APP
APP（Amyloid Precursor Protein）的主要功能是參與神經細胞的生長、發育和修復，并影響突觸形成和可塑性。他的結構包括一個N端信號肽、大約660個氨基酸組成的外顯區域，以及一個C端跨膜區和胞內區域。在正常情況下，APP會通過非淀粉樣途徑被酶解，產生具有生理功能的代謝產物。然而，異常的代謝途徑可能導致β-淀粉樣蛋白（β-amyloid）的積聚，這是阿爾茨海默病的主要病理特征之一。APP信號通路涉及多種酶的參與，包括α、β和γ-分泌酶。這些酶的活性和調控對APP代謝產物的生成和去除至關重要。在研究和臨床應用方面，APP和其代謝產物被廣泛用于阿爾茨海默病的診斷和治療研究。
熱銷產品
APP Recombinant Monoclonal Antibody (Code:CSB-RA994273A0HU)
驗證數據
Positive WB detected in: Hela whole cell lysate, A375 whole cell lysate, HEK293 whole cell lysate, Rat Brain whole cell lysate, Mouse Brain whole cell lysate
All lanes: Amyloid beta A4 antibody at 1:1000
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 87, 35, 77, 79, 79, 81, 83, 85, 86, 73, 85 kDa
Observed band size: 100 kDa
Immunofluorescence staining of Hela Cells with CSB-RA994273A0HU at 1:50, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeated by 0.2% TritonX-100, and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4℃. Nuclear DNA was labeled in blue with DAPI. The secondary antibody was FITC-conjugated AffiniPure Goat Anti-Rabbit IgG (H+L).
APP Antibodies
APP for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 種屬反應性 | 應用類型 |
|---|---|---|---|
| CSB-PA07174A0Rb | APP Antibody | Human | ELISA, IHC |
| CSB-PA07174B0Rb | APP Antibody, HRP conjugated | Human | ELISA |
| CSB-PA07174C0Rb | APP Antibody, FITC conjugated | Human | |
| CSB-PA07174D0Rb | APP Antibody, Biotin conjugated | Human | ELISA |
| CSB-PA001950GA01HU | APP Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-PA001950OJ01HU | APP Antibody | Human, Mouse | ELISA, WB, IHC, IF |
| CSB-PA001950NJ01HU | APP Antibody | Human | ELISA, WB |
| CSB-PA07179A0Rb | APP Antibody | Human, Mouse | ELISA, WB, IHC, IF |
| CSB-PA07179B0Rb | APP Antibody, HRP conjugated | Human | ELISA |
| CSB-PA07179C0Rb | APP Antibody, FITC conjugated | Human | |
| CSB-PA07179D0Rb | APP Antibody, Biotin conjugated | Human | ELISA |
| CSB-MA0019501A0m | APP Monoclonal Antibody | Human, Mouse | ELISA, WB, IHC, IF |
| CSB-PA296382 | Phospho-APP (Thr668) Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-PA907645 | APP (Ab-668) Antibody | Human,Mouse,Rat | ELISA,WB,IF |
| CSB-PA212801 | Phospho-APP (Thr743/668) Antibody | Human,Mouse,Rat | ELISA,WB,IHC,IF |
| CSB-PA000724 | Phospho-APP (T743) Antibody | Human,Mouse,Rat | WB, IHC, IF, ELISA |
| CSB-PA000875 | APP Antibody | Human,Mouse,Rat | WB, IHC, IF, ELISA |
| CSB-PA123968 | APP Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-RA994273A0HU | APP Recombinant Monoclonal Antibody | Human, Mouse, Rat | ELISA, WB, IF |
| CSB-RA001950MA2HU | APP (GSK933776) Recombinant Monoclonal Antibody | Human | ELISA, IHC, IF |
| CSB-RA001950MA3HU | APP (sabirnetug) Recombinant Monoclonal Antibody | Human | ELISA, IF, FC |
APP Proteins
APP Proteins for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-CF001950HU | Recombinant Human Amyloid-beta precursor protein（APP） | in vitro E.coli expression system |
