腎癌

腎癌，也稱為腎細胞癌，是一種起源于腎小管上皮細胞的惡性腫瘤，可發(fā)生在腎臟的任何部位。腎癌的臨床表現(xiàn)多變，容易誤診為其他疾病。常見的癥狀包括血尿、腰痛、腫塊以及全身表現(xiàn)如發(fā)熱、高血壓等。

腎癌傳統(tǒng)的治療方式包括手術切除、放射療法和免疫療法。近年來，靶向治療和免疫療法的發(fā)展為腎癌患者提供了新的治療選擇。靶向治療藥物專門針對癌細胞中的特定異常，通過阻斷這些異常來殺死癌細胞。例如，VEGFR酪氨酸激酶抑制劑類藥物是治療腎癌的常見靶向藥物。免疫療法則利用患者自身的免疫系統(tǒng)來對抗癌癥，通過干預癌細胞躲避免疫系統(tǒng)的機制來發(fā)揮作用。PD-1抑制劑和CTLA-4抑制劑是兩種常用的免疫檢查點抑制劑，它們通過激活T細胞來攻擊癌細胞。

腎癌藥物靶點

腎癌藥物靶點相關產品推薦

● 靶點蛋白

PDCD1
CSB-MP619964HU1

Measured by its binding ability in a functional ELISA. Immobilized PD-1 at 2 μg/ml can bind Anti-PD-1 recombinant antibody, the EC₅₀ of human PD-1 protein is 6.087-7.854 ng/ml.

CTLA4
CSB-MP006163HU1

Measured by its binding ability in a functional ELISA. Immobilized CD152 at 2 μg/ml can bind Anti-CD152 rabbit monoclonal antibody (CSB-RA213310A0HU), the EC₅₀ of human CD152 protein is 27.14-34.82 ng/ml.

IL2RA
CSB-MP011649HU3

Measured by its binding ability in a functional ELISA. Immobilized Human IL2RA at 2μg/mL can bind Anti-IL2RA recombinant antibody (CSB-RA011649MA1HU)，the EC₅₀ is 2.463-3.353 ng/mL.

CD274
CSB-MP878942HU1

Measured by its binding ability in a functional ELISA. Immobilized PD-L1 at 2 μg/ml can bind Anti- PD-L1 mouse monoclonal antibody(CSB-MA878942A1m, antigen from E.coli), the EC₅₀ of human PD-L1 protein is 1.252-1.653 ng/mL

CD70
CSB-MP004954HU1

Measured by its binding ability in a functional ELISA. Immobilized Human CD70 at 2 μg/ml can bind Anti-CD70 antibody, the EC₅₀ is 2.414-3.196 ng/mL.

EGFR
CSB-MP007479HU

Human EGF protein captured on COOH chip can bind Human EGFR protein, his and Myc tag (CSB-MP007479HU) with an affinity constant of 11.9nM as detected by LSPR Assay.

ERBB2
CSB-MP007763HU

Measured by its binding ability in a functional ELISA. Immobilized HER2 at 2 μg/ml can bind Trastuzumab, the EC₅₀ is 2.179-2.825 ng/ml.

CD276
CSB-MP733578HU

Measured by its binding ability in a functional ELISA. Immobilized CD276 at 2 μg/ml can bind Anti-CD276 rabbit monoclonal antibody, the EC₅₀ of human CD276 protein is 1.961-2.243 ng/ml.

產品名稱	貨號	靶點	來源	蛋白標簽
Recombinant Human Interleukin-2 receptor subunit alpha (IL2RA), partial (Active)	CSB-MP011649HU3	IL2RA	Mammalian cell	C-terminal 10xHis-tagged
Recombinant Human Interleukin-2 (IL2) (Active)	CSB-MP011629HU	IL2	Mammalian cell	N-terminal hFc-tagged
Recombinant Mouse Interleukin-2 (Il2) (Active)	CSB-AP004821MO	Il2	E.coli	Tag-Free
Recombinant Human Interleukin-2 (IL2), partial (Active)	CSB-AP004711HU	IL2	Mammalian cell	C-terminal 6xHis-tagged
Recombinant Human Interleukin-2 (IL2) (Active)	CSB-AP004501HU	IL2	Mammalian cell	C-terminal 6xHis-tagged
Recombinant Human Interleukin-2 (IL2) (Active)	CSB-AP004381HU	IL2	E.coli	Tag-Free
Recombinant Human Interleukin-2 protein (IL2) (Active)	CSB-AP001691HU	IL2	E.Coli	Tag-Free
Recombinant Mouse Interleukin-15 receptor subunit alpha (Il15ra), partial (Active)	CSB-AP004801MO	Il15ra	Mammalian cell	C-terminal Fc-tagged
Recombinant Human Interleukin-15 receptor subunit alpha (IL15RA), partial (Active)	CSB-AP004551HU	IL15RA	Mammalian cell	C-terminal Fc-tagged
Recombinant Human Receptor tyrosine-protein kinase erbB-2 (ERBB2), partial (Active)	CSB-MP007763HU	ERBB2	Mammalian cell	C-terminal 6xHis-tagged
Recombinant Macaca fascicularis Ectonucleotide pyrophosphatase/phosphodiesterase 3 (ENPP3), partial (Active)	CSB-MP4278MOV	ENPP3	Mammalian cell	N-terminal 10xHis-tagged
Recombinant Human Ectonucleotide pyrophosphatase/phosphodiesterase family member 3 (ENPP3), partial (Active)	CSB-MP007681HU	ENPP3	Mammalian cell	C-terminal 10xHis-tagged
Recombinant Human Epidermal growth factor receptor (EGFR), partial (Active)	CSB-MP007479HU	EGFR	Mammalian cell	N-terminal 10xHis-tagged and C-terminal Myc-tagged
Recombinant Human Cytotoxic T-lymphocyte protein 4 (CTLA4), partial (Active)	CSB-MP006163HU1	CTLA4	Mammalian cell	C-terminal hFc-tagged
Recombinant Mouse Cytotoxic T-lymphocyte protein 4 (Ctla4), partial (Active)	CSB-AP005301MO	Ctla4	Mammalian cell	C-terminal 6xHis-tagged
Recombinant Human Cytotoxic T-lymphocyte protein 4 (CTLA4), partial (Active)	CSB-AP005231HU	CTLA4	Mammalian cell	C-terminal 6xHis-tagged
Recombinant Guinea pig Cytotoxic T-lymphocyte associated protein 4 (CTLA4), partial (Active)	CSB-AP005121GU	CTLA4	Yeast	C-terminal 6xHis-tagged
Recombinant Human CD70 antigen (CD70), partial (Active)	CSB-MP004954HU1	CD70	Mammalian cell	N-terminal 10xHis-tagged
Recombinant Human Tumor necrosis factor receptor superfamily member 5 (CD40), partial (Active)	CSB-MP004936HU1	CD40	Mammalian cell	C-terminal hFc-tagged
Recombinant Human Tumor necrosis factor receptor superfamily member 5 (CD40), partial (Active)	CSB-AP005181HU	CD40	Mammalian cell	C-terminal Fc-tagged

● 穩(wěn)定細胞株

HEK293T/Human ENPP3 Stable Cell Line

CSB-SC007681HU

Untransfected HEK293T cells (green line) and transfected Human ENPP3 HEK293T Stable cells (red line) were stained with anti-ENPP3 antibody (2μg/1*10⁶ cells), washed and then followed by FITC-conjugated anti-Human IgG Fc antibody and analyzed with flow cytometry.

● 重組抗體

BTLA Recombinant Monoclonal Antibody
CSB-RA773799MA1HU

Untransfected HEK293T cells (green line) and transfected Human ENPP3 HEK293T Stable cells (red line) were stained with anti-ENPP3 antibody (2μg/1*10⁶ cells).

CD247 Recombinant Monoclonal Antibody
CSB-RA244537A0HU

Overlay Peak curve showing Jurkat cells surface stained with CSB-RA244537A0HU (red line) at 1:50.

CD274 Recombinant Monoclonal Antibody
CSB-RA878942MA1HU

Overlay Peak curve showing Hela cells surface stained with CSB-RA878942MA1HU (red line) at 1:100.

CD40 Recombinant Monoclonal Antibody
CSB-RA004936MA1HU

Overlay Peak curve showing THP-1 cells surface stained with CSB-RA004936MA1HU (red line) at 1:100.

產品名稱	貨號	靶點	反應種屬	應用范圍
ANGPT2 Recombinant Monoclonal Antibody	CSB-RA191985A0HU	ANGPT2	Human	ELISA, IHC
ANGPT2 Recombinant Monoclonal Antibody	CSB-RA001707MA01HU	ANGPT2	Human	ELISA
BTLA Recombinant Monoclonal Antibody	CSB-RA773799MA1HU	BTLA	Human	ELISA, FC
CA9 Recombinant Monoclonal Antibody	CSB-RA614990A0HU	CA9	Human	ELISA, IHC
CD247 Recombinant Monoclonal Antibody	CSB-RA244537A0HU	CD247	Human	ELISA, FC
CD27 Recombinant Monoclonal Antibody	CSB-RA953976A0HU	CD27	Human	ELISA, WB
CD274 Recombinant Monoclonal Antibody	CSB-RA977797A0HU	CD274	Human	ELISA, WB, IHC
CD274 Recombinant Monoclonal Antibody	CSB-RA878942MA1HU	CD274	Human	ELISA, IHC, FC
CD40 Recombinant Monoclonal Antibody	CSB-RA004936MA1HU	CD40	Human	ELISA, IF, FC
CD70 Recombinant Monoclonal Antibody	CSB-RA004954MA1HU	CD70	Human	ELISA
CDH6 Recombinant Monoclonal Antibody	CSB-RA005055MA1HU	CDH6	Human	ELISA
CTLA4 Recombinant Monoclonal Antibody	CSB-RA213310A0HU	CTLA4	Human	ELISA, IHC
CTLA4 Recombinant Monoclonal Antibody	CSB-RA006163MA1HU	CTLA4	Human, Mouse	ELISA, WB, IF, FC
Phospho-EGFR (Y1092) Recombinant Monoclonal Antibody	CSB-RA007479A1092phHU	EGFR	Human	ELISA, WB
Phospho-EGFR (Y1068) Recombinant Monoclonal Antibody	CSB-RA007479A1068phHU	EGFR	Human	ELISA, WB
EGFR Recombinant Monoclonal Antibody	CSB-RA159341A0HU	EGFR	Human	ELISA, WB, IHC, IF, FC
EGFR Recombinant Monoclonal Antibody	CSB-RA794061A0HU	EGFR	Human	ELISA, WB, IHC
EGFR Recombinant Monoclonal Antibody	CSB-RA159341MA1HU	EGFR	Human	ELISA, IHC, FC
ENPP3 Recombinant Monoclonal Antibody	CSB-RA007681MA1HU	ENPP3	Human, Macaca fascicularis	ELISA,FC
ERBB2 Recombinant Monoclonal Antibody	CSB-RA260392A0HU	ERBB2	Human	ELISA, IHC, IF
ERBB2 Recombinant Monoclonal Antibody	CSB-RA007763MA1HU	ERBB2	Human	ELISA
Phospho-ERBB2 (Y1139) Recombinant Monoclonal Antibody	CSB-RA588766A0HU	ERBB2	Human	ELISA, IHC, IF
ERBB2 Recombinant Monoclonal Antibody	CSB-RA007763MA2HU	ERBB2	Human	ELISA, IHC
IFNAR1 Recombinant Monoclonal Antibody	CSB-RA011046A0HU	IFNAR1	Human	ELISA
IL2RA Recombinant Monoclonal Antibody	CSB-RA011649MA1HU	IL2RA	Human	ELISA, IF
NT5E Recombinant Monoclonal Antibody	CSB-RA978310A0HU	NT5E	Human	ELISA, IHC
PDCD1 Recombinant Monoclonal Antibody	CSB-RA240597A0HU	PDCD1	Human	ELISA, WB, IHC
TOP1 Recombinant Monoclonal Antibody	CSB-RA792129A0HU	TOP1	Human	ELISA, WB, IHC, FC, IP
TPBG Recombinant Monoclonal Antibody	CSB-RA669019A0HU	TPBG	Human	ELISA, IHC
TPBG Recombinant Monoclonal Antibody	CSB-RA902876A0HU	TPBG	Human, Mouse	ELISA, WB, IHC
TPBG Recombinant Monoclonal Antibody	CSB-RA024093MA1HU	TPBG	Human, Macaca mulatta	ELISA

● ELISA試劑盒

產品名稱	貨號	靶點	檢測范圍	靈敏度
Human Angiopoietin 2,ANG-2 ELISA Kit	CSB-E04500h	ANGPT2	39 pg/mL-2500 pg/mL	9.75 pg/mL
Rat Angiopoietin 2,ANG-2 ELISA Kit	CSB-E07304r	ANGPT2	Request Information	Request Information
Mouse Angiopoietin 2,ANG-2 ELISA Kit	CSB-E07305m	ANGPT2	0.156 pg/mL-10 pg/mL	0.039 pg/mL
Pig Angiopoietin 2,ANG-2 ELISA Kit	CSB-E08460p	ANGPT2	0.94 ng/mL-60 ng/mL	0.235 ng/mL
Human B- and T-lymphocyte attenuator(BTLA) ELISA kit	CSB-EL002868HU	BTLA	0.45 ng/mL-30 ng/mL	0.11 ng/mL
Mouse B- and T-lymphocyte attenuator(BTLA) ELISA kit	CSB-EL002868MO	BTLA	0.625 ng/mL-40 ng/mL	0.156 ng/mL
Human Carbonic Anhydrase 9(CA9) ELISA Kit	CSB-E13266h	CA9	31.25 pg/mL-2000 pg/mL	7.81 pg/mL
Human T-cell surface glycoprotein CD3 zeta chain (CD247) ELISA kit	CSB-EL004904HU	CD247	0.156 ng/mL-10 ng/mL	0.039 ng/mL
Human Programmed Death Ligand-1(PD-L1/CD274) ELISA Kit	CSB-E13644h	CD274	15.6 pg/mL-1000 pg/mL	3.9 pg/mL
Mouse Programmed cell death 1 ligand 1(CD274) ELISA kit	CSB-EL004911MO	CD274	31.25 pg/mL-2000 pg/mL	7.81 pg/mL
Human Soluble CD276,sCD276/sB7-H3 ELISA Kit	CSB-E14285h	CD276	3.12 ng/mL-200 ng/mL	0.78 ng/mL
Human soluble cluster of differentiation 28,sCD28 ELISA Kit	CSB-E09296h	CD28	0.625 ng/mL-40 ng/mL	0.156 ng/mL
Mouse Tumor necrosis factor receptor superfamily member 5(CD40) ELISA kit	CSB-EL004936MO	CD40	Request Information	Request Information
Human CD70 antigen(CD70) ELISA kit	CSB-EL004954HU	CD70	0.156 ng/mL-10 ng/mL	0.039 ng/mL
Mouse CD70 antigen(CD70) ELISA kit	CSB-EL004954MO	CD70	Request Information	Request Information
Human cytotoxic T lymphocyte associated antigen 4,CTLA-4 ELISA Kit	CSB-E09171h	CTLA4	125 pg/mL-8000 pg/mL	31.25 pg/mL
Mouse cytotoxic T lymphocyte associated antigen 4,CTLA-4 ELISA Kit	CSB-E13637m	CTLA4	0.312 ng/mL-20 ng/mL	0.078 ng/mL
Human epidermal growth factor receptor,EGFR ELISA Kit	CSB-E12124h	EGFR	0.312 ng/mL-20 ng/mL	0.019 ng/mL
Human Ectonucleotide pyrophosphatase/phosphodiesterase family member 3(ENPP3) ELISA kit	CSB-EL007681HU	ENPP3	0.156 ng/mL-10 ng/mL	0.039 ng/mL
Human epidermal growth factor receptor 2 (sp185/HER2) ELISA Kit	CSB-E11161h	ERBB2	0.156 ng/mL-10 ng/mL	0.04 ng/mL