SPP1
SPP1蛋白全稱分泌磷蛋白1，又稱骨橋蛋白或OPN，是一種多功能糖蛋白，廣泛存在于骨骼、免疫細胞及腫瘤微環境中。SPP1通過與整合素受體結合，參與調控細胞黏附、遷移及礦化過程，在骨折修復和血管鈣化中具有雙重調節作用。SPP1異常高表達與乳腺癌、肝癌等實體瘤轉移密切相關，同時與多發性硬化癥、動脈粥樣硬化等慢性炎癥性疾病進程存在顯著關聯。在骨質疏松患者中，血清SPP1水平可作為骨質流失的動態監測指標。
針對SPP1的治療策略主要采用單克隆抗體中和其病理功能。人源化抗體KPL-404在類風濕性關節炎Ⅱ期試驗中表現出抑制關節破壞的潛力，而siRNA藥物STP705通過局部注射降低瘢痕疙瘩中SPP1表達量，已完成皮膚纖維化治療的Ⅰ期安全性驗證。某些天然多酚化合物被發現能阻斷SPP1與CD44受體的相互作用，這為開發口服小分子抑制劑提供了新方向，但其生物利用度仍是當前研究瓶頸。
熱銷產品
Recombinant Human Osteopontin (SPP1) (CSB-MP022603HU(F5))
驗證數據
-SDS.jpg)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
SPP1 Recombinant Monoclonal Antibody (CSB-RA022603MA1HU)
驗證數據
Overlay Peak curve showing A549 cells stained with CSB-RA022603MA1HU (red line) at 1:100. Then 10% normal goat serum was Incubated to block non-specific protein-protein interactions followed by the antibody (1μg/1*106cells) for 45 min at 4°C. The secondary antibody used was FITC-conjugated Goat Anti-Mouse IgG(H+L) at 1/200 dilution for 35 min at 4°C. Isotype control antibody (green line) was mouse IgG1 (1μg/1*106cells) used under the same conditions. Acquisition of >10, 000 events was performed.
SPP1 Antibodies
SPP1 for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 種屬反應性 | 應用類型 |
|---|---|---|---|
| CSB-PA06904A0Rb | SPP1 Antibody | Human | ELISA, IHC |
| CSB-PA06904C0Rb | SPP1 Antibody, FITC conjugated | Human | |
| CSB-PA06904D0Rb | SPP1 Antibody, Biotin conjugated | Human | ELISA |
| CSB-PA06904B0Rb | SPP1 Antibody, HRP conjugated | Human | ELISA |
| CSB-PA827743 | SPP1 Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-PA003599 | SPP1 Antibody | Human,Mouse,Rat | WB, IHC, ELISA |
| CSB-PA297038 | SPP1 Antibody | Human | ELISA,WB,IHC |
| CSB-PA264573 | SPP1 Antibody | Human,Mouse | ELISA,WB |
| CSB-RA261140A0HU | SPP1 Recombinant Monoclonal Antibody | Human | ELISA, WB, IHC |
| CSB-RA022603MA1HU | SPP1 Recombinant Monoclonal Antibody | Human | ELISA, FC |
SPP1 for Mus musculus (Mouse)
| 產品貨號 | 產品名稱 | 種屬反應性 | 應用類型 |
|---|---|---|---|
| CSB-PA022603YD01MO | Spp1 Antibody, Biotin conjugated | Mouse | ELISA |
| CSB-PA022603YA01MO | Spp1 Antibody | Mouse | ELISA, WB |
SPP1 Proteins
SPP1 Proteins for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP022603HU(F5) | Recombinant Human Osteopontin (SPP1) | Yeast |
| CSB-YP021198HU CSB-EP021198HU CSB-BP021198HU CSB-MP021198HU CSB-EP021198HU-B |
Recombinant Human Sphingosine-1-phosphate phosphatase 1 (SGPP1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-MP022603HU(F5) | Recombinant Human Osteopontin (SPP1) | Mammalian cell |
SPP1 Proteins for Mus musculus (Mouse)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP022603MO | Recombinant Mouse Osteopontin (Spp1), partial | Yeast |
| CSB-BP022603MO CSB-MP022603MO CSB-EP022603MO-B |
Recombinant Mouse Osteopontin (Spp1), partial | Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
SPP1 Proteins for Sus scrofa (Pig)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP022603PI CSB-EP022603PI CSB-BP022603PI CSB-MP022603PI CSB-EP022603PI-B |
Recombinant Pig Osteopontin (SPP1) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
SPP1 Proteins for Bos taurus (Bovine)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP022603BO CSB-EP022603BO CSB-BP022603BO CSB-MP022603BO CSB-EP022603BO-B |
Recombinant Bovine Osteopontin (SPP1) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
SPP1 Proteins for Gallus gallus (Chicken)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP022603CH CSB-EP022603CH CSB-BP022603CH CSB-MP022603CH CSB-EP022603CH-B |
Recombinant Chicken Osteopontin (SPP1) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
SPP1 Proteins for Oryctolagus cuniculus (Rabbit)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP022603RB CSB-EP022603RB CSB-BP022603RB CSB-MP022603RB CSB-EP022603RB-B |
Recombinant Rabbit Osteopontin (SPP1) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
SPP1 Proteins for Rattus norvegicus (Rat)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP022603RA CSB-EP022603RA CSB-BP022603RA CSB-MP022603RA CSB-EP022603RA-B |
Recombinant Rat Osteopontin (Spp1) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
SPP1 Proteins for Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP527933SXV CSB-EP527933SXV CSB-BP527933SXV CSB-MP527933SXV CSB-EP527933SXV-B |
Recombinant Schizosaccharomyces pombe Set1 complex component spp1 (spp1) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
SPP1 Proteins for Nicotiana tabacum (Common tobacco)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP708413NHE CSB-EP708413NHE CSB-BP708413NHE CSB-MP708413NHE CSB-EP708413NHE-B |
Recombinant Nicotiana tabacum Sucrose-phosphatase 1 (SPP1) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
SPP1 Proteins for Oryza sativa subsp. japonica (Rice)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP842478OFG CSB-EP842478OFG CSB-BP842478OFG CSB-MP842478OFG CSB-EP842478OFG-B |
Recombinant Oryza sativa subsp. japonica Probable sucrose-phosphatase 1 (SPP1) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
SPP1 Proteins for Arabidopsis thaliana (Mouse-ear cress)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP863231DOA CSB-EP863231DOA CSB-BP863231DOA CSB-MP863231DOA CSB-EP863231DOA-B |
Recombinant Arabidopsis thaliana Probable sucrose-phosphatase 1 (SPP1) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
SPP1 Proteins for Zea mays (Maize)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP884318ZAX CSB-EP884318ZAX CSB-BP884318ZAX CSB-MP884318ZAX CSB-EP884318ZAX-B |
Recombinant Zea mays Sucrose-phosphatase 1 (SPP1) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
SPP1 Proteins for Ovis aries (Sheep)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP893170SH CSB-EP893170SH CSB-BP893170SH CSB-MP893170SH CSB-EP893170SH-B |
Recombinant Sheep Osteopontin (SPP1) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
SPP1 ELISA Kit
SPP1 ELISA Kit for Mus musculus (Mouse)
| 產品貨號 | 產品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-E12008m | Mouse Osteopontin（OPN）ELISA Kit | serum, plasma, cell culture supernates, tissue homogenates. | 19.5 pg/ml. |
SPP1 ELISA Kit for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-E08392h | Human Osteopontin,OPN ELISA Kit | serum, plasma, urine, tissue homogenates | 0.195 ng/mL |
SPP1 ELISA Kit for Rattus norvegicus (Rat)
| 產品貨號 | 產品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-E08393r | Rat Osteopontin,OPN ELISA Kit | serum, plasma, tissue homogenates | 0.06 ng/ml |
