SEZ6
SEZ6，即癲癇相關(guān)同源物6，別名SC-011。它是由位于17q11.2染色體的SEZ6基因編碼的蛋白質(zhì)，屬于SEZ6家族中的一員。SEZ6家族包括SEZ6、SEZ6L和SEZ6L2，這些成員在神經(jīng)系統(tǒng)的發(fā)育和功能中起著關(guān)鍵作用。SEZ6的作用機制與其在細胞表面的存在有關(guān)，它參與神經(jīng)樹突的形成和神經(jīng)信號的傳遞。SEZ6的結(jié)構(gòu)域由5個Sushi結(jié)構(gòu)域和2-3個CUB結(jié)構(gòu)域組成，這些結(jié)構(gòu)域參與蛋白質(zhì)-蛋白質(zhì)相互作用，并可能參與細胞間粘附或離子型神經(jīng)遞質(zhì)受體的調(diào)節(jié)。此外，SEZ6還可能與補體級聯(lián)相關(guān)，通過促進C3b的因子I裂解和加速C3轉(zhuǎn)化酶的衰變來抑制補體。SEZ6的高表達與腫瘤的發(fā)展和轉(zhuǎn)移有關(guān)，尤其是在神經(jīng)內(nèi)分泌腫瘤中。SEZ6已成為腫瘤治療的潛在靶點，為開發(fā)新的癌癥治療策略提供了重要信息。
熱銷產(chǎn)品
Recombinant Human Seizure protein 6 homolog (SEZ6), partial (Active) (CSB-MP684467HU2)
驗證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Activity
Measured by its binding ability in a functional ELISA. Immobilized Human SEZ6 at 2 μg/ml can bind Anti-SEZ6 recombinant antibody (CSB-RA684467MA1HU). The EC50 is 2.324-2.770 ng/mL.
Recombinant Macaca fascicularis Seizure related 6 homolog (SEZ6), partial (Active) (CSB-MP6419MOV)
驗證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Activity
Measured by its binding ability in a functional ELISA. Immobilized Macaca fascicularis SEZ6 at 2 μg/ml can bind Anti-SEZ6 recombinant antibody (CSB-RA684467MA1HU). The EC50 is 0.6865-1.065 ng/mL.
SEZ6 Recombinant Monoclonal Antibody (CSB-RA684467MA1HU)
驗證數(shù)據(jù)
The Binding Activity of Cynomolgus SEZ6 with Anti-SEZ6 recombinant antibody
Activity: Measured by its binding ability in a functional ELISA. Immobilized Cynomolgus SEZ6 (CSB-MP6419MOV) at 2 μg/mL can bind Anti-SEZ6 recombinant antibody. The EC50 is 0.6865-1.065 ng/mL.
The Binding Activity of Human SEZ6 with Anti-SEZ6 Recombinant Antibody
Activity: Measured by its binding ability in a functional ELISA. Immobilized Human SEZ6 (CSB-MP684467HU2) at 2 μg/mL can bind Anti-SEZ6 recombinant antibody. The EC50 is 2.324-2.770 ng/mL.
SEZ6 Antibodies
SEZ6 for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA684467HA01HU | SEZ6 Antibody | Human | ELISA, IF |
| CSB-PA684467HD01HU | SEZ6 Antibody, Biotin conjugated | Human | ELISA |
| CSB-PA684467HC01HU | SEZ6 Antibody, FITC conjugated | Human |
SEZ6 Proteins
SEZ6 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP684467HU CSB-EP684467HU CSB-BP684467HU CSB-MP684467HU CSB-EP684467HU-B |
Recombinant Human Seizure protein 6 homolog (SEZ6), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
