FOLR1
FOLR1（葉酸受體1）是一種成人葉酸受體，也稱為葉酸結(jié)合蛋白（FBP），由FOLR1基因編碼。這種膜結(jié)合糖蛋白對(duì)葉酸和幾種還原葉酸衍生物具有高親和力，主要功能是介導(dǎo)5-甲基四氫葉酸的細(xì)胞內(nèi)運(yùn)輸，對(duì)細(xì)胞生長(zhǎng)和增殖至關(guān)重要。FOLR1的結(jié)構(gòu)包括跨膜結(jié)構(gòu)域，并存在膜結(jié)合和可溶性兩種形式。 除了在葉酸轉(zhuǎn)運(yùn)中的基本作用外，F(xiàn)OLR1還參與了多種信號(hào)通路，包括JAK-STAT3、ERK1/2信號(hào)通路，并可能作為轉(zhuǎn)錄因子參與基因表達(dá)調(diào)控。FOLR1在Wnt和ERK信號(hào)通路中發(fā)揮作用，通過增加活性β-catenin、磷酸化ERK以及Wnt和ERK調(diào)控基因的表達(dá)。此外，F(xiàn)OLR1還可能參與Wnt和TGFβ信號(hào)通路。 FOLR1的異常表達(dá)與多種癌癥的發(fā)生、發(fā)展密切相關(guān)，其在腫瘤細(xì)胞中的高表達(dá)通常與癌癥進(jìn)展加快和患者預(yù)后不良有關(guān)。因此，F(xiàn)OLR1不僅是癌癥治療研究中的潛在靶點(diǎn)，而且在葉酸受體靶向治療領(lǐng)域具有重要的應(yīng)用前景。
熱銷產(chǎn)品
Recombinant Human Folate receptor alpha(FOLR1),partial (Active) (CSB-MP008784HU1)
驗(yàn)證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Activity
Measured by its binding ability in a functional ELISA. Immobilized human FOLR1 at 2 μg/ml can bind Anti-FOLR1 recombinant antibody(CSB-RA008784MA1HU). The EC50 is 6.893-7.883 ng/mL.
The purity of FOLR1 was greater than 95% as determined by SEC-HPLC
Recombinant Macaca fascicularis Folate receptor alpha(FOLR1),partial (Active) (CSB-MP5002MOV)
驗(yàn)證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Activity
Measured by its binding ability in a functional ELISA. Immobilized Cynomolgus FOLR1 at 2 μg/ml can bind Anti-FOLR1 recombinant antibody(CSB-RA008784MA1HU). The EC50 is 2.900-3.544 ng/mL.
FOLR1 Antibodies
FOLR1 for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA008378 | FOLR1 Antibody | Human,Mouse,Rat | WB, ELISA |
| CSB-PA008784LA01HU | FOLR1 Antibody | Human | ELISA, IHC, IF |
| CSB-PA008784LB01HU | FOLR1 Antibody, HRP conjugated | Human | ELISA |
| CSB-PA008784LC01HU | FOLR1 Antibody, FITC conjugated | Human | |
| CSB-PA008784LD01HU | FOLR1 Antibody, Biotin conjugated | Human | ELISA |
FOLR1 Proteins
FOLR1 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP008784HU CSB-EP008784HU CSB-MP008784HU CSB-EP008784HU-B |
Recombinant Human Folate receptor alpha (FOLR1) | Yeast E.coli Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-MP008784HU1 | Recombinant Human Folate receptor alpha(FOLR1),partial (Active) | Mammalian cell |
FOLR1 Proteins for Mus musculus (Mouse)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP008784MO CSB-EP008784MO CSB-BP008784MO CSB-MP008784MO CSB-EP008784MO-B |
Recombinant Mouse Folate receptor alpha (Folr1) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
FOLR1 Proteins for Bos taurus (Bovine)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP008784BO CSB-EP008784BO CSB-BP008784BO CSB-MP008784BO CSB-EP008784BO-B |
Recombinant Bovine Folate receptor alpha (FOLR1) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
FOLR1 ELISA Kit
FOLR1 ELISA Kit for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-EL008784HU | Human Folate receptor alpha(FOLR1) ELISA kit | serum, plasma, tissue homogenates | 0.09 ng/ml |
