01HU | FCGR3A Antibody, HRP conjugated | Human | ELISA |
| CSB-PA008543LC01HU | FCGR3A Antibody, FITC conjugated | Human | |
| CSB-PA008543LD01HU | FCGR3A Antibody, Biotin conjugated | Human | ELISA |
| CSB-RA008543MA1HU | FCGR3A Recombinant Monoclonal Antibody | Human, Rat | ELISA, IF |
FCGR3A Proteins
FCGR3A Proteins for Homo sapiens (Human)
FCGR3A Proteins for Bos taurus (Bovine)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP303590BO CSB-EP303590BO CSB-BP303590BO CSB-MP303590BO CSB-EP303590BO-B |
Recombinant Bovine Low affinity immunoglobulin gamma Fc region receptor III (FCGR3), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
FCGR3A Proteins for Macaca mulatta (Rhesus macaque)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP388701MOW CSB-EP388701MOW CSB-BP388701MOW CSB-MP388701MOW CSB-EP388701MOW-B |
Recombinant Macaca mulatta Low affinity immunoglobulin gamma Fc region receptor III (FCGR3), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
FCGR3A Proteins for Sus scrofa (Pig)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP636747PI CSB-EP636747PI CSB-BP636747PI CSB-MP636747PI CSB-EP636747PI-B |
Recombinant Pig Low affinity immunoglobulin gamma Fc region receptor III (FCGR3), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
FCGR3A Proteins for Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP854680MOV CSB-EP854680MOV CSB-BP854680MOV CSB-MP854680MOV CSB-EP854680MOV-B |
Recombinant Macaca fascicularis Low affinity immunoglobulin gamma Fc region receptor III (FCGR3), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
FCGR3A ELISA Kit
FCGR3A ELISA Kit for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-EL008543HU | Human Low affinity immunoglobulin gamma Fc region receptor III-A(FCGR3A) ELISA kit | serum, plasma, tissue homogenates | 11.75 pg/mL |
