LILRA4 Recombinant Monoclonal Antibody

說明書

中文名稱：

LILRA4 Recombinant Monoclonal Antibody
貨號：

CSB-RA012936MA1HU
規格：

￥1320
圖片：
Western Blot Positive WB detected in:Hela whole cell lysate (20μg), HpeG2 whole cell lysate (20μg), Jurkat whole cell lysate (20μg), K562 whole cell lysate (20μg) All lanes: LILRA4 antibody at 1:1000 Secondary Goat polyclonal to human IgG at 1/40000 dilution Predicted band size:55.18, 47.81 kDa Observed band size:50 kDa Exposure time:20s

IHC image of CSB-RA012936MA1HU diluted at 1:100 and staining in paraffin-embedded human skin tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-human polymer IgG labeled by HRP and visualized using 0.05% DAB.
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

產品描述：

CSB-RA012936MA1HU LILRA4重組單克隆抗體是針對人白細胞免疫球蛋白樣受體A4（LILRA4）開發的高特異性科研工具。該抗體采用重組技術制備，可精準識別LILRA4蛋白，該靶標作為免疫調節受體家族成員，在髓系細胞中特異性表達，參與調控天然免疫應答及炎癥反應，與自身免疫性疾病、病毒感染等病理過程密切相關。經嚴格驗證，本產品在Western Blot實驗中可識別重組表達及天然LILRA4蛋白，在1:500-1:2000稀釋范圍內呈現清晰的特異性條帶；免疫組化應用顯示其在1:50-1:200濃度下能有效定位石蠟包埋組織中LILRA4的細胞膜/胞質分布，同時適用于ELISA檢測體系。該抗體具備優異的批間一致性，適用于探索LILRA4在免疫細胞功能調控、疾病相關信號通路及腫瘤微環境中的作用機制，為免疫學研究、炎癥性疾病模型構建及靶向治療策略開發提供可靠試劑支持，建議配合同源重組蛋白用于實驗體系驗證。
Uniprot No.：

P59901
基因名：

LILRA4
別名：

CD85 antigen-like family member G antibody; CD85g antibody; ILT-7 antibody; ILT7 antibody; Immunoglobulin like transcript 7 antibody; Immunoglobulin-like transcript 7 antibody; Leukocyte immunoglobulin-like receptor subfamily A member 4 antibody; LILRA4 antibody; LIRA4_HUMAN antibody; MGC129597 antibody; MGC129598 antibody
反應種屬：

Human
免疫原：

Recombinant Human LILRA4 protein
免疫原種屬：

Homo sapiens (Human)
標記方式：

Non-conjugated
克隆類型：

Monoclonal
抗體亞型：

hIgG1
純化方式：

Affinity-chromatography
克隆號：

24F6
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA, WB, IHC

推薦稀釋比：

Application	Recommended Dilution
WB	1:500-1:2000
IHC	1:50-1:200

Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
Immunohistochemistry (IHC) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Functions coreceptor to limit the innate immune responses to viral infections; signaling occurs via FCER1G. Down-regulates the production of IFNA1, IFNA2, IFNA4, IFNB1 and TNF by plasmacytoid dendritic cells that have been exposed to influenza virus or cytidine-phosphate-guanosine (CpG) dinucleotides, indicating it functions as negative regulator of TLR7 and TLR9 signaling cascades. Down-regulates interferon production in response to interaction with BST2 on HIV-1 infected cells. Activates a signaling cascade in complex with FCER1G that results in phosphorylation of Src family and Syk kinases and thereby triggers mobilization of intracellular Ca(2+). Does not interfere with the differentiation of plasmacytoid dendritic cells into antigen-presenting cells.
基因功能參考文獻：
1. Crosslinked ILT7 favours the differentiation of immature plasmacytoid dendritic cells into antigen-presenting cells rather than IPC. PMID: 24586760
2. ILT7 may exert its immunomodulatory activity only on immature circulating plasmacytoid dendritic cells (pDCs), providing a basic homeostatic mechanism rather than negative feedback control on activated pDCs. PMID: 23401591
3. Intracellular expression of the TCL1 as well as membrane and intracellular expression of ILT7 in plasmacytoid dendritic cell leukemia (pDCL) samples and 61 non-pDC acute leukemia samples, were tested. PMID: 22674796
4. the expression of immunoglobulin-like transcript 7, in plasmacytoid dendritic cells PMID: 12384430
5. ILT7 protein associates with the signal adapter protein Fc epsilonRI gamma to form a receptor complex in dendritic cells. PMID: 16735691
6. key regulator of human pDC function and interferon type I production. PMID: 18048391
7. Data show that BST2 directly binds to purified ILT7, initiates signaling via the ILT7-FcepsilonRIgamma complex, and regulates TLR7/9 responses in plasmacytoid dendritic cells. PMID: 19564354
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亞細胞定位：

Cell membrane; Single-pass type I membrane protein.
組織特異性：

Detected on plasmacytoid dendritic cells (at protein level). Detected on plasmacytoid dendritic cells, but not on monocytes or B cells.
數據庫鏈接：

HGNC: 15503

OMIM: 607517

KEGG: hsa:23547

STRING: 9606.ENSP00000291759

UniGene: Hs.406708

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