DLK1
DLK1，即Delta/Notch樣蛋白激酶1，別名包括Delta1、Notch1LT、ZNR4、p68、Dlk1/FA1。它是一種由DLK1基因編碼的跨膜蛋白，屬于Delta/Notch信號通路的成員，在多種組織中表達。DLK1的作用機制涉及與Notch受體的相互作用，通過非經典Notch信號通路參與細胞命運決定和細胞增殖的調控。DLK1參與了多種生理過程，包括胚胎發育、細胞分化、組織再生和代謝調控。DLK1的功能異常與多種疾病有關，如代謝綜合征、神經退行性疾病和癌癥。研究表明，DLK1在調節脂肪細胞分化和胰島素敏感性中發揮作用，其在腫瘤細胞中的異常表達可能與腫瘤的增殖和轉移能力增強有關。
熱銷產品
Recombinant Human Protein delta homolog 1 (DLK1), partial (CSB-EP006945HU)
驗證數據
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
DLK1 Antibody (CSB-PA006945LA01HU)
驗證數據
Western Blot
Positive WB detected in: A549 whole cell lysate, MCF-7 whole cell lysate, HepG2 whole cell lysate, SH-SY5Y whole cell lysate, Rat brain tissue
All lanes: DLK1 antibody at 4.6µg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 42, 34 kDa
Observed band size: 42 kDa
IHC image of CSB-PA006945LA01HU diluted at 1:300 and staining in paraffin-embedded human pancreatic tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
Immunofluorescence staining of HepG2 cells with CSB-PA006945LA01HU at 1:100, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
DLK1 Antibodies
DLK1 for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 種屬反應性 | 應用類型 |
|---|---|---|---|
| CSB-PA006945GA01HU | DLK1 Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-PA006945LA01HU | DLK1 Antibody | Human, Rat | ELISA, WB, IHC, IF |
| CSB-PA824488 | DLK1 Antibody | Human | ELISA,WB |
| CSB-PA120648 | DLK1 Antibody | Human,Mouse | ELISA,WB |
DLK1 Proteins
DLK1 Proteins for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP006945HU | Recombinant Human Protein delta homolog 1 (DLK1), partial | Yeast |
| CSB-EP006945HU | Recombinant Human Protein delta homolog 1 (DLK1), partial | E.coli |
| CSB-MP006945HU | Recombinant Human Protein delta homolog 1 (DLK1), partial | Mammalian cell |
| CSB-BP006945HU CSB-EP006945HU-B |
Recombinant Human Protein delta homolog 1 (DLK1), partial | Baculovirus In Vivo Biotinylation in E.coli |
DLK1 ELISA Kit
DLK1 ELISA Kit for Mus musculus (Mouse)
| 產品貨號 | 產品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-EL006945MO | Mouse Protein delta homolog 1(DLK1) ELISA kit | serum, plasma, tissue homogenates | 3.9 pg/mL |
