皮膚和結(jié)締組織疾病

皮膚和結(jié)締組織疾病是一類影響皮膚、肌肉、骨骼、血管和其他連接組織的疾病。這些疾病可能是由于遺傳、免疫異常、環(huán)境因素或其他未知因素引起的。一些常見的皮膚和結(jié)締組織疾病包括系統(tǒng)性紅斑狼瘡(SLE)、類風濕關(guān)節(jié)炎(RA)、皮肌炎、干燥綜合征(SS)、系統(tǒng)性硬化癥等。

近年來，皮膚和結(jié)締組織疾病的藥物研發(fā)正在不斷取得進展，部分列舉如下：

Janus激酶（JAK）抑制劑：JAK抑制劑是治療皮膚病如銀屑病和特應(yīng)性皮炎的新型藥物，通過調(diào)節(jié)細胞信號傳導(dǎo)發(fā)揮作用。
芳香烴受體(AhR)調(diào)節(jié)劑：AhR是一種轉(zhuǎn)錄調(diào)控因子，參與多種生理過程，包括免疫調(diào)節(jié)。AhR調(diào)節(jié)劑治療炎癥性皮膚病具有獨特作用機制，正在成為皮膚病治療格局的改變者。
siRNA經(jīng)皮給藥系統(tǒng)：（小干擾RNA）經(jīng)皮給藥系統(tǒng)成為皮膚疾病治療研究的熱點，尤其是針對細胞毒性T淋巴細胞相關(guān)抗原-4（CTLA-4）和程序性細胞死亡-1（PD-1）的siRNA抑制劑可用于皮膚黑素瘤的治療。

皮膚和結(jié)締組織疾病藥物靶點

皮膚和結(jié)締組織疾病靶點相關(guān)產(chǎn)品推薦

● 靶點蛋白

ERBB2
CSB-MP007763HU

Measured by its binding ability in a functional ELISA. Immobilized HER2 at 2 μg/ml can bind Trastuzumab, the EC₅₀ is 2.179-2.825 ng/ml.

PDCD1
CSB-MP619964HU1

Measured by its binding ability in a functional ELISA. Immobilized PD-1 at 2 μg/ml can bind Anti-PD-1 recombinant antibody, the EC₅₀ of human PD-1 protein is 6.087-7.854 ng/ml.

MS4A1 (CD20)
CSB-MP015007HU

Measured by its binding ability in a functional ELISA. Immobilized human CD20 at 2 μg/ml can bind Anti-CD20 recombinant antibody (CSB-RA015007A1HU), the EC₅₀ is 3.243-7.085 ng/mL

GLP1R
CSB-BP624104HU(M)

Measured by its binding ability in a functional ELISA. Immobilized Human IL17A at 2 μg/ml can bind Anti-IL17A recombinant antibody (CSB-RA624104MA1HU), the EC₅₀ is 1.818-2.170 ng/mL.

CD274
CSB-MP878942HU1

Measured by its binding ability in a functional ELISA. Immobilized PD-L1 at 2 μg/ml can bind Anti- PD-L1 mouse monoclonal antibody (CSB-MA878942A1m, antigen from E.coli), the EC₅₀ of human PD-L1 protein is 1.252-1.653 ng/mL

EGFR
CSB-MP007479HU

Human EGF protein captured on COOH chip can bind Human EGFR protein, his and Myc tag (CSB-MP007479HU) with an affinity constant of 11.9nM as detected by LSPR Assay.

IL4R
CSB-MP011661HU2-B

Measured by its binding ability in a functional ELISA. Immobilized Human IL4 (CSB-MP011659HU) at 2μg/mL can bind biotinylated Human IL4R，the EC₅₀ is 12.68-14.23 ng/mL.

TACSTD2(TROP2)
CSB-MP023072HU1

Measured in cell activity assay using U937 cells, the EC₅₀ for this effect is 190.2-298.6 ng/ml.

產(chǎn)品名稱	貨號	靶點	來源	蛋白標簽
Recombinant Human B- and T-lymphocyte attenuator (BTLA), partial (Active)	CSB-MP773799HU	BTLA	Mammalian cell	C-terminal hFc-Myc-tagged
Recombinant Human B- and T-lymphocyte attenuator (BTLA), partial (Active)	CSB-MP773799HU1	BTLA	Mammalian cell	C-terminal 10xHis-tagged
Recombinant Human B-lymphocyte antigen CD19 (CD19), partial (Active)	CSB-AP005061HU	CD19	Mammalian cell	C-terminal Fc-tagged
Recombinant Human Programmed cell death 1 ligand 1 (CD274), partial (Active)	CSB-MP878942HU1	CD274	Mammalian cell	C-terminal hFc-tagged
Recombinant Human CD276 antigen (CD276), partial (Active)	CSB-MP733578HU	CD276	Mammalian cell	C-terminal hFc-Myc-tagged
Recombinant Human Tumor necrosis factor receptor superfamily member 5 (CD40), partial (Active)	CSB-AP005181HU	CD40	Mammalian cell	C-terminal Fc-tagged
Recombinant Human Tumor necrosis factor receptor superfamily member 5 (CD40), partial (Active)	CSB-MP004936HU1	CD40	Mammalian cell	C-terminal hFc-tagged
Recombinant Human CD40 ligand (CD40LG), partial (Active)	CSB-AP005191HU	CD40LG	E.coli	Tag-Free
Recombinant Human CD40 ligand (CD40LG), partial (Active)	CSB-MP004937HU3	CD40LG	Mammalian cell	N-terminal hFc-Flag-tagged
Recombinant Human CD44 antigen (CD44), partial (Active)	CSB-MP004938HU(F1)	CD44	Mammalian cell	C-terminal hFc-tagged
Recombinant Human CD44 antigen (CD44), partial, Biotinylated (Active)	CSB-MP004938HU(F1)j1-B	CD44	Mammalian cell	C-terminal mFc-Avi-tagged
Recombinant Macaca fascicularis CD44 antigen (CD44), partial (Active)	CSB-MP4290MOV	CD44	Mammalian cell	C-terminal 10xHis-tagged
Recombinant Human Leukocyte surface antigen CD47 (CD47), partial (Active)	CSB-AP005201HU	CD47	Mammalian cell	C-terminal 6xHis-tagged
Recombinant Human Leukocyte surface antigen CD47 (CD47), partial (Active)	CSB-AP005211HU	CD47	Mammalian cell	C-terminal Fc-tagged
Recombinant Human Leukocyte surface antigen CD47 (CD47), partial (Active)	CSB-MP004940HU	CD47	Mammalian cell	C-terminal hFc-tagged
Recombinant Human T-lymphocyte activation antigen CD86 (CD86), partial (Active)	CSB-AP005161HU	CD86	Mammalian cell	C-terminal 6xHis-tagged
Recombinant Human Carcinoembryonic antigen-related cell adhesion molecule 5 (CEACAM5) (E398K) (Active)	CSB-MP005165HU	CEACAM5	Mammalian cell	C-terminal?10xHis-tagged
Recombinant Human Granulocyte-macrophage colony-stimulating factor (CSF2) (Active)	CSB-AP003581HU	CSF2	E.coli	Tag-Free
Recombinant Human Granulocyte-macrophage colony-stimulating factor (CSF2) (Active)	CSB-AP003601HU	CSF2	Mammalian cell	C-terminal 6xHis-tagged
Recombinant Mouse Granulocyte-macrophage colony-stimulating factor (Csf2) (Active)	CSB-AP003651MO	Csf2	Mammalian cell	C-terminal 6xHis-tagged

● 穩(wěn)定細胞株

CT26/Human ROR1 Stable Cell Line

CSB-SC020067HU

Untransfected CT26 cells (green line) and transfected Human ROR1 CT26 stable cells (red line) were stained with anti-ROR1 antibody (CSB-RA020067A1HU) (2μg/1*10⁶ cells), washed and then followed by FITC-conjugated anti-Human IgG Fc antibody and analyzed with flow cytometry.

● 重組抗體

ALB Recombinant Monoclonal Antibody
CSB-RA264109A0HU

Overlay Peak curve showing HepG2 cells stained with CSB-RA264109A0HU (red line) at 1:50.

BTLA Recombinant Monoclonal Antibody
CSB-RA773799MA1HU

Untransfected HEK293T cells (green line) and transfected Human ENPP3 HEK293T Stable cells (red line) were stained with anti-ENPP3 antibody (2μg/1*10⁶ cells).

C5 Recombinant Monoclonal Antibody
CSB-RA003995MA1HU

Overlay Peak curve showing Hela cells surface stained with CSB-RA003995MA1HU (red line) at 1:800.

CD274 Recombinant Monoclonal Antibody
CSB-RA878942MA1HU

Overlay Peak curve showing Hela cells surface stained with CSB-RA878942MA1HU (red line) at 1:100.

產(chǎn)品名稱	貨號	靶點	反應(yīng)種屬	應(yīng)用范圍
ALB Recombinant Monoclonal Antibody	CSB-RA264109A0HU	ALB	Human	ELISA, FC
BTLA Recombinant Monoclonal Antibody	CSB-RA773799MA1HU	BTLA	Human	ELISA, FC
C5 Recombinant Monoclonal Antibody	CSB-RA003995MA1HU	C5	Human	ELISA, FC
CD19 Recombinant Monoclonal Antibody	CSB-RA004888A0HU	CD19	Human	ELISA
CD19 Recombinant Monoclonal Antibody	CSB-RA780821A0HU	CD19	Human	ELISA, WB, IHC, IP
CD19 Recombinant Monoclonal Antibody	CSB-RA004888MA1HU	CD19	Human, Mouse	ELISA, WB
CD247 Recombinant Monoclonal Antibody	CSB-RA244537A0HU	CD247	Human	ELISA, FC
CD27 Recombinant Monoclonal Antibody	CSB-RA953976A0HU	CD27	Human	ELISA, WB
CD274 Recombinant Monoclonal Antibody	CSB-RA977797A0HU	CD274	Human	ELISA, WB, IHC
CD274 Recombinant Monoclonal Antibody	CSB-RA878942MA1HU	CD274	Human	ELISA, IHC, FC
CD38 Recombinant Monoclonal Antibody	CSB-RA796695A0HU	CD38	Human	ELISA, WB, IHC
CD4 Recombinant Monoclonal Antibody	CSB-RA004935A0HU	CD4	Human	ELISA, WB, IHC
CD40 Recombinant Monoclonal Antibody	CSB-RA004936MA1HU	CD40	Human	ELISA, IF, FC
CD44 Recombinant Monoclonal Antibody	CSB-RA004938A0HU	CD44	Human	ELISA, WB, IHC
CD44 Recombinant Monoclonal Antibody	CSB-RA292372A0HU	CD44	Human	ELISA, WB, IHC, IF, FC
CD44 Recombinant Monoclonal Antibody	CSB-RA004938MA1HU	CD44	Human	ELISA, FC
CD47 Recombinant Monoclonal Antibody	CSB-RA802124A0HU	CD47	Human	ELISA, WB, IHC, IF
CD80 Recombinant Monoclonal Antibody	CSB-RA246383A0HU	CD80	Human	ELISA, WB, IHC, IP
CD86 Recombinant Monoclonal Antibody	CSB-RA004965A0HU	CD86	Human	ELISA, WB
CEACAM5 Recombinant Monoclonal Antibody	CSB-RA005165MA3HU	CEACAM5	Human	ELISA, IF, FC

● ELISA試劑盒

產(chǎn)品名稱	貨號	靶點	檢測范圍	靈敏度
Bovine Albumin(Alb) ELISA kit	CSB-E08664b	ALB	0.313 μg/mL-80 μg/mL	0.148 μg/mL
Mouse Albumin (Alb)ELISA Kit	CSB-E13878m	ALB	0.781 μg/mL-200 μg/mL	0.110 μg/mL
Dog Albumin(Alb) ELISA Kit	CSB-E15757c	ALB	0.273 μg/mL-35 μg/mL	0.266 μg/mL
Sheep Albumin (Alb)ELISA Kit	CSB-E15839Sh	ALB	350 μg/mL-21.88 μg/mL	5.5 μg/mL
Horse Albumin(Alb) ELISA Kit	CSB-E16205Hs	ALB	1.25 μg/mL-80 μg/mL	1.247 μg/mL
Pig Albumin (Alb) ELISA Kit	CSB-E16207p	ALB	0.03 μg/mL-7000 μg/mL	0.03 μg/mL
Goat Albumin (Alb)ELISA Kit	CSB-E15758G	ALB	0.17 μg/mL-350 μg/mL	0.17 μg/mL
Guinea Pig Albumin(Alb) ELISA kit	CSB-E15765Gp	ALB	0.156 μg/mL-10 μg/mL	0.09 μg/mL
Rabbit Albumin(Alb) ELISA Kit	CSB-E16204Rb	ALB	0.273 μg/mL-70 μg/mL	0.117 μg/mL
Mouse Membrane primary amine oxidase(AOC3) ELISA kit	CSB-EL001855MO	AOC3	1.25 ng/mL-80 ng/mL	0.31 ng/mL
Rat Membrane primary amine oxidase(AOC3) ELISA kit	CSB-EL001855RA	AOC3	7.8 ng/mL-500 ng/mL	1.95 ng/mL
Human B- and T-lymphocyte attenuator(BTLA) ELISA kit	CSB-EL002868HU	BTLA	0.45 ng/mL-30 ng/mL	0.11 ng/mL
Mouse B- and T-lymphocyte attenuator(BTLA) ELISA kit	CSB-EL002868MO	BTLA	0.625 ng/mL-40 ng/mL	0.156 ng/mL
Human Complement C1s subcomponent(C1S) ELISA kit	CSB-EL003657HU	C1S	25 ng/mL-1600 ng/mL	6.25 ng/mL
Mouse Complement 5,C5 ELISA Kit	CSB-E13802m	C5	0.25 ng/mL-16 ng/mL	0.06 ng/mL
Rat Complement fragment 5,C5 ELISA Kit	CSB-E14363r	C5	9.38 ng/mL-600 ng/mL	2.34 ng/mL
Monkey complement C5 (C5) ELISA kit	CSB-EL003995MK	C5	0.625 ng/mL-40 ng/mL	0.156 ng/mL
Human T-cell surface glycoprotein CD3 zeta chain (CD247) ELISA kit	CSB-EL004904HU	CD247	0.156 ng/mL-10 ng/mL	0.039 ng/mL
Human Programmed Death Ligand-1(PD-L1/CD274) ELISA Kit	CSB-E13644h	CD274	15.6 pg/mL-1000 pg/mL	3.9 pg/mL
Mouse Programmed cell death 1 ligand 1(CD274) ELISA kit	CSB-EL004911MO	CD274	31.25 pg/mL-2000 pg/mL	7.81 pg/mL