
類風濕性關節炎(Rheumatoid Arthritis, RA)是一種慢性、進行性自身免疫性疾病,主要累及外周關節,以對稱性多關節炎為核心特征,可伴隨關節軟骨和骨破壞、關節畸形,甚至累及心、肺、血管等全身多系統。其發病機制復雜,涉及遺傳(如HLA-DRB1等易感基因)、環境(吸煙、感染)及免疫異常:自身反應性T細胞活化后,誘導B細胞產生類風濕因子(RF)和抗環瓜氨酸肽抗體(抗CCP),同時滑膜成纖維細胞異常增殖并分泌大量促炎細胞因子(如TNF-α、IL-6、IL-17)及基質金屬蛋白酶(MMPs),最終引發關節炎癥和骨侵蝕。臨床表現為晨僵(>30分鐘)、對稱性關節腫痛(手、腕、足小關節為主)、類風濕結節,晚期可出現關節畸形(如天鵝頸畸形)及功能喪失。
近年來,RA藥物研發聚焦于精準靶向免疫異常通路,突破傳統治療局限(如甲氨蝶呤療效不足或生物制劑耐藥):
- IL-23/IL-17軸靶向藥物成為熱點:IL-23通過激活Th17細胞促進IL-17分泌,后者直接誘導關節炎癥。2023年,禮來(Eli Lilly)的mirikizumab(抗IL-23p19單抗)在RA III期試驗中顯示,對甲氨蝶呤應答不佳患者,聯合治療后ACR50顯著優于安慰劑;諾華的secukinumab(抗IL-17A單抗)雖在銀屑病中表現突出,其在RA的擴展研究(如MEASURE 2)顯示,對TNF抑制劑耐藥患者仍有30%-40%的ACR20應答,提示IL-17靶向在特定亞組中有效。
- 新型JAK抑制劑優化了療效與安全性:選擇性JAK1抑制劑烏帕替尼(upadacitinib)于2022年獲FDA批準,其對JAK1的選擇性高于JAK2/3,較非選擇性JAK抑制劑(如托法替布)降低貧血等血液學副作用風險,III期數據顯示,單藥或聯合甲氨蝶呤治療12周時,ACR50應答率達48%(vs 安慰劑28%)。
- 補體系統靶向藥物嶄露頭角:補體過度激活(尤其C5a-C5aR1通路)可招募中性粒細胞并加劇滑膜炎癥。ChemoCentryx公司的avacopan(抗C5aR1抑制劑)在ANCA相關血管炎中已獲批,其RA II期試驗(CCX140-202)顯示,聯合甲氨蝶呤治療24周時,DAS28-CRP(疾病活動度評分)改善優于安慰劑,目前進入III期驗證。
此外,表觀遺傳調控藥物(如HDAC抑制劑)和B細胞共刺激阻斷劑(如抗CD40L)仍處于早期研發階段,但為RA個體化治療提供了新方向。總體而言,RA藥物正從“廣譜抗炎”向“精準靶向”升級,未來或可通過生物標志物(如IL-23水平、JAK磷酸化狀態)實現更精準的患者分層與治療選擇。
類風濕性關節炎在研藥物靶點
- ADAMTS4
- AOC3
- BSG
- C5AR1
- CANX
- CCL2
- CD19
- CD2
- CD22
- CD28
- CD4
- CD40
- CD40LG
- CD6
- CD69
- CD7
- CDH11
- CEL
- CFP
- CLEC4C
- COL2A1
- CSF1
- CSF1R
- CSF2
- CSF2RA
- CSF3R
- CX3CL1
- CXCL10
- CXCL13
- CXCL8
- CXCR2
- ENO1
- FAS
- FCER2
- FCGRT
- FLT3LG
- H2A
- ICAM1
- ICOSLG
- IFNA2
- IFNAR1
- IFNG
- IL12B
- IL15
- IL17A
- IL17F
- IL17RA
- IL18
- IL1A
- IL1B
- IL1R1
- IL20
- IL21
- IL22
- IL23A
- IL6
- IL7R
- ITGA11
- ITGA2
- ITGA4
- ITGA9
- ITGAL
- KLRC1
- KLRK1
- KNG1
- LAG3
- LILRA4
- LYVE1
- MCL1
- MMP9
- MOSPD2
- MS4A1
- OSM
- PADI4
- PDCD1
- PTPRC
- SPP1
- TLR4
- TNFRSF13C
- TNFRSF17
- TNFRSF1A
- TNFRSF4
- TNFSF
- TNFSF11
- TNFSF12
- TNFSF13
- TNFSF13B
- TNFSF15
- TR
- VIM
類風濕性關節炎藥物靶點相關產品推薦
● 靶點蛋白
CSB-MP003996HU

Measured by its binding ability in a functional ELISA. Immobilized human C5AR1 at 10 μg/ml can bind Anti-C5AR1 recombinant antibody (CSB-RA003996A0HU), the EC50 is 1.239-3.760 ng/mL.
CSB-MP004900HU

Measured by its binding ability in a functional ELISA. Immobilized CD22 at 2 μg/ml can bind Anti-CD22 rabbit monoclonal antibody, the EC50 of human CD22 protein is 4.034-4.800 ng/ml.
CSB-MP004952HU

Measured by its binding ability in a functional ELISA. Immobilized Human CD69 at 2μg/mL can bind Anti-CD69 recombinant antibody (CSB-RA004952MA1HU), the EC50 is 23.17-26.04 ng/mL.
CSB-MP855470HUh7

Measured by its binding ability in a functional ELISA. Immobilized Human CLEC4C at 2μg/mL can bind Anti-CLEC4C recombinant antibody(CSB-RA855470MA1HU),the EC50 is 7.658-12.99 ng/mL.
CSB-MP006043HU1

The ED50 as determined by the dose-dependent stimulation of the proliferation of THP-1 cells is 2.880-4.115 ng/mL.
CSB-MP006045HU

The ED50 as determined by the dose-dependent stimulation of the proliferation of human TF-1 cells is 28.1-63.8 pg/mL.
CSB-MP010958HU1

Measured by its binding ability in a functional ELISA. Immobilized ICOSLG at 2 μg/ml can bind human ICOS (CSB-MP707478HU), the EC50 of human ICOSLG protein is 29.04-43.59 ng/ml.
CSB-MP360706HU

Measured by its binding ability in a functional ELISA. Immobilized Human IFNA2 at 2 μg/ml can bind Human IFNAR2(CSB-MP011047HU). The EC50 is 154.2-191.9 ng/mL.
Target | Product Name | Source | Tag Info | Code |
---|---|---|---|---|
ADAMTS4 | Recombinant Human A disintegrin and metalloproteinase with thrombospondin motifs 4 (ADAMTS4), partial | E.coli | N-terminal GST-tagged | CSB-EP001311HU1 |
BSG | Rcombinant Human Basigin (BSG), partial | E.coli | N-terminal 6xHis-tagged | CSB-RP117574h |
BSG | Recombinant Human Basigin (BSG), partial (Active) | Mammalian cell | C-terminal hFc1-tagged | CSB-MP002831HU1 |
C5AR1 | Recombinant Human C5a anaphylatoxin chemotactic receptor (C5AR1) | in vitro E.coli expression system | C-terminal 10xHis-tagged | CSB-CF003996HUd7 |
C5AR1 | Recombinant Human C5a anaphylatoxin chemotactic receptor 1 (C5AR1)-VLPs (Active) | Mammalian cell | C-terminal 10xHis-tagged (This tag can be tested only under denaturing conditions) | CSB-MP003996HU |
C5AR1 | Recombinant Human C5a anaphylatoxin chemotactic receptor (C5AR1), partial | E.coli | N-terminal 6xHis-KSI-tagged | CSB-EP003996HU1 |
C5AR1 | Recombinant Human C5a anaphylatoxin chemotactic receptor (C5AR1), partial, Biotinylated | E.coli | N-terminal MBP-tagged and C-terminal 6xHis-Avi-tagged | CSB-EP003996HU1-B |
C5ar1 | Recombinant Mouse C5a anaphylatoxin chemotactic receptor (C5ar1), partial | E.coli | N-terminal 6xHis-KSI-tagged | CSB-EP003996MO1 |
C5ar1 | Recombinant Mouse C5a anaphylatoxin chemotactic receptor (C5ar1), partial, Biotinylated | E.coli | N-terminal MBP-tagged and C-terminal 6xHis-Avi-tagged | CSB-EP003996MO1-B |
C5ar1 | Recombinant Mouse C5a anaphylatoxin chemotactic receptor 1 (C5ar1)-VLPs | Mammalian cell | C-terminal 10xHis-tagged | CSB-MP003996MO |
C5AR1 | Recombinant Macaca fascicularis C5a anaphylatoxin chemotactic?receptor 1(C5AR1)-VLPs | Mammalian cell | C-terminal 10xHis-tagged | CSB-MP003996MOW |
CCL2 | Recombinant Human C-C motif chemokine 2 (CCL2) | E.coli | N-terminal GST-tagged | CSB-EP004783HU |
CCL2 | Recombinant Human C-C motif chemokine 2 (CCL2) | E.coli | N-terminal 10xHis-tagged and C-terminal Myc-tagged | CSB-EP004783HUb1 |
CCL2 | Recombinant Mouse C-C motif chemokine 2 (Ccl2), partial | E.coli | N-terminal 6xHis-tagged | CSB-EP004783MO |
CD19 | Recombinant Human B-lymphocyte antigen CD19 (CD19), partial | in vitro E.coli expression system | N-terminal 6xHis-tagged | CSB-CF004888HU |
CD19 | Recombinant Human B-lymphocyte antigen CD19 (CD19), partial | in vitro E.coli expression system | C-terminal 6xHis-tagged | CSB-CF004888HUc7 |
CD19 | Recombinant Human B-lymphocyte antigen CD19 (CD19), partial | Mammalian cell | N-terminal 10xHis-tagged and C-terminal Myc-tagged | CSB-MP004888HU |
CD19 | Recombinant Human B-lymphocyte antigen CD19 (CD19), partial (Active) | Mammalian cell | C-terminal Fc-tagged | CSB-AP005061HU |
CD19 | Recombinant Human B-lymphocyte antigen CD19 (CD19), partial, Biotinylated | Mammalian cell | C-terminal hFc1-Avi-tagged | CSB-MP004888HU-B |
CD2 | Recombinant Human T-cell surface antigen CD2 (CD2), partial | E.coli | N-terminal 6xHis-SUMO-tagged | CSB-EP004894HU |
● 抗體
CSB-RA780821A0HU

Tested Applications:
ELISA, WB, IHC, IP
CSB-RA004935A0HU

Tested Applications:
ELISA, WB, IHC
CSB-RA252392A0HU

Tested Applications:
ELISA, WB, IHC
CSB-RA010949MA1HU

Tested Applications:
ELISA, WB, IHC, FC
CSB-RA012936MA1HU

Tested Applications:
ELISA, WB, IHC
CSB-RA787996A0HU

Tested Applications:
ELISA, WB, IF
CSB-RA014679A0HU

Tested Applications:
ELISA, IHC, FC
CSB-RA011614MA1HU

Tested Applications:
ELISA, IHC, FC
- 重組抗體
Target | Product Name | Species Reactivity | Tested Applications | Code |
---|---|---|---|---|
AOC3 | AOC3 Recombinant Monoclonal Antibody | Human | ELISA, IHC | CSB-RA624122MA1HU |
C5AR1 | C5AR1 Recombinant Monoclonal Antibody | Human | ELISA | CSB-RA003996A0HU |
CCL2 | CCL2 Recombinant Monoclonal Antibody | Human | ELISA, IHC | CSB-RA004783MA1HU |
CD19 | CD19 Recombinant Monoclonal Antibody | Human | ELISA | CSB-RA004888A0HU |
CD19 | CD19 Recombinant Monoclonal Antibody | Human | ELISA, WB, IHC, IP | CSB-RA780821A0HU |
CD19 | CD19 Recombinant Monoclonal Antibody | Human | ELISA, WB | CSB-RA004888MA1HU |
CD19 | CD19 Recombinant Monoclonal Antibody | Human | ELISA, IF | CSB-RA004888MA2HU |
CD22 | CD22 Recombinant Monoclonal Antibody | Human | ELISA, IHC | CSB-RA962691A0HU |
CD4 | CD4 Recombinant Monoclonal Antibody | Human | ELISA, WB, IHC | CSB-RA004935A0HU |
CD40 | CD40 Recombinant Monoclonal Antibody | Human | ELISA, IF, FC | CSB-RA004936MA1HU |
CD69 | CD69 Recombinant Monoclonal Antibody | Human | ELISA | CSB-RA004952MA1HU |
CDH11 | CDH11 Recombinant Monoclonal Antibody | Human | ELISA, IF | CSB-RA005036MA1HU |
CLEC4C | CLEC4C Recombinant Monoclonal Antibody | Human | ELISA | CSB-RA855470MA1HU |
CSF3R | CSF3R Recombinant Monoclonal Antibody | Human | ELISA, IHC | CSB-RA860321MA1HU |
CXCL10 | CXCL10 Recombinant Monoclonal Antibody | Human | ELISA, IHC | CSB-RA903061A0HU |
FAS | FAS Recombinant Monoclonal Antibody | Human | ELISA, WB, IHC | CSB-RA252392A0HU |
FCGRT | FCGRT Recombinant Monoclonal Antibody | Human | ELISA, IHC | CSB-RA008545MA1HU |
ICAM1 | ICAM1 Recombinant Monoclonal Antibody | Human | ELISA, IHC, FC | CSB-RA162789A0HU |
ICAM1 | ICAM1 Recombinant Monoclonal Antibody | Human | ELISA, WB, IHC, FC | CSB-RA010949MA1HU |
IFNA2 | IFNA2 Recombinant Monoclonal Antibody | Human | ELISA | CSB-RA365593MA1MO |
- 單克隆抗體
Target | Product Name | Species Reactivity | Tested Applications | Code |
---|---|---|---|---|
CANX | CANX Monoclonal Antibody | Human | ELISA, WB, FC | CSB-MA004485A0m |
CANX | CANX Monoclonal Antibody | Human | ELISA, WB, IF, FC | CSB-MA004485A1m |
CCL2 | CCL2 Monoclonal Antibody | Human | ELISA, IHC | CSB-MA058641A0m |
CD19 | CD19 Monoclonal Antibody | Human | ELISA, WB, IHC, IF, FC | CSB-MA004888A0m |
CD19 | CD19 Monoclonal Antibody | Human | ELISA, WB, IHC, FC | CSB-MA004888A1m |
CD19 | CD19 Monoclonal Antibody,APC Conjugated | Human | ELISA, IF, FC | CSB-MA195220 |
CD19 | CD19 Monoclonal Antibody,Biotin Conjugated | Human | ELISA, IF, FC | CSB-MA899608 |
CD19 | CD19 Monoclonal Antibody,FITC Conjugated | Human | ELISA, IF, FC | CSB-MA047662 |
CD19 | CD19 Monoclonal Antibody,PE Conjugated | Human | ELISA, IF, FC | CSB-MA036486 |
CD19 | CD19 Monoclonal Antibody,PE-Cy5 Conjugated | Human | ELISA, IF, FC | CSB-MA281869 |
CD19 | CD19 Monoclonal Antibody,Purified | Human | ELISA, FC | CSB-MA798261 |
CD2 | CD2 Monoclonal Antibody | Human,Mouse,Rat | ELISA, IHC | CSB-MA000227 |
CD2 | CD2 Monoclonal Antibody,FITC Conjugated | Human | ELISA, IF, FC | CSB-MA785710 |
CD4 | CD4 Monoclonal Antibody | Human,Mouse,Rat | ELISA, IHC | CSB-MA000228 |
CD4 | CD4 Monoclonal Antibody,APC Conjugated | Human | ELISA, IF, FC | CSB-MA043428 |
CD4 | CD4 Monoclonal Antibody,Biotin Conjugated | Human | ELISA, IF, FC | CSB-MA981329 |
CD4 | CD4 Monoclonal Antibody,FITC Conjugated | Human | ELISA, IF, FC | CSB-MA124048 |
CD4 | CD4 Monoclonal Antibody,PE Conjugated | Human | ELISA, IF, FC | CSB-MA260243 |
CD4 | CD4 Monoclonal Antibody,PE-Cy5 Conjugated | Human | ELISA, IF, FC | CSB-MA570802 |
CD4 | CD4 Monoclonal Antibody,Purified | Human | ELISA, FC | CSB-MA783233 |
- 多克隆抗體
Target | Product Name | Species Reactivity | Tested Applications | Code |
---|---|---|---|---|
AOC3 | AOC3 Antibody | Human | ELISA, IHC, IF | CSB-PA624122LA01HU |
AOC3 | AOC3 Antibody, HRP conjugated | Human | ELISA | CSB-PA624122LB01HU |
AOC3 | AOC3 Antibody, FITC conjugated | Human | CSB-PA624122LC01HU | |
AOC3 | AOC3 Antibody, Biotin conjugated | Human | ELISA | CSB-PA624122LD01HU |
AOC3 | AOC3 Antibody | Human, Mouse, Rat | ELISA, WB | CSB-PA001855GA01HU |
BSG | BSG Antibody | Human | ELISA, WB, IHC | CSB-PA11759A0Rb |
BSG | BSG Antibody, HRP conjugated | Human | ELISA | CSB-PA11759B0Rb |
BSG | BSG Antibody, FITC conjugated | Human | CSB-PA11759C0Rb | |
BSG | BSG Antibody, Biotin conjugated | Human | ELISA | CSB-PA11759D0Rb |
BSG | BSG Antibody | Human | ELISA, WB | CSB-PA005853 |
BSG | BSG Antibody | Human, Mouse, Rat | ELISA, WB, IHC | CSB-PA002331 |
BSG | BSG Antibody | Human | ELISA, WB, IHC | CSB-PA002831GA01HU |
BSG | BSG Antibody | Human | ELISA, IHC | CSB-PA993569 |
BSG | BSG Antibody | Human | ELISA, WB, IHC | CSB-PA570608 |
C5AR1 | C5AR1 Antibody | Human | ELISA, WB, IF | CSB-PA003996LA01HU |
C5AR1 | C5AR1 Antibody, HRP conjugated | Human | ELISA | CSB-PA003996LB01HU |
C5AR1 | C5AR1 Antibody, FITC conjugated | Human | CSB-PA003996LC01HU | |
C5AR1 | C5AR1 Antibody, Biotin conjugated | Human | ELISA | CSB-PA003996LD01HU |
C5AR1 | C5AR1 Antibody | Human | ELISA, WB, IHC, IF | CSB-PA001479 |
C5AR1 | Phospho-C5AR1 (S338) Antibody | Human | ELISA, IHC | CSB-PA060025 |
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● ELISA試劑盒

Human
Interleukin 8,IL-8 ELISA KIT
CSB-E04641h

Mouse
Interferon γ,IFN-γ ELISA Kit
CSB-E04578m

Mouse
Interleukin 17,IL-17 ELISA Kit
CSB-E04608m

Human
Interleukin 1β,IL-1β ELISA Kit
CSB-E08053h
Target | Product Name | Sample Types | Detection Range | Code |
---|---|---|---|---|
ADAMTS4 | 人ADAM金屬肽酶含血小板反應蛋白1基元4(ADAMTS4)酶聯免疫試劑盒 | serum, plasma, tissue homogenates | 12.5 ng/ml - 800 ng/ml | CSB-E11848h |
ADAMTS4 | 小鼠金屬肽酶含血小板反應蛋白4(ADAMTS4)酶聯免疫試劑盒 | serum, plasma, tissue homogenates | 3.12 ng/mL-200 ng/ mL | CSB-EL001311MO |
AOC3 | 小鼠伯胺氧化酶膜(AOC3)酶聯免疫試劑盒 | serum, plasma, tissue homogenates | 1.25 ng/mL-80 ng/mL | CSB-EL001855MO |
AOC3 | 大鼠伯胺氧化酶膜(AOC3)酶聯免疫試劑盒 | serum, plasma, tissue homogenates | 7.8 ng/mL-500 ng/mL | CSB-EL001855RA |
BSG | 人CD147分子(CD147)酶聯免疫試劑盒 | serum, plasma | 12.5 pg/mL-800 pg/mL | CSB-E12994h |
CCL2 | 人單核細胞趨化蛋白1(MCP-1/CCL2/MCAF)酶聯免疫試劑盒 | serum, plasma, urine, saliva, cerebrospinal fluid (CSF), ascitic fluid, cell culture supernates, tis | 6.25 pg/ml-400 pg/ml. | CSB-E04655h |
CCL2 | 小鼠單核細胞趨化蛋白1(MCP-1/CCL2/MCAF)酶聯免疫試劑盒 | serum, plasma, tissue homogenates | 78 pg/mL-5000 pg/mL | CSB-E07430m |
CCL2 | 犬單核細胞趨化蛋白1(MCP-1/CCL2/MCAF)酶聯免疫試劑盒 | serum, plasma, tissue homogenates | 0.125 ng/mL-8 ng/mL | CSB-E15747c |
CCL2 | 大鼠單核細胞趨化蛋白1(MCP-1/CCL2/MCAF)酶聯免疫試劑盒 | serum, plasma, cell culture supernates, tissue homogenates | 3.9 pg/mL-250 pg/mL | CSB-E07429r-IS |
CCL2 | 豬單核細胞趨化蛋白1(MCP-1/CCL2/MCAF)酶聯免疫試劑盒 | serum, plasma | 31.25 pg/mL-2000 pg/mL | CSB-E13178p |
CCL2 | 兔子單核細胞趨化蛋白1(MCP-1/CCL2/MCAF)酶聯免疫試劑盒 | serum, plasma, tissue homogenates | 23.5 pg/mL-1500 pg/mL | CSB-E06921Rb |
CCL2 | 大鼠單核細胞趨化蛋白1(MCP-1/CCL2/MCAF)酶聯免疫試劑盒 | serum, plasma, tissue homogenates | 31.25 pg/mL-2000 pg/mL | CSB-E07429r |
CCL2 | 牛單核細胞趨化蛋白1(MCP-1/CCL2/MCAF)酶聯免疫試劑盒 | serum, plasma, tissue homogenates | 78 pg/mL-5000 pg/mL | CSB-E16221B |
CCL2 | 豚鼠單核細胞趨化蛋白1(MCP-1/CCL2/MCAF)酶聯免疫試劑盒 | serum, plasma, tissue homogenates | 23.5 pg/mL-1500 pg/mL | CSB-E13559Gp |
CCL2 | 猴子單核細胞趨化蛋白1(MCP-1/CCL2/MCAF)酶聯免疫試劑盒 | serum, plasma, tissue homogenates | 62.5 pg/mL-4000 pg/mL | CSB-E10045Mo |
CD28 | 人可溶性CD28(sCD28)酶聯免疫試劑盒 | serum, plasma, tissue homogenates | 0.625 ng/mL-40 ng/mL | CSB-E09296h |
CD4 | 大鼠CD4分子(CD4)酶聯免疫試劑盒 | serum, plasma, tissue homogenates | 0.78 U/mL-50 U/mL | CSB-E12928r |
CD4 | 雞CD4分子(CD4)酶聯免疫試劑盒 | serum, plasma, tissue homogenates | 3.125 ng/mL-800 ng/mL | CSB-E13114C |
CD4 | 人CD4分子(CD4)酶聯免疫試劑盒 | serum, plasma | 0.625 ng/mL-40 ng/mL | CSB-E08956h |
CD40 | 小鼠腫瘤壞死因子受體超家族成員5(CD40)酶聯免疫試劑盒 | serum, plasma, tissue homogenates | 31.2 pg/ml - 2000 pg/ml | CSB-EL004936MO |