CEACAM5

CEACAM5，即癌胚抗原細胞黏附分子5，別名CD66e，由人類CEACAM5基因編碼，該基因位于染色體19q13.2，基因長度約為21kb，由9個外顯子和3個非編碼外顯子組成。CEACAM5通過糖基磷脂酰肌醇（GPI）與膜結合，胞外共有7個免疫球蛋白樣結構域，包括一個可變（IgV）樣結構域和6個IgC樣結構域（A1-B3）。
CEACAM5在多種生物學過程中發揮作用，包括細胞黏附、細胞信號轉導和免疫調節等，并在許多惡性腫瘤細胞中高表達，被廣泛用于癌癥的診斷和監測。CEACAM5的表達異常與多種癌癥的發生發展相關，尤其在結直腸癌、胃癌、肺癌和胰腺癌中過表達，是潛在的癌癥治療靶點。

熱銷產品

Recombinant Human Carcinoembryonic antigen-related cell adhesion molecule 5 (CEACAM5) (E398K) (Active) (CSB-MP005165HU)

驗證數據

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

Activity
Measured by its binding ability in a functional ELISA. Immobilized Human CEACAM5 at 2μg/mL can bind Anti-CEACAM5 recombinant antibody (CSB-RA005165MA1HU), the EC₅₀ is 0.8955-1.719 ng/mL.

Recombinant Macaca mulatta Carcinoembryonic antigen-related cell adhesion molecule 5(CEACAM5),partial (Active) (CSB-MP5152MOW)

驗證數據

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

Activity
Measured by its binding ability in a functional ELISA. Immobilized Cynomolgus CEACAM5 at 2μg/ml can bind Anti-CEACAM5 recombinant antibody (CSB-RA005165MA4HU). The EC₅₀ is 3.572-4.044 ng/mL.

The purity of CEACAM5 was greater than 95% as determined by SEC-HPLC

CEACAM5 Recombinant Monoclonal Antibody (CSB-RA005165MA3HU)

驗證數據

Immunofluorescence staining of Hela cell with CSB-RA005165MA3HU at 1:150, counter-stained with DAPI. The cells were fixed in 4% formaldehyde and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4C. The secondary antibody was FITC-conjugated AffiniPure Goat Anti-human IgG(H+L).

Immunofluorescence staining of MCF7 cell with CSB-RA005165MA3HU at 1:150, counter-stained with DAPI. The cells were fixed in 4% formaldehyde and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4C. The secondary antibody was FITC-conjugated AffiniPure Goat Anti-human IgG(H+L).

Overlay Peak curve showing Hela cells surface stained with CSB-RA005165MA3HU (red line) at 1:100. Then 10% normal goat serum was Incubated to block non-specific protein-protein interactions followed by the antibody (1μg/1*10⁶cells) for 45 min at 4°C. The secondary antibody used was FITC-conjugated Goat Anti-human IgG(H+L) at 1/200 dilution for 35 min at 4°C. Isotype control antibody (green line) was human IgG1 (1μg/1*10⁶cells) used under the same conditions. Acquisition of >10,026 events was performed.

CEACAM5 Antibody

CEACAM5 Protein

CEACAM5 ELISA Kit

CEACAM5 Antibodies

CEACAM5 for H

產品貨號	產品名稱	種屬反應性	應用類型
CSB-MA000218	CEACAM5 Monoclonal Antibody	Human	ELISA,IHC

CEACAM5 for Homo sapiens (Human)

產品貨號	產品名稱	種屬反應性	應用類型
CSB-PA005033	CEACAM5 Antibody	Human	WB, ELISA
CSB-PA160116	CEACAM5 Antibody	Human	ELISA,WB,IHC
CSB-PA229032	CEACAM5 Antibody	Human	ELISA,WB,IHC
CSB-PA109108	CEACAM5 Antibody	Human	ELISA,IHC
CSB-PA097333	CEACAM5 Antibody	Human	ELISA,IHC
CSB-PA005165LA01HU	CEACAM5 Antibody	Human	ELISA, WB, IHC, IF
CSB-PA005165LB01HU	CEACAM5 Antibody, HRP conjugated	Human	ELISA
CSB-PA005165LC01HU	CEACAM5 Antibody, FITC conjugated	Human
CSB-PA005165LD01HU	CEACAM5 Antibody, Biotin conjugated	Human	ELISA
CSB-MA995583	CEACAM5 Monoclonal Antibody	Human	ELISA, IHC
CSB-RA005165MA3HU	CEACAM5 Recombinant Monoclonal Antibody	Human	ELISA, IF, FC
CSB-RA005165MA1HU	CEACAM5 (labetuzumab) Recombinant Monoclonal Antibody	Human	ELISA

CEACAM5 Proteins

CEACAM5 Proteins for Homo sapiens (Human)

產品貨號	產品名稱	來源
CSB-YP005165HU	Recombinant Human Carcinoembryonic antigen-related cell adhesion molecule 5 (CEACAM5) (E398K)	Yeast
CSB-MP005165HU	Recombinant Human Carcinoembryonic antigen-related cell adhesion molecule 5 (CEACAM5) (E398K) (Active)	Mammalian cell

CEACAM5 Proteins for Mus musculus (Mouse)

產品貨號	產品名稱	來源
CSB-YP005165MO CSB-EP005165MO CSB-BP005165MO CSB-EP005165MO-B	Recombinant Mouse Carcinoembryonic antigen-related cell adhesion molecule 5 (Ceacam5), partial	Yeast E.coli Baculovirus In Vivo Biotinylation in E.coli