TNFSF12
TNFSF12全稱為腫瘤壞死因子超家族成員12，常被稱為TWEAK或APO3L。這一蛋白廣泛表達(dá)于免疫細(xì)胞中，通過與細(xì)胞表面受體FN14結(jié)合，觸發(fā)炎癥反應(yīng)、細(xì)胞增殖或凋亡，并參與調(diào)控組織修復(fù)、血管生成及免疫調(diào)節(jié)等過程。研究發(fā)現(xiàn)，其在慢性炎癥性疾病中異常活躍，例如系統(tǒng)性紅斑狼瘡、類風(fēng)濕性關(guān)節(jié)炎患者體內(nèi)TWEAK水平顯著升高。此外，TNFSF12與腫瘤微環(huán)境密切相關(guān)，可促進(jìn)某些癌癥的侵襲轉(zhuǎn)移，同時與神經(jīng)退行性疾病如多發(fā)性硬化、阿爾茨海默病的病理進(jìn)展存在關(guān)聯(lián)。
近年來，針對TWEAK-FN14軸的治療策略成為研究熱點(diǎn)。例如，單克隆抗體類藥物通過阻斷兩者結(jié)合，已在動物模型中顯示出抑制腫瘤生長和減輕炎癥損傷的效果。部分小分子抑制劑也進(jìn)入臨床前研究階段，嘗試用于治療自身免疫性疾病和纖維化病癥。其在心血管疾病中的作用存在爭議，既有研究提示可能加重動脈粥樣硬化，也有證據(jù)表明適度表達(dá)可促進(jìn)血管再生，這種雙重特性使藥物研發(fā)需精準(zhǔn)把控干預(yù)時機(jī)與劑量。
熱銷產(chǎn)品
驗(yàn)證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
TNFSF12 Antibody (CSB-PA023987ESR1HU)
驗(yàn)證數(shù)據(jù)
Immunohistochemistry of paraffin-embedded human prostate tissue using CSB-PA023987ESR1HU at dilution of 1:100
Immunohistochemistry of paraffin-embedded human epityphlon tissue using CSB-PA023987ESR1HU at dilution of 1:100
TNFSF12 Antibodies
TNFSF12 for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA023987GA01HU | TNFSF12 Antibody | Human,Mouse,Rat | ELISA |
| CSB-PA023987ESR1HU | TNFSF12 Antibody | Human | ELISA, IHC |
| CSB-PA152148 | TNFSF12 Antibody | Human,Mouse | ELISA,WB,IHC,IF |
| CSB-PA004351 | TNFSF12 Antibody | Human,Mouse | WB, IHC, IF, ELISA |
| CSB-PA023987LA01HU | TNFSF12 Antibody | Human | ELISA, IHC, IF |
| CSB-PA023987LD01HU | TNFSF12 Antibody, Biotin conjugated | Human | ELISA |
TNFSF12 Proteins
TNFSF12 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP023987HU CSB-BP023987HU CSB-MP023987HU CSB-EP023987HU-B |
Recombinant Human Tumor necrosis factor ligand superfamily member 12 (TNFSF12), partial | Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF023987HU(A4) | Recombinant Human Tumor necrosis factor ligand superfamily member 12 (TNFSF12) | in vitro E.coli expression system |
| CSB-EP023987HU | Recombinant Human Tumor necrosis factor ligand superfamily member 12 (TNFSF12), partial | E.coli |
TNFSF12 ELISA Kit
TNFSF12 ELISA Kit for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-E16492h | Human soluble tumor necrosis factor-like weak inducer of apoptosis (sTWEAK)ELISA Kit | serum, plasma, tissue homogenates | 0.078 ng/ml |
