BAFF
BAFF（B細胞激活因子）是一種由髓系細胞產生的細胞因子，屬于腫瘤壞死因子家族，對B細胞的存活、增殖、抗原呈遞以及類別轉換重組起著至關重要的作用。它通過與三種受體（TNFRSF13B/TACI、TNFRSF17/BCMA、TNFRSF13C/BAFFR）結合，激活多種信號通路，包括NF-κB、MAPK（絲裂原活化蛋白激酶）和PI3K/AKT等，這些信號通路在B細胞的生物學過程以及免疫調節中發揮著重要作用。然而，BAFF的過度產生和激活也可能導致自身免疫性疾病的發生。因此，對BAFF的結構功能及其參與的信號通路的深入研究，對于理解其在免疫系統中的作用機制以及開發相關疾病的治療方法具有重要意義。
熱銷產品
驗證數據
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Activity
Measured by its binding ability in a functional ELISA. Immobilized TNFSF13B at 10 μg/ml can bind human BCMA (CSB-MP023974HU1), the EC50 of human TNFSF13B protein is 221.3-298.6 ng/ml.
Human TNFSF13B protein Fc tag (CSB-MP897523HU1) captured on COOH chip can bind Human BCMA protein Fc tag (CSB-MP023974HU1) with an affinity constant of 39 nM as detected by LSPR Assay.
Activity
Measured by its binding ability in a functional ELISA. Immobilized TNFSF13B at 2 μg/ml can bind TNFRSF13C(CSB-MP853495HU1), the EC50 is 9.943-15.72 ng/ml.
The purity of TNFSF13B was greater than 90% as determined by SEC-HPLC
BAFF Antibodies
BAFF for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 種屬反應性 | 應用類型 |
|---|---|---|---|
| CSB-PA023990GA01HU | TNFSF13B Antibody | Human | ELISA,WB |
| CSB-PA05767A0Rb | TNFSF13B Antibody | Human | ELISA |
| CSB-PA897523ESR2HU | TNFSF13B Antibody | Human, Mouse | ELISA, WB, IHC |
| CSB-PA005018 | TNFSF13B Antibody | Human,Mouse | WB, ELISA |
| CSB-PA981923 | TNFSF13B Antibody | Human | ELISA,WB,IHC |
| CSB-PA108957 | TNFSF13B Antibody | Human | ELISA,IHC |
BAFF Proteins
BAFF Proteins for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP897523HU CSB-BP897523HU CSB-MP897523HU CSB-EP897523HU-B |
Recombinant Human Tumor necrosis factor ligand superfamily member 13B (TNFSF13B), partial | Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-EP897523HU | Recombinant Human Tumor necrosis factor ligand superfamily member 13B protein (TNFSF13B), partial | E.coli |
| CSB-AP002191HU | Recombinant Human Tumor necrosis factor ligand superfamily member 13B (TNFSF13B), partial (Active) | E.Coli |
| CSB-MP897523HU1 | Recombinant Human Tumor necrosis factor ligand superfamily member 13B (TNFSF13B), partial (Active) | Mammalian cell |
| CSB-MP897523HU1-B | Recombinant Human Tumor necrosis factor ligand superfamily member 13B (TNFSF13B), partial,Biotinylated (Active) | Mammalian cell |
BAFF ELISA Kit
BAFF ELISA Kit for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-E11912h | Human B cell activation factor，BAFF ELISA Kit | serum, plasma, tissue homogenates | 0.078 ng/mL |
