ITGAL
ITGAL對應的蛋白全稱為整合素αL，也被稱為CD11a或LFA-1α，常與β2亞基結合形成淋巴細胞功能相關抗原-1（LFA-1）。這種蛋白在免疫細胞表面廣泛表達，尤其在T細胞和中性粒細胞中活躍，通過介導細胞間黏附參與炎癥反應、免疫細胞遷移及抗原提呈等過程。其功能異常常與自身免疫疾病相關，例如多發(fā)性硬化癥、類風濕性關節(jié)炎患者的LFA-1活性異常升高，導致免疫細胞過度攻擊自身組織。此外，該蛋白在器官移植排斥反應和某些白血病中也顯示出調控作用。
近年來，針對LFA-1的抑制劑成為藥物開發(fā)熱點。早期單抗藥物如奧法木單抗曾用于治療復發(fā)型多發(fā)性硬化，但因療效局限逐漸淡出。小分子拮抗劑如BMS-817399在動物模型中顯示出抑制炎癥浸潤潛力，目前處于臨床前研究階段。部分藥物因阻斷LFA-1可能引發(fā)感染風險，研究者正探索局部給藥或變構調節(jié)策略以平衡療效與安全性。在腫瘤免疫領域，聯(lián)合LFA-1調控與其他免疫檢查點抑制劑的方案也進入早期探索。
熱銷產品
Recombinant Human Integrin alpha-L (ITGAL), partial (CSB-MP011875HU)
驗證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
The purity of ITGAL was greater than 90% as determined by SEC-HPLC
ITGAL Recombinant Monoclonal Antibody (CSB-RA787996A0HU)
驗證數(shù)據(jù)
Western Blot
Positive WB detected in: THP-1 whole cell lysate
All lanes: ITGAL antibody at 1:2000
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 129, 135, 120 kDa
Observed band size: 130 kDa
Immunofluorescence staining of THP-1 cell with CSB-RA787996A0HU at 1:50, counter-stained with DAPI. The cells were fixed in 4% formaldehyde and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 490-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
ITGAL Antibodies
ITGAL for Mus musculus (Mouse)
| 產品貨號 | 產品名稱 | 種屬反應性 | 應用類型 |
|---|---|---|---|
| CSB-PA011875LA01MO | Itgal Antibody | Mouse | ELISA |
ITGAL for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 種屬反應性 | 應用類型 |
|---|---|---|---|
| CSB-PA006157 | ITGAL Antibody | Human | WB, ELISA |
| CSB-PA932598 | ITGAL Antibody | Human | ELISA,IHC |
| CSB-PA011875LA01HU | ITGAL Antibody | Human | ELISA, WB, IHC, IF |
| CSB-PA011875LB01HU | ITGAL Antibody, HRP conjugated | Human | ELISA |
| CSB-RA787996A0HU | ITGAL Recombinant Monoclonal Antibody | Human | ELISA, WB, IF |
ITGAL Proteins
ITGAL Proteins for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-BP011875HU CSB-EP011875HU-B |
Recombinant Human Integrin alpha-L (ITGAL), partial | Baculovirus In Vivo Biotinylation in E.coli |
| CSB-EP011875HU | Recombinant Human Integrin alpha-L (ITGAL), partial | E.coli |
| CSB-YP011875HU | Recombinant Human Integrin alpha-L (ITGAL), partial | Yeast |
| CSB-MP011875HU | Recombinant Human Integrin alpha-L (ITGAL), partial | Mammalian cell |
ITGAL Proteins for Mus musculus (Mouse)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP011875MO | Recombinant Mouse Integrin alpha-L (Itgal), partial | Yeast |
| CSB-EP011875MO | Recombinant Mouse Integrin alpha-L (Itgal), partial | E.coli |
| CSB-BP011875MO CSB-MP011875MO CSB-EP011875MO-B |
Recombinant Mouse Integrin alpha-L (Itgal), partial | Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
ITGAL Proteins for Bos taurus (Bovine)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP011875BO CSB-EP011875BO CSB-BP011875BO CSB-MP011875BO CSB-EP011875BO-B |
Recombinant Bovine Integrin alpha-L (ITGAL), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
