神經(jīng)系統(tǒng)疾病

神經(jīng)系統(tǒng)疾病是指影響大腦、脊髓、周?chē)窠?jīng)以及其他神經(jīng)系統(tǒng)組成部分的疾病。這些疾病包括但不限于腦血管疾病、帕金森病、阿爾茨海默病、多發(fā)性硬化癥、癲癇等。

針對(duì)神經(jīng)系統(tǒng)疾病藥物，藥物研發(fā)的策略包括基于表型的藥物發(fā)現(xiàn)（PDD）和基于靶點(diǎn)的藥物發(fā)現(xiàn)（TDD）。PDD通過(guò)生物學(xué)試驗(yàn)和轉(zhuǎn)化醫(yī)學(xué)標(biāo)志物來(lái)發(fā)現(xiàn)具有臨床價(jià)值的藥物，而TDD則側(cè)重于已知靶點(diǎn)的藥物開(kāi)發(fā)。不同疾病對(duì)應(yīng)的藥物靶點(diǎn)如下：

腦血管疾病：血小板聚集、血管緊張素轉(zhuǎn)換酶（ACE）、血管緊張素受體、P2Y12受體等。
帕金森病：多巴胺受體、B型單胺氧化酶（MAO-B）、兒茶酚-O-甲基轉(zhuǎn)移酶（COMT）等。
阿爾茨海默病：β-淀粉樣蛋白（Aβ）、Tau蛋白、乙酰膽堿酯酶（AChE）等。
多發(fā)性硬化癥：S1P受體、干擾素等。
癲癇：電壓門(mén)控鈉通道、GABA受體、AMPA受體等。

神經(jīng)系統(tǒng)疾病藥物靶點(diǎn)

神經(jīng)系統(tǒng)疾病靶點(diǎn)相關(guān)產(chǎn)品推薦

● 靶點(diǎn)蛋白

MAPT
CSB-MP013481HU(F8)

Measured by its binding ability in a functional ELISA. Immobilized Human MAPT at 2 μg/ml can bind Anti-MAPT recombinant antibody (CSB-RA013481A1HU), the EC₅₀ is 4.547-6.284 ng/mL.

GHR
CSB-MP009411HU

Human GH1 protein his/myc tag (CSB-MP009407HU) captured on COOH chip can bind Human GHR protein Fc tag (CSB-MP009411HU) with an affinity constant of 6.1 nM as detected by LSPR Assay.

MS4A1 (CD20)
CSB-MP015007HU

Measured by its binding ability in a functional ELISA. Immobilized human CD20 at 2 μg/ml can bind Anti-CD20 recombinant antibody (CSB-RA015007A1HU), the EC₅₀ is 3.243-7.085 ng/mL

GLP1R
CSB-MP009514HUb1

Measured by its binding ability in a functional ELISA. Immobilized Human GLP1R at 2 μg/mL can bind Anti-GLP1R recombinant antibody (CSB-RA009514MA1HU), the EC₅₀ is 54.54-94.23 ng/mL.

EGFR
CSB-MP007479HU

Human EGF protein captured on COOH chip can bind Human EGFR protein, his and Myc tag (CSB-MP007479HU) with an affinity constant of 11.9nM as detected by LSPR Assay.

PDCD1
CSB-MP619964HU1

Measured by its binding ability in a functional ELISA. Immobilized PD-1 at 2 μg/ml can bind Anti-PD-1 recombinant antibody, the EC₅₀ of human PD-1 protein is 6.087-7.854 ng/ml.

CD40LG
CSB-MP004937HU3

Human CD40 protein hFc tag (CSB-MP004936HU1) captured on COOH chip can bind Human CD40L protein hFc and Flag tag (CSB-MP004937HU3) with an affinity constant of 2.06 nM as detected by LSPR Assay.

CD274
CSB-MP878942HU1

Measured by its binding ability in a functional ELISA. Immobilized PD-L1 at 2 μg/ml can bind Anti- PD-L1 mouse monoclonal antibody (CSB-MA878942A1m, antigen from E.coli), the EC₅₀ of human PD-L1 protein is 1.252-1.653 ng/mL

產(chǎn)品名稱	貨號(hào)	靶點(diǎn)	來(lái)源	蛋白標(biāo)簽
Recombinant Human ATP-binding cassette sub-family D member 1 (ABCD1) (Active)	CSB-CF001068HU	ABCD1	in vitro E.coli expression system	C-terminal 10xHis-tagged
Recombinant Human Activin receptor type-2B (ACVR2B), partial (Active)	CSB-AP005701HU	ACVR2B	Mammalian cell	C-terminal 6xHis-Fc-tagged
Recombinant Human Angiopoietin-2 (ANGPT2) (Active)	CSB-MP001707HU(A4)	ANGPT2	Mammalian cell	C-terminal 10xHis-tagged
Recombinant Dog Angiopoietin-2 (ANGPT2) (Active)	CSB-MP001707DO	ANGPT2	Mammalian cell	C-terminal 6xHis-tagged
Recombinant Human B-lymphocyte antigen CD19 (CD19), partial (Active)	CSB-AP005061HU	CD19	Mammalian cell	C-terminal Fc-tagged
Recombinant Human Programmed cell death 1 ligand 1 (CD274), partial (Active)	CSB-MP878942HU1	CD274	Mammalian cell	C-terminal hFc-tagged
Recombinant Human CD276 antigen (CD276), partial (Active)	CSB-MP733578HU	CD276	Mammalian cell	C-terminal hFc-Myc-tagged
Recombinant Human Myeloid cell surface antigen CD33 (CD33), partial (Active)	CSB-MP004925HU	CD33	Mammalian cell	C-terminal hFc-Myc-tagged
Recombinant Human Tumor necrosis factor receptor superfamily member 5 (CD40), partial (Active)	CSB-AP005181HU	CD40	Mammalian cell	C-terminal Fc-tagged
Recombinant Human Tumor necrosis factor receptor superfamily member 5 (CD40), partial (Active)	CSB-MP004936HU1	CD40	Mammalian cell	C-terminal hFc-tagged
Recombinant Human CD40 ligand (CD40LG), partial (Active)	CSB-AP005191HU	CD40LG	E.coli	Tag-Free
Recombinant Human CD40 ligand (CD40LG), partial (Active)	CSB-MP004937HU3	CD40LG	Mammalian cell	N-terminal hFc-Flag-tagged
Recombinant Human Leukocyte surface antigen CD47 (CD47), partial (Active)	CSB-AP005201HU	CD47	Mammalian cell	C-terminal 6xHis-tagged
Recombinant Human Leukocyte surface antigen CD47 (CD47), partial (Active)	CSB-AP005211HU	CD47	Mammalian cell	C-terminal Fc-tagged
Recombinant Human Leukocyte surface antigen CD47 (CD47), partial (Active)	CSB-MP004940HU	CD47	Mammalian cell	C-terminal hFc-tagged
Recombinant Human Granulocyte-macrophage colony-stimulating factor receptor subunit alpha (CSF2RA), partial (Active)	CSB-AP003591HU	CSF2RA	Mammalian cell	C-terminal 6xHis-tagged
Recombinant Guinea pig Cytotoxic T-lymphocyte associated protein 4 (CTLA4), partial (Active)	CSB-AP005121GU	CTLA4	Yeast	C-terminal 6xHis-tagged
Recombinant Human Cytotoxic T-lymphocyte protein 4 (CTLA4), partial (Active)	CSB-AP005231HU	CTLA4	Mammalian cell	C-terminal 6xHis-tagged
Recombinant Mouse Cytotoxic T-lymphocyte protein 4 (Ctla4), partial (Active)	CSB-AP005301MO	Ctla4	Mammalian cell	C-terminal 6xHis-tagged
Recombinant Human Cytotoxic T-lymphocyte protein 4 (CTLA4), partial (Active)	CSB-MP006163HU1	CTLA4	Mammalian cell	C-terminal hFc-tagged

● 穩(wěn)定細(xì)胞株

HEK293T/Human SEMA4D Stable Cell Line

CSB-SC835707HU

Untransfected HEK293T cells (green line) and transfected Human SEMA4D HEK293T stable cells (red line) were stained with anti-SEMA4D antibody (CSB-RA835707A2HU) (2μg/1*10 ⁶), washed and then followed by FITC-conjugated anti-Human IgG Fc antibody and analyzed with flow cytometry.

● 重組抗體

C3 Recombinant Monoclonal Antibody
CSB-RA303909A0HU

Overlay histogram showing HepG2 cells stained with CSB-RA303909A0HU (red line) at 1:50.

CD274 Recombinant Monoclonal Antibody
CSB-RA878942MA1HU

Overlay Peak curve showing Hela cells surface stained with CSB-RA878942MA1HU (red line) at 1:100.

EGFR Recombinant Monoclonal Antibody
CSB-RA159341A0HU

Overlay histogram showing Jurkat cells stained with CSB-RA159341A0HU (red line) at 1:50.

MAPT Recombinant Monoclonal Antibody
CSB-RA013481MA1HU

Overlay Peak curve showing MCF7 cells stained with CSB-RA013481MA1HU (red line) at 1:100.

產(chǎn)品名稱	貨號(hào)	靶點(diǎn)	反應(yīng)種屬	應(yīng)用范圍
ACVR2B Recombinant Monoclonal Antibody	CSB-RA260702A0HU	ACVR2B	Human	ELISA, IHC
ALB Recombinant Monoclonal Antibody	CSB-RA264109A0HU	ALB	Human	ELISA, FC
ANGPT2 Recombinant Monoclonal Antibody	CSB-RA191985A0HU	ANGPT2	Human	ELISA, IHC
ANGPT2 Recombinant Monoclonal Antibody	CSB-RA001707MA01HU	ANGPT2	Human	ELISA
APP Recombinant Monoclonal Antibody	CSB-RA994273A0HU	APP	Human, Mouse, Rat	ELISA, WB, IF
C3 Recombinant Monoclonal Antibody	CSB-RA303909A0HU	C3	Human	ELISA, WB, IHC, FC
C3 Recombinant Monoclonal Antibody	CSB-RA699863A0HU	C3	Human	ELISA, IHC
C5 Recombinant Monoclonal Antibody	CSB-RA003995MA1HU	C5	Human	ELISA, FC
CD19 Recombinant Monoclonal Antibody	CSB-RA004888A0HU	CD19	Human	ELISA
CD19 Recombinant Monoclonal Antibody	CSB-RA780821A0HU	CD19	Human	ELISA, WB, IHC, IP
CD19 Recombinant Monoclonal Antibody	CSB-RA004888MA1HU	CD19	Human, Mouse	ELISA, WB
CD247 Recombinant Monoclonal Antibody	CSB-RA244537A0HU	CD247	Human	ELISA, FC
CD274 Recombinant Monoclonal Antibody	CSB-RA977797A0HU	CD274	Human	ELISA, WB, IHC
CD274 Recombinant Monoclonal Antibody	CSB-RA878942MA1HU	CD274	Human	ELISA, IHC, FC
CD38 Recombinant Monoclonal Antibody	CSB-RA796695A0HU	CD38	Human	ELISA, WB, IHC
CD3E Recombinant Monoclonal Antibody	CSB-RA004931MA1HU	CD3E	Human	ELISA, FC
CD4 Recombinant Monoclonal Antibody	CSB-RA004935A0HU	CD4	Human	ELISA, WB, IHC
CD40 Recombinant Monoclonal Antibody	CSB-RA004936MA1HU	CD40	Human	ELISA, IF, FC
CD47 Recombinant Monoclonal Antibody	CSB-RA802124A0HU	CD47	Human	ELISA, WB, IHC, IF
CD80 Recombinant Monoclonal Antibody	CSB-RA246383A0HU	CD80	Human	ELISA, WB, IHC, IP

● ELISA試劑盒

產(chǎn)品名稱	貨號(hào)	靶點(diǎn)	檢測(cè)范圍	靈敏度
Bovine Albumin(Alb) ELISA kit	CSB-E08664b	ALB	0.313 μg/mL-80 μg/mL	0.148 μg/mL
Mouse Albumin (Alb)ELISA Kit	CSB-E13878m	ALB	0.781 μg/mL-200 μg/mL	0.110 μg/mL
Dog Albumin(Alb) ELISA Kit	CSB-E15757c	ALB	0.273 μg/mL-35 μg/mL	0.266 μg/mL
Sheep Albumin (Alb)ELISA Kit	CSB-E15839Sh	ALB	350 μg/mL-21.88 μg/mL	5.5 μg/mL
Horse Albumin(Alb) ELISA Kit	CSB-E16205Hs	ALB	1.25 μg/mL-80 μg/mL	1.247 μg/mL
Pig Albumin (Alb) ELISA Kit	CSB-E16207p	ALB	0.03 μg/mL-7000 μg/mL	0.03 μg/mL
Goat Albumin (Alb)ELISA Kit	CSB-E15758G	ALB	0.17 μg/mL-350 μg/mL	0.17 μg/mL
Guinea Pig Albumin(Alb) ELISA kit	CSB-E15765Gp	ALB	0.156 μg/mL-10 μg/mL	0.09 μg/mL
Rabbit Albumin(Alb) ELISA Kit	CSB-E16204Rb	ALB	0.273 μg/mL-70 μg/mL	0.117 μg/mL
Human Angiopoietin 2,ANG-2 ELISA Kit	CSB-E04500h	ANGPT2	39 pg/mL-2500 pg/mL	9.75 pg/mL
Rat Angiopoietin 2,ANG-2 ELISA Kit	CSB-E07304r	ANGPT2	Request Information	Request Information
Mouse Angiopoietin 2,ANG-2 ELISA Kit	CSB-E07305m	ANGPT2	0.156 pg/mL-10 pg/mL	0.039 pg/mL
Pig Angiopoietin 2,ANG-2 ELISA Kit	CSB-E08460p	ANGPT2	0.94 ng/mL-60 ng/mL	0.235 ng/mL
Human apolipoprotein E (Apo-E) ELISA Kit	CSB-E09748h	APOE	15.62 ng/mL-1000 ng/mL	3.9 ng/mL
Rat apolipoprotein E (Apo-E) ELISA Kit	CSB-E09749r	APOE	15.6 ng/mL-1000 ng/mL	15.6 ng/mL
Mouse apolipoprotein E (Apo-E) ELISA Kit	CSB-E09750m	APOE	6.25 ng/mL-400 ng/mL	1.56 ng/mL
Pig apolipoprotein E (Apo-E) ELISA Kit	CSB-E17889p	APOE	31.25 ng/mL-2000 ng/mL	7.81 ng/mL
Monkey Apolipoprotein E(APOE) ELISA kit	CSB-EL001936RH	APOE	6.25 ng/mL-400 ng/mL	1.56 ng/mL
Rat Amyloid beta A4 protein(APP) ELISA kit	CSB-EL001950RA	APP	15.6 ng/mL-1000 ng/mL	3.9 ng/mL
Human Complement C1s subcomponent(C1S) ELISA kit	CSB-EL003657HU	C1S	25 ng/mL-1600 ng/mL	6.25 ng/mL