ERBB3
ERBB3，即人表皮生長因子受體3，別名HER3、CD340。ERBB3蛋白是一種酪氨酸激酶受體，屬于表皮生長因子受體家族，能與其他EGFR家族成員形成異源二聚體，從而激活下游信號通路，包括PI3K/AKT和MAPK/ERK通路，這些通路在細胞增殖、分化和生存中發(fā)揮重要作用。
ERBB3在多種正常生理過程中和腫瘤發(fā)展中扮演著關鍵角色，其過表達與多種癌癥（如乳腺癌、肺癌、結直腸癌等）的發(fā)生和進展密切相關，尤其是在HER2陽性乳腺癌中。ERBB3與HER2的相互作用被認為是腫瘤細胞增殖和轉(zhuǎn)移的促進因素。ERBB3是癌癥治療的重要靶點，靶向ERBB3的治療策略正在被廣泛研究，以期改善患者的預后和治療效果。
熱銷產(chǎn)品
Recombinant Human Receptor tyrosine-protein kinase erbB-3 (ERBB3), partial (Active) (CSB-MP007765HU)
驗證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Activity
Measured by its binding ability in a functional ELISA. Immobilized NRG1(CSB-MP016077HU1(F6)) at 2 μg/ml can bind human ERBB3, the EC50 is 12.32-15.74 ng/ml.
EGFR Recombinant Monoclonal Antibody (CSB-RA159341MA1HU)
驗證數(shù)據(jù)
IHC image of CSB-RA159341MA1HU diluted at 1:50 and staining in paraffin-embedded human lung cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-rabbit polymer IgG labeled by HRP and visualized using 0.05% DAB.
IHC image of CSB-RA159341MA1HU diluted at 1:50 and staining in paraffin-embedded human pancreatic tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-rabbit polymer IgG labeled by HRP and visualized using 0.05% DAB.
Overlay Peak curve showing NIH/3T3 cells stained with CSB-RA159341MA1HU (red line) at 1:100. The cells were fixed in 4% formaldehyde (15min) and permeated by 0.2% TritonX-100 for 10min. Then 10% normal goat serum to block non-specific protein-protein interactions followed by the antibody (1ug/1*106cells) for 45min at 4℃. The secondary antibody used was FITC-conjugated Goat Anti-Rabbit IgG(H+L) at 1/200 dilution for 35 min at 4°C. Isotype control antibody (green line) was mouse IgG1 (1μg/1*106cells) used under the same conditions. Acquisition of >10,000 events was performed.
Human Receptor tyrosine-protein kinase erbB-3(ERBB3) ELISA kit (CSB-EL007765HU)
驗證數(shù)據(jù)
貨號：CSB-EL007765HU
規(guī)格：96T/48T
靈敏度：31.25 pg/mL
檢測范圍：125 pg/mL-8000 pg/mL
These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
ERBB3 Antibodies
ERBB3 for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 種屬反應性 | 應用類型 |
|---|---|---|---|
| CSB-PA007765GA01HU | ERBB3 Antibody | Human,Mouse,Rat | ELISA,IHC |
| CSB-PA007765ESR1HU | ERBB3 Antibody | Human | ELISA, IHC |
| CSB-PA824036 | Phospho-ERBB3 (Tyr1328) Antibody | Human,Mouse,Rat | ELISA,WB,IHC,IF |
| CSB-PA926047 | ERBB3 (Ab-1289) Antibody | Human | ELISA,IF |
| CSB-PA787403 | ERBB3 (Ab-1328) Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-PA259090 | ERBB3 Antibody | Human | ELISA,WB,IHC |
| CSB-PA002395 | ERBB3 Antibody | Human,Mouse,Rat | WB, IHC, ELISA |
| CSB-PA002404 | ERBB3 Antibody | Human,Mouse,Rat | WB, IHC, IF, ELISA |
| CSB-PA002405 | ERBB3 Antibody | Human,Mouse,Rat | WB, IHC, IF, ELISA |
| CSB-PA008093 | Phospho-ERBB3 (Y1197) Antibody | Human,Mouse,Rat | WB, ELISA |
| CSB-PA008094 | Phospho-ERBB3 (Y1222) Antibody | Human,Mouse,Rat | WB, IHC, IF, ELISA |
| CSB-PA008098 | Phospho-ERBB3 (Y1328) Antibody | Human,Mouse,Rat | IHC, ELISA |
| CSB-PA008102 | Phospho-ERBB3 (Y1289) Antibody | Human,Mouse,Rat | WB, IHC, IF, ELISA |
| CSB-PA008105 | ERBB3 Antibody | Human,Mouse,Rat | WB, ELISA |
| CSB-PA008110 | ERBB3 Antibody | Human | WB, IHC, ELISA |
| CSB-PA325213 | ERBB3 Antibody | Human,Mouse,Rat | ELISA,IHC |
| CSB-PA578770 | ERBB3 Antibody | Human,Mouse,Rat | ELISA,IHC |
| CSB-RA937008A0HU | ERBB3 Recombinant Monoclonal Antibody | Human | ELISA, IF |
ERBB3 Proteins
ERBB3 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP007765HU CSB-EP007765HU CSB-BP007765HU CSB-EP007765HU-B |
Recombinant Human Receptor tyrosine-protein kinase erbB-3 (ERBB3), partial | Yeast E.coli Baculovirus In Vivo Biotinylation in E.coli |
| CSB-MP007765HU | Recombinant Human Receptor tyrosine-protein kinase erbB-3 (ERBB3), partial (Active) | Mammalian cell |
ERBB3 Proteins for Rattus norvegicus (Rat)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP717284RA CSB-EP717284RA CSB-BP717284RA CSB-MP717284RA CSB-EP717284RA-B |
Recombinant Rat Receptor tyrosine-protein kinase erbB-3 (Erbb3), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
ERBB3 Proteins for Pongo abelii (Sumatran orangutan)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP722389PYX CSB-EP722389PYX CSB-BP722389PYX CSB-MP722389PYX CSB-EP722389PYX-B |
Recombinant Pongo abelii Receptor tyrosine-protein kinase erbB-3 (ERBB3), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
ERBB3 Proteins for Mus musculus (Mouse)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP736823MO CSB-EP736823MO CSB-BP736823MO CSB-MP736823MO CSB-EP736823MO-B |
Recombinant Mouse Receptor tyrosine-protein kinase erbB-3 (Erbb3), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
ERBB3 ELISA Kit
ERBB3 ELISA Kit for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-EL007765HU | Human Receptor tyrosine-protein kinase erbB-3(ERBB3) ELISA kit | serum, plasma, tissue homogenates | 31.25 pg/mL |
