CSF1R
CSF1R，即集落刺激因子1受體，別名CD115、MCSFR、Oncogen FMS、Proto-oncogene c-Fms、V-FMS McDonough feline sarcoma viral oncogen homolog、formerly。它是一種由CSF1R基因編碼的跨膜受體，屬于酪氨酸激酶受體家族成員。CSF1R在多種組織中表達(dá)，尤其在單核-巨噬細(xì)胞系中表達(dá)量較高。CSF1R的作用機(jī)制主要涉及與集落刺激因子1（CSF-1）和白細(xì)胞介素34（IL-34）等配體結(jié)合，激活受體的酪氨酸激酶活性，進(jìn)而引發(fā)細(xì)胞內(nèi)信號(hào)傳導(dǎo)。配體結(jié)合導(dǎo)致受體二聚化和自磷酸化，激活下游的多個(gè)信號(hào)通路，包括PI3K/Akt、MAPK、STAT等。CSF1R參與調(diào)節(jié)單核細(xì)胞、巨噬細(xì)胞、破骨細(xì)胞的增殖、分化和存活。CSF1R信號(hào)通路的激活對(duì)于維持免疫系統(tǒng)和骨骼系統(tǒng)的正常功能至關(guān)重要。此外，CSF1R的功能異常與多種疾病有關(guān)，包括某些類型的癌癥、免疫性疾病和炎癥性疾病。因此，CSF1R是藥物開(kāi)發(fā)和疾病治療中的一個(gè)潛在靶點(diǎn)。
熱銷產(chǎn)品
驗(yàn)證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
驗(yàn)證數(shù)據(jù)
Western Blot analysis of HT29 cells using c-Fms Polyclonal Antibody
Western Blot analysis of HT29 cells using c-Fms Polyclonal Antibody
CSF1R Antibodies
CSF1R for Felis silvestris catus
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA006044LA01CA | CSF1R Antibody | Felis silvestris catus | ELISA |
CSF1R for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA084386 | Phospho-CSF1R (Tyr809) Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-PA924224 | Phospho-CSF1R (Tyr561) Antibody | Human,Mouse | ELISA,WB,IHC |
| CSB-PA202220 | Phospho-CSF1R (Tyr708) Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-PA696464 | CSF1R (Ab-809) Antibody | Human,Mouse | ELISA,WB,IHC,IF |
| CSB-PA152912 | Phospho-CSF1R (Tyr699) Antibody | Human | ELISA,WB |
| CSB-PA940519 | Phospho-CSF1R (Tyr809) Antibody | Human | ELISA,IHC |
| CSB-PA001596 | CSF1R Antibody | Human,Mouse,Rat | WB, ELISA |
| CSB-PA001597 | CSF1R Antibody | Human | WB, IHC, IF, ELISA |
| CSB-PA007328 | Phospho-CSF1R (Y809) Antibody | Human,Mouse,Rat | WB, ELISA |
| CSB-PA007329 | Phospho-CSF1R (Y699) Antibody | Human | WB, ELISA |
| CSB-PA007330 | Phospho-CSF1R (Y708) Antibody | Human,Mouse,Rat | WB, ELISA |
| CSB-PA007331 | Phospho-CSF1R (Y723) Antibody | Human,Mouse,Rat | WB, IHC, ELISA |
| CSB-PA007332 | Phospho-CSF1R (Y561) Antibody | Human,Mouse,Rat | WB, IHC, ELISA |
| CSB-PA007333 | Phospho-CSF1R (Y809) Antibody | Human | IHC, ELISA |
| CSB-PA007334 | CSF1R Antibody | Human,Mouse,Rat | WB, IHC, IF, ELISA |
| CSB-PA007335 | CSF1R Antibody | Human | WB, ELISA |
| CSB-PA007337 | CSF1R Antibody | Human,Mouse,Rat | WB, IHC, ELISA |
| CSB-PA300271 | CSF1R Antibody | Human,Mouse,Rat | ELISA,IHC |
| CSB-PA678661 | CSF1R Antibody | Human,Mouse,Rat | ELISA,WB |
CSF1R Proteins
CSF1R Proteins for Felis catus (Cat) (Felis silvestris catus)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP006044CA CSB-BP006044CA CSB-MP006044CA CSB-EP006044CA-B |
Recombinant Cat Macrophage colony-stimulating factor 1 receptor (CSF1R), partial | Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-EP006044CA | Recombinant Cat Macrophage colony-stimulating factor 1 receptor (CSF1R), partial | E.coli |
CSF1R Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP006044HU CSB-EP006044HU CSB-BP006044HU CSB-EP006044HU-B |
Recombinant Human Macrophage colony-stimulating factor 1 receptor (CSF1R), partial | Yeast E.coli Baculovirus In Vivo Biotinylation in E.coli |
| CSB-MP006044HU | Recombinant Human Macrophage colony-stimulating factor 1 receptor (CSF1R), partial | Mammalian cell |
| CSB-MP006044HUi10 | Recombinant Human Macrophage colony-stimulating factor 1 receptor (CSF1R), partial | Mammalian cell |
CSF1R Proteins for Mus musculus (Mouse)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP006044MO CSB-EP006044MO CSB-BP006044MO CSB-EP006044MO-B |
Recombinant Mouse Macrophage colony-stimulating factor 1 receptor (Csf1r), partial | Yeast E.coli Baculovirus In Vivo Biotinylation in E.coli |
CSF1R Proteins for Danio rerio (Zebrafish) (Brachydanio rerio)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP888246DIL CSB-EP888246DIL CSB-BP888246DIL CSB-MP888246DIL CSB-EP888246DIL-B |
Recombinant Danio rerio Macrophage colony-stimulating factor 1 receptor (csf1r), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CSF1R ELISA Kit
CSF1R ELISA Kit for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-E10012h | Human Macrophage Colony-Stimulating Factor Receptor,M-CSFR ELISA Kit | serum, plasma, tissue homogenates | 0.039 ng/mL |
CSF1R ELISA Kit for Rattus norvegicus (Rat)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-EL006044RA | Rat Macrophage colony-stimulating factor 1 receptor(CSF1R) ELISA kit | serum, plasma, tissue homogenates | 0.078 ng/mL |
