甲狀腺癌

甲狀腺癌是一種起源于甲狀腺的惡性腫瘤，甲狀腺位于頸部底部，負(fù)責(zé)生產(chǎn)調(diào)節(jié)新陳代謝的激素。甲狀腺癌的發(fā)病率在全球范圍內(nèi)呈上升趨勢，但其死亡率保持相對穩(wěn)定，這可能與早期診斷和治療技術(shù)的進(jìn)步有關(guān)。

甲狀腺癌的預(yù)后受多種因素影響，包括病理類型、治療效果和患者的整體健康狀況。乳頭狀癌是最常見的類型，通常預(yù)后較好，而未分化癌和甲狀腺髓樣癌的預(yù)后較差。

甲狀腺癌傳統(tǒng)的治療手段包括手術(shù)、放射性碘治療和甲狀腺素替代治療。對于晚期或難治性甲狀腺癌，近年來分子靶向治療和免疫治療的研究取得了顯著進(jìn)展。

分子靶向治療：分子靶向治療通過抑制腫瘤生長和擴散的特定分子通路來治療癌癥。例如，索拉非尼是第一個被FDA批準(zhǔn)用于治療進(jìn)展性放射性碘難治性分化型甲狀腺癌（RR-DTC）的分子靶向藥物。此外，RET抑制劑塞爾帕替尼在治療RET突變型甲狀腺髓樣癌（MTC）中表現(xiàn)出顯著的療效。
免疫治療：免疫治療通過激活或增強患者的免疫系統(tǒng)來攻擊腫瘤細(xì)胞。雖然目前關(guān)于GLP-1RAs和DPP-4i藥物的使用與甲狀腺癌風(fēng)險之間的關(guān)系仍存在爭議，但免疫檢查點抑制劑等免疫治療方法在甲狀腺癌治療中正受到關(guān)注。

甲狀腺癌藥物靶點

甲狀腺癌藥物靶點相關(guān)產(chǎn)品推薦

● 靶點蛋白

PDCD1
CSB-MP619964HU1

Measured by its binding ability in a functional ELISA. Immobilized PD-1 at 2 μg/ml can bind Anti-PD-1 recombinant antibody, the EC₅₀ of human PD-1 protein is 6.087-7.854 ng/ml.

ERBB2
CSB-MP007763HU

Measured by its binding ability in a functional ELISA. Immobilized HER2 at 2 μg/ml can bind Trastuzumab, the EC₅₀ is 2.179-2.825 ng/ml.

CD276
CSB-MP733578HU

Measured by its binding ability in a functional ELISA. Immobilized CD276 at 2 μg/ml can bind Anti-CD276 rabbit monoclonal antibody, the EC₅₀ of human CD276 protein is 1.961-2.243 ng/ml.

CEACAM5
CSB-MP005165HU

Measured by its binding ability in a functional ELISA. Immobilized Human CEACAM5 at 2μg/mL can bind Anti-CEACAM5 recombinant antibody (CSB-RA005165MA1HU), the EC₅₀ is 0.8955-1.719 ng/mL.

CTLA4
CSB-MP006163HU1

Measured by its binding ability in a functional ELISA. Immobilized CD152 at 2 μg/ml can bind Anti-CD152 rabbit monoclonal antibody (CSB-RA213310A0HU), the EC₅₀ of human CD152 protein is 27.14-34.82 ng/ml.

DLL3
CSB-MP882142HU

Measured by its binding ability in a functional ELISA. Immobilized DLL3 at 2 μg/ml can bind Anti-DLL3 Recombinant Antibody（CSB-RA882142A1HU）, the EC⁵⁰ is 1.102-1.707 ng/mL.

ERBB3
CSB-MP007765HU

Measured by its binding ability in a functional ELISA. Immobilized NRG1 (CSB-MP016077HU1(F6)) at 2 μg/ml can bind human ERBB3, the EC₅₀ is 12.32-15.74 ng/ml.

CD274
CSB-MP878942HU1

Measured by its binding ability in a functional ELISA. Immobilized PD-L1 at 2 μg/ml can bind Anti- PD-L1 mouse monoclonal antibody(CSB-MA878942A1m, antigen from E.coli), the EC₅₀ of human PD-L1 protein is 1.252-1.653 ng/mL

產(chǎn)品名稱	貨號	靶點	來源	蛋白標(biāo)簽
Recombinant Human Programmed cell death 1 ligand 1 (CD274), partial (Active)	CSB-MP878942HU1	CD274	Mammalian cell	C-terminal hFc-tagged
Recombinant Human CD276 antigen (CD276), partial (Active)	CSB-MP733578HU	CD276	Mammalian cell	C-terminal hFc-Myc-tagged
Recombinant Human Carcinoembryonic antigen-related cell adhesion molecule 5 (CEACAM5) (E398K) (Active)	CSB-MP005165HU	CEACAM5	Mammalian cell	C-terminal 10xHis-tagged
Recombinant Guinea pig Cytotoxic T-lymphocyte associated protein 4 (CTLA4), partial (Active)	CSB-AP005121GU	CTLA4	Yeast	C-terminal 6xHis-tagged
Recombinant Human Cytotoxic T-lymphocyte protein 4 (CTLA4), partial (Active)	CSB-AP005231HU	CTLA4	Mammalian cell	C-terminal 6xHis-tagged
Recombinant Mouse Cytotoxic T-lymphocyte protein 4 (Ctla4), partial (Active)	CSB-AP005301MO	Ctla4	Mammalian cell	C-terminal 6xHis-tagged
Recombinant Human Cytotoxic T-lymphocyte protein 4 (CTLA4), partial (Active)	CSB-MP006163HU1	CTLA4	Mammalian cell	C-terminal hFc-tagged
Recombinant Human Delta-like protein 3 (DLL3), partial (Active)	CSB-MP882142HU	DLL3	Mammalian cell	C-terminal 6xHis-tagged
Recombinant Macaca fascicularis Delta-like protein 3 (DLL3), partial (Active)	CSB-MP3536MOV	DLL3	Mammalian cell	C-terminal 6xHis-tagged
Recombinant Human Receptor tyrosine-protein kinase erbB-2 (ERBB2), partial (Active)	CSB-MP007763HU	ERBB2	Mammalian cell	C-terminal 6xHis-tagged
Recombinant Human Receptor tyrosine-protein kinase erbB-3 (ERBB3), partial (Active)	CSB-MP007765HU	ERBB3	Mammalian cell	C-terminal hFc-tagged
Recombinant Human Interleukin-15 receptor subunit alpha (IL15RA), partial (Active)	CSB-AP004551HU	IL15RA	Mammalian cell	C-terminal Fc-tagged
Recombinant Mouse Interleukin-15 receptor subunit alpha (Il15ra), partial (Active)	CSB-AP004801MO	Il15ra	Mammalian cell	C-terminal Fc-tagged
Recombinant Human Programmed cell death protein 1 (PDCD1), partial (Active)	CSB-MP619964HU1	PDCD1	Mammalian cell	C-terminal 6xHis-tagged
Recombinant Human Tumor-associated calcium signal transducer 2 (TACSTD2), partial (Active)	CSB-MP023072HU1	TACSTD2	Mammalian cell	C-terminal hFc-tagged
Recombinant Human Tumor-associated calcium signal transducer 2 (TACSTD2), partial (Active)	CSB-MP023072HU2	TACSTD2	Mammalian cell	C-terminal 10xHis-tagged
Recombinant Human Tumor-associated calcium signal transducer 2 (TACSTD2), partial (Active)	CSB-MP023072HU1d7	TACSTD2	Mammalian cell	C-terminal 10xHis-tagged
Recombinant Human Tumor necrosis factor receptor superfamily member 1A (TNFRSF1A), partial (Active)	CSB-MP023977HU1	TNFRSF1A	Mammalian cell	C-terminal hFc-tagged
Recombinant Human Tumor necrosis factor ligand superfamily member 11 (TNFSF11), partial (Active)	CSB-AP004851HU	TNFSF11	E.coli	Tag free

● 穩(wěn)定細(xì)胞株

HEK293F/Human DLL3 Stable Cell Line

CSB-SC007681HU

Untransfected HEK293 cells (green line) and transfected Human DLL3 HEK293 stable cells (red line) were stained with anti-DLL3 antibody (rovalpituzumab-like) (2μg/1*10⁶ cells), washed and then followed by FITC-conjugated anti-Human IgG1 Fc antibody and analyzed with flow cytometry.

● 重組抗體

CEACAM5 Recombinant Monoclonal Antibody
CSB-RA005165MA3HU

Overlay Peak curve showing Hela cells surface stained with CSB-RA005165MA3HU (red line) at 1:100.

CTLA4 Recombinant Monoclonal Antibody
CSB-RA006163MA1HU

Overlay Peak curve showing JK cells surface stained with CSB-RA006163MA1HU (red line) at 1:50.

DLL3 Recombinant Monoclonal Antibody
CSB-RA882142A1HU

Untransfected HEK293 cells surface (green line) and transfected Human DLL3 HEK293 stable cells surface (red line) were stained with anti-DLL3 antibody (rovalpituzumab-like) (2μl/1*10⁶ cells).

EPCAM Recombinant Monoclonal Antibody
CSB-RA007717MA1HU

Overlay Peak curve showing MCF7 cells surface stained with CSB-RA007717MA1HU (red line) at 1:100.

產(chǎn)品名稱	貨號	靶點	反應(yīng)種屬	應(yīng)用范圍
CD274 Recombinant Monoclonal Antibody	CSB-RA977797A0HU	CD274	Human	ELISA, WB, IHC
CD274 Recombinant Monoclonal Antibody	CSB-RA878942MA1HU	CD274	Human	ELISA, IHC, FC
CD3E Recombinant Monoclonal Antibody	CSB-RA004931MA1HU	CD3E	Human	ELISA, FC
CEACAM1 Recombinant Monoclonal Antibody	CSB-RA147192A0HU	CEACAM1	Human	ELISA, IHC
CEACAM5 Recombinant Monoclonal Antibody	CSB-RA005165MA3HU	CEACAM5	Human	ELISA, IF, FC
CEACAM5 Recombinant Monoclonal Antibody	CSB-RA005165MA1HU	CEACAM5	Human	ELISA
CTLA4 Recombinant Monoclonal Antibody	CSB-RA213310A0HU	CTLA4	Human	ELISA, IHC
CTLA4 Recombinant Monoclonal Antibody	CSB-RA006163MA1HU	CTLA4	Human, Mouse	ELISA, WB, IF, FC
DLL3 Recombinant Monoclonal Antibody	CSB-RA882142A1HU	DLL3	Human	ELISA, FC
EPCAM Recombinant Monoclonal Antibody	CSB-RA932207A0HU	EPCAM	Human	ELISA, WB
EPCAM Recombinant Monoclonal Antibody	CSB-RA439934A0HU	EPCAM	Human	ELISA, WB, IHC
EPCAM Recombinant Monoclonal Antibody	CSB-RA007717MA1HU	EPCAM	Human	ELISA, IHC, FC
ERBB2 Recombinant Monoclonal Antibody	CSB-RA260392A0HU	ERBB2	Human	ELISA, IHC, IF
ERBB2 Recombinant Monoclonal Antibody	CSB-RA007763MA1HU	ERBB2	Human	ELISA
Phospho-ERBB2 (Y1139) Recombinant Monoclonal Antibody	CSB-RA588766A0HU	ERBB2	Human	ELISA, IHC, IF
ERBB2 Recombinant Monoclonal Antibody	CSB-RA007763MA2HU	ERBB2	Human	ELISA, IHC
ERBB3 Recombinant Monoclonal Antibody	CSB-RA937008A0HU	ERBB3	Human	ELISA, IF
FAS Recombinant Monoclonal Antibody	CSB-RA252392A0HU	FAS	Human	ELISA, WB, IHC
ICAM1 Recombinant Monoclonal Antibody	CSB-RA162789A0HU	ICAM1	Human	ELISA, IHC, FC
IGF1R Recombinant Monoclonal Antibody	CSB-RA011087MA1HU	IGF1R	Human	ELISA, FC
PDCD1 Recombinant Monoclonal Antibody	CSB-RA240597A0HU	PDCD1	Human	ELISA, WB, IHC
PGF Recombinant Monoclonal Antibody	CSB-RA280380A0HU	PGF	Human	ELISA, IHC
TOP1 Recombinant Monoclonal Antibody	CSB-RA792129A0HU	TOP1	Human	ELISA, WB, IHC, FC, IP

● ELISA試劑盒

產(chǎn)品名稱	貨號	靶點	檢測范圍	靈敏度
Mouse Vascular Endothelial cell Growth Factor B,VEGF-B ELISA kit	CSB-E07365m	VEGFB	7.8 pg/mL-500 pg/mL	0.195 pg/mL
Human Vascular Endothelial cell Growth Factor B,VEGF-B ELISA KIT	CSB-E04758h	VEGFB	15.6 pg/mL-1000 pg/mL	3.9 pg/mL
Bovine Vascular endothelial growth factor A(VEGFA) ELISA kit	CSB-EL025833BO	VEGFA	47 pg/mL-3000 pg/mL	11.75 pg/mL
Pig Vascular Endothelial cell Growth Factor,VEGF ELISA KIT	CSB-E12053p	VEGFA	4.69 pg/mL-300 pg/mL	1.17 pg/mL
Dog Vascular Endothelial cell Growth Factor,VEGF ELISA KIT	CSB-E11744c	VEGFA	3.12 pg/mL-200 pg/mL	0.78 pg/mL
Rat Vascular Endothelial cell Growth Factor,VEGF ELISA Kit	CSB-E04757r	VEGFA	3.9 pg/mL-250 pg/mL	0.97 pg/mL
Human Vascular Endothelial cell Growth Factor(VEGF) ELISA KIT	CSB-E11718h	VEGFA	31.25 pg/mL-2000 pg/mL	25.297 pg/mL
Mouse Vascular Endothelial cell Growth Factor,VEGF ELISA KIT	CSB-E04756m	VEGFA	3.906 pg/mL-250 pg/mL	0.857 pg/mL
Mouse soluble receptor activator of nuclear factor-kB ligand,sRANKL ELISA Kit	CSB-E05127m	TNFSF11	12.5 pg/ml-800 pg/ml.	3.12 pg/ml.
Rat soluble receptor activator of nuclear factor-kB ligand,sRANKL ELISA Kit	CSB-E05126r	TNFSF11	62.5 pg/mL-4000 pg/mL	15.6 pg/mL
Human soluble receptor activator of nuclear factor-kB ligand,sRANKL ELISA Kit	CSB-E05125h	TNFSF11	7.8 pg/mL-500 pg/mL	1.95 pg/mL
Mouse Tumor necrosis factor soluble receptor Ⅰ,TNFsR-Ⅰ ELISA KIT	CSB-E04737m	TNFRSF1A	15.625 pg/mL-1000 pg/mL	1.261 pg/mL
Human Tumor necrosis factor soluble receptor Ⅰ,TNFsR-ⅠELISA KIT	CSB-E04736h	TNFRSF1A	78.125 pg/mL-5000 pg/mL	65 pg/mL
Rat placenta growth factor,PLGF ELISA kit	CSB-E07400r	PGF	3.12 pg/mL-200 pg/mL	0.78 pg/mL
Human placenta growth factor,PLGF ELISA kit	CSB-E04707h	PGF	1.67 ng/mL-40 ng/mL	0.7 ng/mL
Human Programmed Death 1(PD-1)ELISA KIT	CSB-E13643h	PDCD1	15.6 pg/mL-1000 pg/mL	3.9 pg/mL
Mouse Programmed Death 1(PD-1)ELISA Kit	CSB-E13586m	PDCD1	0.312 ng/mL-20 ng/mL	0.078 ng/mL
Human Interleukin-15 receptor subunit alpha(IL15RA) ELISA kit	CSB-EL011594HU	IL15RA	31.25 pg/mL-2000 pg/mL	7.8 pg/mL
Rat Insulin-like Growth Factors 1 Receptor,IGF-1R ELISA Kit	CSB-E13873r	IGF1R	3.12 pg/mL-200 pg/mL	0.8 pg/mL
Human insulin-like growth factors 1 receptor,IGF-1R ELISA Kit	CSB-E13766h	IGF1R	0.312 ng/mL-20 ng/mL	0.078 ng/mL