ICOSLG
ICOSLG（Inducible T-cell COStimulator Ligand），也稱為B7-H2或CD275，是一種免疫檢查點(diǎn)分子跨膜蛋白，通常由抗原呈遞細(xì)胞（如抗原呈遞的樹突狀細(xì)胞）和B細(xì)胞表達(dá)。其分子結(jié)構(gòu)包括一個Ig-like V型結(jié)構(gòu)域，用于與其受體ICOS結(jié)合，以及跨膜區(qū)域和細(xì)胞內(nèi)結(jié)構(gòu)域。ICOSLG與其受體ICOS之間的相互作用在免疫系統(tǒng)中具有關(guān)鍵作用。當(dāng)ICOSLG與ICOS結(jié)合時，它促進(jìn)T細(xì)胞的激活和增殖，以及B細(xì)胞的抗體產(chǎn)生。這對于調(diào)節(jié)免疫應(yīng)答和維持免疫平衡至關(guān)重要。ICOSLG的活化還可以影響調(diào)節(jié)性T細(xì)胞的生成，對免疫耐受性和自身免疫疾病的控制有重要影響。在癌癥治療中，抑制ICOSLG-ICOS相互作用可能有助于增強(qiáng)T細(xì)胞免疫反應(yīng)，對抗腫瘤。此外，ICOSLG的拮抗劑（抑制劑）被研究用于自身免疫疾病的治療，因為它們可以減少異常的免疫活性。是癌癥免疫治療和自身免疫疾病治療的重要靶點(diǎn)。
熱銷產(chǎn)品
Recombinant Human ICOS ligand(ICOSLG),partial (Active) CSB-MP010958HU1
驗證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Activity: Measured by its binding ability in a functional ELISA. Immobilized ICOSLG at 2 μg/ml can bind human ICOS (CSB-MP707478HU), the EC50 of human ICOSLG protein is 29.04-43.59 ng/ml.
ICOSLG Antibodies
ICOSLG for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA010958GA01HU | ICOSLG Antibody | Human | ELISA,WB |
| CSB-PA010958ESR1HU | ICOSLG Antibody | Human | ELISA, IHC |
| CSB-PA279895 | ICOSLG Antibody | Human | ELISA,IHC |
| CSB-PA924853 | ICOSLG Antibody | Human | ELISA,WB |
ICOSLG Proteins
ICOSLG Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP010958HU1 CSB-EP010958HU1 CSB-BP010958HU1 CSB-EP010958HU1-B |
Recombinant Human ICOS ligand (ICOSLG), partial | Yeast E.coli Baculovirus In Vivo Biotinylation in E.coli |
| CSB-CF010958HU | Recombinant Human ICOS ligand (ICOSLG) | in vitro E.coli expression system |
| CSB-MP010958HU1 | Recombinant Human ICOS ligand (ICOSLG), partial (Active) | Mammalian cell |
| CSB-MP010958HU1-B | Recombinant Human ICOS ligand (ICOSLG), partial, Biotinylated | Mammalian cell |
ICOSLG ELISA Kit
ICOSLG ELISA Kit for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-EL010958HU | Human ICOS ligand(ICOSLG) ELISA kit | serum, plasma, tissue homogenates | 23.4 pg/mL |
