SEMA4D
SEMA4D是一種跨膜蛋白，包括一個胞外區域、一個跨膜區域和一個胞漿區域。它的胞外區域包含Semaphorin結構域，用于與其他蛋白質相互作用，觸發信號傳導。 SEMA4D在神經發育中發揮關鍵作用。它參與了神經軸突的引導和突觸形成。通過與其受體（如Plexin家族受體）的相互作用，SEMA4D可以影響神經元的生長和連接。SEMA4D也在免疫系統中具有重要作用。它可以調節免疫細胞的活化和遷移。SEMA4D和其受體（如CD72和Plexin B2）之間的相互作用可以影響T細胞、B細胞和巨噬細胞的功能。SEMA4D是一個多功能的分子，在神經發育、免疫系統和疾病中都發揮作用。研究SEMA4D的功能和調控機制有助于我們更好地理解神經發育和免疫應答的調控，同時也有助于開發新的治療方法，尤其是在癌癥等疾病領域。
更多相關閱讀：新興SEMA4D抑制劑嶄露頭角，克服免疫治療耐藥難題？
熱銷產品
● Recombinant Human Semaphorin-4D(SEMA4D),partial (Active) CSB-MP835707HU
驗證數據
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Activity: Measured by its binding ability in a functional ELISA. Immobilized human SEMA4D at 2 μg/ml can bind Pepinemab, the EC50 is 4.035-5.743 ng/mL.
● Recombinant Mouse Semaphorin-4D(Sema4d),partial (Active) CSB-MP020990MO
驗證數據
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Activity: Measured by its binding ability in a functional ELISA. Immobilized Pepinemab at 2 μg/ml can bind Mouse Sema4d, the EC50 is 4.878-7.446 ng/ml.
● Recombinant Human Semaphorin-4D(SEMA4D),partial (Active) CSB-MP835707HUd9
驗證數據
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Activity: Measured by its binding ability in a functional ELISA. Immobilized human SEMA4D at 2 μg/ml can bind biotinylated Pepinemab, the EC50 is 1.005-1.776 ng/mL.
Activity: Measured by its binding ability in a functional ELISA. Immobilized human SEMA4D at 5 μg/ml can bind human PLXNB1 (CSB-MP018222HU2k6), the EC50 is 0.8179-1.357 μg/mL.
● Recombinant Macaca mulatta Semaphorin-4D isoform 1(SEMA4D),partial (Active) CSB-MP3947MOW
驗證數據
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Activity: Measured by its binding ability in a functional ELISA. Immobilized Rhesus macaque SEMA4D at 2 μg/mL can bind Anti-SEMA4D recombinant antibody (CSB-RA835707A1HU), the EC50 is 1.943-2.724 ng/mL.
● SEMA4D Recombinant Monoclonal Antibody CSB-RA835707A2HU
驗證數據
The Binding Activity of Mouse Sema4d with Anti-SEMA4D recombinant antibody
Activity: Measured by its binding ability in a functional ELISA. Immobilized Anti-SEMA4D recombinant antibody at 2 μg/mL can bind Mouse Sema4d (CSB-MP020990MO), the EC50 is 5.829-16.86 ng/mL.
The Binding Activity of Human SEMA4D with Anti-SEMA4D recombinant antibody
Activity: Measured by its binding ability in a functional ELISA. Immobilized Human SEMA4D (CSB-MP835707HU) at 2 μg/mL can bind Anti- SEMA4D recombinant antibody, the EC50 is 60.38-152.6 ng/mL.
Untransfected HEK293T cells (green line) and transfected Human SEMA4D HEK293T stable cells (red line) were stained with anti-SEMA4D antibody (2μg/1*106cells), washed and then followed by FITC-conjugated anti-Human IgG Fc antibody and analyzed with flow cytometry.
● SEMA4D Recombinant Monoclonal Antibody CSB-RA835707A1HU
驗證數據
Untransfected HEK293T cells (green line) and transfected Human SEMA4D HEK293T stable cells (red line) were stained with anti-SEMA4D antibody (2μg/1*106 cells), washed and then followed by FITC-conjugated anti-Human IgG Fc antibody and analyzed with flow cytometry.
The Binding Activity of Mouse Sema4d with Anti-SEMA4D recombinant antibody.
Activity: Measured by its binding ability in a functional ELISA. Immobilized Mouse Sema4d (CSB-MP020990MO) at 2 μg/mL can bind Anti-SEMA4D recombinant antibody, the EC50 is 98.14-174.8 ng/mL.
The Binding Activity of Human SEMA4D with Anti-SEMA4D recombinant antibody.
Activity: Measured by its binding ability in a functional ELISA. Immobilized Human SEMA4D (CSB-MP835707HU) at 2 μg/mL can bind Anti-SEMA4D recombinant antibody, the EC50 is 1.082-4.805 ng/mL.
● HEK293T/Human SEMA4D Stable Cell Line CSB-SC835707HU
驗證數據
Untransfected HEK293T cells (green line) and transfected Human SEMA4D HEK293T stable cells (red line) were stained with anti-SEMA4D antibody (CSB-RA835707A2HU) (2μg/1*106cells), washed and then followed by FITC-conjugated anti-Human IgG Fc antibody and analyzed with flow cytometry.
SEMA4D Antibodies
SEMA4D for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 種屬反應性 | 應用類型 |
|---|---|---|---|
| CSB-PA005238 | SEMA4D Antibody | Human,Mouse,Rat | WB, ELISA |
| CSB-PA835707LA01HU | SEMA4D Antibody | Human | ELISA, IF |
| CSB-PA835707LB01HU | SEMA4D Antibody, HRP conjugated | Human | ELISA |
| CSB-PA835707LC01HU | SEMA4D Antibody, FITC conjugated | Human | |
| CSB-PA835707LD01HU | SEMA4D Antibody, Biotin conjugated | Human | ELISA |
| CSB-RA835707A1HU | SEMA4D Recombinant Monoclonal Antibody | Human | ELISA, FC |
| CSB-MA835707A0m | SEMA4D Monoclonal Antibody | Human | ELISA, WB, FC |
| CSB-RA835707A2HU | SEMA4D Recombinant Monoclonal Antibody | Human, Mouse | ELISA, FC |
SEMA4D Proteins
SEMA4D Proteins for Mus musculus (Mouse)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP020990MO CSB-EP020990MO CSB-BP020990MO CSB-EP020990MO-B |
Recombinant Mouse Semaphorin-4D (Sema4d), partial | Yeast E.coli Baculovirus In Vivo Biotinylation in E.coli |
| CSB-MP020990MO | Recombinant Mouse Semaphorin-4D (Sema4d), partial (Active) | Mammalian cell |
SEMA4D Proteins for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP835707HU CSB-EP835707HU CSB-BP835707HU CSB-EP835707HU-B |
Recombinant Human Semaphorin-4D (SEMA4D), partial | Yeast E.coli Baculovirus In Vivo Biotinylation in E.coli |
| CSB-MP835707HU | Recombinant Human Semaphorin-4D (SEMA4D), partial (Active) | Mammalian cell |
| CSB-MP835707HUd9 | Recombinant Human Semaphorin-4D (SEMA4D), partial (Active) | Mammalian cell |
SEMA4D Proteins for Gallus gallus (Chicken)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP856186CH CSB-EP856186CH CSB-BP856186CH CSB-MP856186CH CSB-EP856186CH-B |
Recombinant Chicken Semaphorin-4D (SEMA4D) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
SEMA4D ELISA Kit
SEMA4D ELISA Kit for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-E15792h | Human soluble Cluster of differentiation 100(sCD100)ELISA kit | serum, plasma, tissue homogenates | 31.25 pg/mL |
