肝癌
肝癌是一種發(fā)生在肝臟的惡性腫瘤，主要包括肝細胞癌（Hepatocellular carcinoma, HCC）、肝內膽管癌（Intrahepatic cholangiocarcinoma, ICC）和混合型肝細胞癌-膽管癌（Combined hepatocellular-cholangiocarcinoma, cHCC-CCA）等類型。
肝癌的發(fā)病原因多樣，常見的風險因素包括乙型肝炎病毒（HBV）和丙型肝炎病毒（HCV）感染、過度飲酒、非酒精性脂肪性肝炎、肝硬化以及其他原因引起的慢性肝病。肝癌的早期癥狀較為隱匿，但隨著病情進展，可能出現腹痛、腹部腫脹、黃疸、體重下降等癥狀。
肝癌常用的治療手段包括手術切除、肝移植、局部消融治療、經動脈化療栓塞（Transarterial chemoembolization, TACE）、放射治療、系統(tǒng)抗腫瘤治療等。近年來，隨著對肝癌生物學認識的深入和治療技術的進步，肝癌的藥物研發(fā)也取得了顯著進展，如：
- 分子靶向治療：多納非尼（Sorafenib）、侖伐替尼（Lenvatinib）等多激酶抑制劑在肝癌治療中顯示出較好的療效，能夠抑制腫瘤生長和血管生成。
- 免疫治療：免疫檢查點抑制劑如納武利尤單抗（Nivolumab）和帕博利珠單抗（Pembrolizumab）等已在肝癌治療中顯示出潛力，通過激活患者自身的免疫系統(tǒng)來攻擊腫瘤細胞。
- 聯(lián)合治療：將免疫治療藥物與血管生成抑制劑或其他藥物聯(lián)合使用，如阿特珠單抗（Atezolizumab）與貝伐珠單抗（Bevacizumab）的聯(lián)合治療，已被證實能顯著延長患者的生存期。
肝癌藥物靶點
肝癌藥物靶點相關產品推薦
● 靶點蛋白
CSB-MP619964HU1
Measured by its binding ability in a functional ELISA. Immobilized PD-1 at 2 μg/ml can bind Anti-PD-1 recombinant antibody, the EC50 of human PD-1 protein is 6.087-7.854 ng/ml.
CSB-MP009705HU(M)
Measured by its binding ability in a functional ELISA. Immobilized CD152 at 2 μg/ml can bind Anti-CD152 rabbit monoclonal antibody (CSB-RA213310A0HU), the EC50 of human CD152 protein is 27.14-34.82 ng/ml.
CSB-MP004900HU
Measured by its binding ability in a functional ELISA. Immobilized human GPC3 (G537R) at 5 μg/ml can bind Anti-GPC3 recombinant antibody, the EC50 is 4.739-7.092 ng/ml.
CSB-MP878942HU1
-AC1.jpg)
Measured by its binding ability in a functional ELISA. Immobilized PD-L1 at 2 μg/ml can bind Anti- PD-L1 mouse monoclonal antibody (CSB-MA878942A1m, antigen from E.coli), the EC50 of human PD-L1 protein is 1.252-1.653 ng/mL
CSB-MP007479HU
Human EGF protein captured on COOH chip can bind Human EGFR protein, his and Myc tag (CSB-MP007479HU) with an affinity constant of 11.9nM as detected by LSPR Assay.
CSB-MP675446HU
HFACS assay shows that Human TIGIT can bind to 293F cell overexpressing human CD155.
Measured by its binding ability in a functional ELISA. Immobilized MET at 2 μg/ml can bind Anti-MET recombinant antibody, the EC50 is 2.379-3.094 ng/ml.
CSB-MP007765HU
Measured by its binding ability in a functional ELISA. Immobilized NRG1 (CSB-MP016077HU1(F6)) at 2 μg/ml can bind human ERBB3, the EC50 is 12.32-15.74 ng/ml.
● 穩(wěn)定細胞株
CT26/Human GPC3 Stable Cell Line
CSB-SC009705HU2
Untransfected CT26 cells (green line) and transfected Human GPC3 CT26 Stable cells (red line) were stained with anti-GPC3 antibody(CSB-RA009705A1HU) (2μg/1*106 cells), washed and then followed by APC-conjugated anti-Human IgG Fc antibody and analyzed with flow cytometry.
● 重組抗體
CSB-RA878942MA1HU
Overlay Peak curve showing Hela cells surface stained with CSB-RA878942MA1HU (red line) at 1:100.
CSB-RA006163MA1HU
Overlay Peak curve showing JK cells surface stained with CSB-RA006163MA1HU (red line) at 1:50.
CSB-RA792129A0HU
Overlay histogram showing HepG2 cells stained with CSB-RA792129A0HU (red line) at 1:50.
CSB-RA024077MA1HU
Overlay Peak curve showing Hela cells surface stained with CSB-RA024077MA1HU (red line) at 1:100.
| 產品名稱 | 貨號 | 靶點 | 反應種屬 | 應用范圍 |
|---|---|---|---|---|
| ACVRL1 Recombinant Monoclonal Antibody | CSB-RA555022A0HU | ACVRL1 | Human | ELISA, WB, IHC |
| ACVRL1 Recombinant Monoclonal Antibody | CSB-RA001262MA1HU | ACVRL1 | Human | ELISA |
| CD247 Recombinant Monoclonal Antibody | CSB-RA244537A0HU | CD247 | Human | ELISA, FC |
| CD274 Recombinant Monoclonal Antibody | CSB-RA977797A0HU | CD274 | Human | ELISA, WB, IHC |
| CD274 Recombinant Monoclonal Antibody | CSB-RA878942MA1HU | CD274 | Human | ELISA, IHC, FC |
| CD40 Recombinant Monoclonal Antibody | CSB-RA004936MA1HU | CD40 | Human | ELISA, IF, FC |
| CEACAM5 Recombinant Monoclonal Antibody | CSB-RA005165MA3HU | CEACAM5 | Human | ELISA, IF, FC |
| CEACAM5 Recombinant Monoclonal Antibody | CSB-RA005165MA1HU | CEACAM5 | Human | ELISA |
| CTLA4 Recombinant Monoclonal Antibody | CSB-RA213310A0HU | CTLA4 | Human | ELISA, IHC |
| CTLA4 Recombinant Monoclonal Antibody | CSB-RA006163MA1HU | CTLA4 | Human, Mouse | ELISA, WB, IF, FC |
| Phospho-EGFR (Y1092) Recombinant Monoclonal Antibody | CSB-RA007479A1092phHU | EGFR | Human | ELISA, WB |
| Phospho-EGFR (Y1068) Recombinant Monoclonal Antibody | CSB-RA007479A1068phHU | EGFR | Human | ELISA, WB |
| EGFR Recombinant Monoclonal Antibody | CSB-RA159341A0HU | EGFR | Human | ELISA, WB, IHC, IF, FC |
| EGFR Recombinant Monoclonal Antibody | CSB-RA794061A0HU | EGFR | Human | ELISA, WB, IHC |
| EGFR Recombinant Monoclonal Antibody | CSB-RA159341MA1HU | EGFR | Human | ELISA, IHC, FC |
| EPCAM Recombinant Monoclonal Antibody | CSB-RA932207A0HU | EPCAM | Human | ELISA, WB |
| EPCAM Recombinant Monoclonal Antibody | CSB-RA439934A0HU | EPCAM | Human | ELISA, WB, IHC |
| EPCAM Recombinant Monoclonal Antibody | CSB-RA007717MA1HU | EPCAM | Human | ELISA, IHC, FC |
| ERBB2 Recombinant Monoclonal Antibody | CSB-RA260392A0HU | ERBB2 | Human | ELISA, IHC, IF |
| ERBB2 Recombinant Monoclonal Antibody | CSB-RA007763MA1HU | ERBB2 | Human | ELISA |
● ELISA試劑盒
| 產品名稱 | 貨號 | 靶點 | 檢測范圍 | 靈敏度 |
|---|---|---|---|---|
| Human Alpha-fetoprotein,AFP ELISA Kit | CSB-E04770h | AFP | 1.563 ng/mL-100 ng/mL | 1.332 ng/mL |
| Mouse Alpha-fetoprotein,AFP ELISA Kit | CSB-E08282m | AFP | 1.23 ng/ml-900 ng/ml. | 1.23 ng/ml. |
| Rat Alpha-fetoprotein,AFP ELISA Kit | CSB-E08281r | AFP | 15.6 pg/mL-1000 pg/mL | 3.9 pg/mL |
| Pig Alpha-fetoprotein(AFP) ELISA kit | CSB-EL001421PI | AFP | 3.12 ng/mL-200 ng/mL | 0.78 ng/mL |
| Human T-cell surface glycoprotein CD3 zeta chain (CD247) ELISA kit | CSB-EL004904HU | CD247 | 0.156 ng/mL-10 ng/mL | 0.039 ng/mL |
| Human Programmed Death Ligand-1(PD-L1/CD274) ELISA Kit | CSB-E13644h | CD274 | 15.6 pg/mL-1000 pg/mL | 3.9 pg/mL |
| Mouse Programmed cell death 1 ligand 1(CD274) ELISA kit | CSB-EL004911MO | CD274 | 31.25 pg/mL-2000 pg/mL | 7.81 pg/mL |
| Mouse Tumor necrosis factor receptor superfamily member 5(CD40) ELISA kit | CSB-EL004936MO | CD40 | Request Information | Request Information |
| Human carcinoembryonic antigen,CEA ELISA Kit | CSB-E04767h | CEACAM5 | 5 ng/mL-120 ng/mL | 2 ng/mL |
| Mouse carcinoembryonic antign,CEA ELISA Kit | CSB-E13925m | CEACAM5 | 62.5 pg/mL-4000 pg/mL | 15.6 pg/mL |
| Human cytotoxic T lymphocyte associated antigen 4,CTLA-4 ELISA Kit | CSB-E09171h | CTLA4 | 125 pg/mL-8000 pg/mL | 31.25 pg/mL |
| Mouse cytotoxic T lymphocyte associated antigen 4,CTLA-4 ELISA Kit | CSB-E13637m | CTLA4 | 0.312 ng/mL-20 ng/mL | 0.078 ng/mL |
| Mouse Protein delta homolog 1(DLK1) ELISA kit | CSB-EL006945MO | DLK1 | 15.6 pg/mL-1000 pg/mL | 3.9 pg/mL |
| Human epidermal growth factor receptor,EGFR ELISA Kit | CSB-E12124h | EGFR | 0.312 ng/mL-20 ng/mL | 0.019 ng/mL |
| Human Epithelial cell adhesion molecule(EPCAM) ELISA kit | CSB-EL007717HU | EPCAM | 0.625 ng/ml-40 ng/ml | 0.156 ng/ml |
| Human epidermal growth factor receptor 2 (sp185/HER2) ELISA Kit | CSB-E11161h | ERBB2 | 0.156 ng/mL-10 ng/mL | 0.04 ng/mL |
| Human Receptor tyrosine-protein kinase erbB-3(ERBB3) ELISA kit | CSB-EL007765HU | ERBB3 | 125 pg/mL-8000 pg/mL | 31.25 pg/mL |
| Human Fibroblast growth factor receptor 3(FGFR3) ELISA kit | CSB-EL008646HU | FGFR3 | 62.5 pg/mL-4000 pg/mL | 15.6 pg/mL |
| Human Glypican-3,GPC-3 ELISA Kit | CSB-E11333h | GPC3 | 0.625 ng/mL-40 ng/mL | 0.156 ng/mL |
| Mouse Glypican-3(GPC-3)ELISA Kit | CSB-E15877m | GPC3 | 3.12 ng/mL-200 ng/mL | 0.78 ng/mL |
