TSHR
TSHR，即促甲狀腺激素受體，別名Thyrotropinreceptor。它是一種細胞表面糖蛋白受體，屬于A類G蛋白偶聯受體（GPCRs）超家族的LGR亞家族，并與Gs蛋白相連接。TSHR主要在甲狀腺組織中表達，但其mRNA和蛋白也存在于神經組織、免疫細胞、眼肌、骨骼、脂肪細胞、紅細胞、卵巢和肝臟等部位。TSHR的作用機制是通過其受體感知由垂體細胞分泌的促甲狀腺激素（TSH）信號，啟動偶聯信號通路，促進下游效應基因的表達，刺激細胞生成甲狀腺激素（T4）和三碘甲狀腺激素（T3），對甲狀腺的生長和功能至關重要。TSHR的異常激活或失調與多種疾病有關，如Graves病（GD）患者產生自身抗體激活TSHR，導致甲亢，并可能發展為Graves眼病（GO），引起眼部肌肉腫脹。TSHR功能失調也會影響甲狀腺激素生成，引發甲減。橋本病（Hashimoto'sdisease）患者產生抑制TSHR的抗體，可導致甲狀腺功能減退。TSHR的表達在某些甲狀腺結節和癌癥中的變化可以作為診斷和預后的指標。
熱銷產品
Recombinant Human Thyrotropin receptor (TSHR)-VLPs (Active) (CSB-MP025131HU)
驗證數據
CSB-MP025131HU is detected by Mouse anti-6*His monoclonal antibody.
Activity
Measured by its binding ability in a functional ELISA. Immobilized Human TSHR at 10 μg/ml can bind Anti-TSHR recombinant antibody (CSB-RA025131MA1HU). The EC50 is 30.81-36.12 ng/mL.The VLPs (CSB-MP3838) is negative control.
The purity of VLPs was greater than 90% as determined by SEC-HPLC
TSHR Recombinant Monoclonal Antibody (CSB-RA025131MA1HU)
驗證數據
The Binding Activity of Human TSHR with Anti-TSHR Recombinant Antibody
Activity: Measured by its binding ability in a functional ELISA. Immobilized Human TSHR (CSB-MP025131HU) at 10 μg/mL can bind Anti-TSHR recombinant antibody. The EC50 is 30.81-36.12 ng/mL.The VLPs (CSB-MP3838) is negative control.
Untransfected HEK293T cells (green line) and transfected Human TSHR HEK293T stable cells (red line) were stained with anti-TSHR antibody (CSB-RA025131MA1HU) (2μg/1*106cells), washed and then followed by APC-conjugated anti-Human IgG Fc antibody and analyzed with flow cytometry.
The purity of TSHR was greater than 95% as determined by SEC-HPLC
TSHR Antibodies
TSHR for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 種屬反應性 | 應用類型 |
|---|---|---|---|
| CSB-PA11189D0Rb | TSHR Antibody, Biotin conjugated | Human | ELISA |
| CSB-PA11189C0Rb | TSHR Antibody, FITC conjugated | Human | |
| CSB-PA11189B0Rb | TSHR Antibody, HRP conjugated | Human | ELISA |
| CSB-PA11189A0Rb | TSHR Antibody | Human | ELISA, IF |
| CSB-PA025131GA01HU | TSHR Antibody | Human,Mouse | ELISA,WB |
| CSB-PA973863 | TSHR Antibody | Human | ELISA,IHC |
| CSB-PA820027 | TSHR Antibody | Human | ELISA,IHC |
| CSB-RA025131MA1HU | TSHR Recombinant Monoclonal Antibody | Human | ELISA |
TSHR Proteins
TSHR Proteins for Canis familiaris (Dog) (Canis lupus familiaris)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP025131DO1 CSB-EP025131DO1 CSB-BP025131DO1 CSB-MP025131DO1 CSB-EP025131DO1-B |
Recombinant Dog Thyrotropin receptor (TSHR), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF025131DO | Recombinant Dog Thyrotropin receptor (TSHR) | in vitro E.coli expression system |
TSHR Proteins for Rattus norvegicus (Rat)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP025131RA1 CSB-EP025131RA1 CSB-BP025131RA1 CSB-MP025131RA1 CSB-EP025131RA1-B |
Recombinant Rat Thyrotropin receptor (Tshr), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF025131RA | Recombinant Rat Thyrotropin receptor (Tshr) | in vitro E.coli expression system |
TSHR Proteins for Mus musculus (Mouse)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP025131MO CSB-EP025131MO CSB-EP025131MO-B |
Recombinant Mouse Thyrotropin receptor (Tshr), partial | Yeast E.coli In Vivo Biotinylation in E.coli |
| CSB-BP025131MO | Recombinant Mouse Thyrotropin receptor (Tshr), partial | Baculovirus |
| CSB-MP025131MO | Recombinant Mouse Thyrotropin receptor (Tshr), partial | Mammalian cell |
TSHR Proteins for Ovis aries (Sheep)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP025131SH1 CSB-EP025131SH1 CSB-BP025131SH1 CSB-MP025131SH1 CSB-EP025131SH1-B |
Recombinant Sheep Thyrotropin receptor (TSHR), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF025131SH | Recombinant Sheep Thyrotropin receptor (TSHR) | in vitro E.coli expression system |
TSHR Proteins for Bos taurus (Bovine)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP631684BO1 CSB-EP631684BO1 CSB-BP631684BO1 CSB-MP631684BO1 CSB-EP631684BO1-B |
Recombinant Bovine Thyrotropin receptor (TSHR), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF631684BO | Recombinant Bovine Thyrotropin receptor (TSHR) | in vitro E.coli expression system |
TSHR Proteins for Sus scrofa (Pig)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP819360PI CSB-EP819360PI CSB-BP819360PI CSB-MP819360PI CSB-EP819360PI-B |
Recombinant Pig Thyrotropin receptor (TSHR), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
TSHR Proteins for Felis catus (Cat) (Felis silvestris catus)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP858993CA1 CSB-EP858993CA1 CSB-BP858993CA1 CSB-MP858993CA1 CSB-EP858993CA1-B |
Recombinant Cat Thyrotropin receptor (TSHR), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF858993CA | Recombinant Cat Thyrotropin receptor (TSHR) | in vitro E.coli expression system |
TSHR Proteins for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-BP025131HU1 | Recombinant Human Thyrotropin receptor (TSHR), partial | Baculovirus |
| CSB-MP025131HU | Recombinant Human Thyrotropin receptor (TSHR)-VLPs (Active) | Mammalian cell |
