CD6
CD6是一種關(guān)鍵的1型跨膜糖蛋白，其細(xì)胞外部分包含三個(gè)富含半胱氨酸的清道夫受體結(jié)構(gòu)域，高度糖基化，并與免疫球蛋白超家族分子CD166（ALCAM）作為其主要配體相互作用。當(dāng)CD6與ALCAM結(jié)合時(shí)，會(huì)激活與T細(xì)胞活化、增殖、分化和存活相關(guān)的絲裂原活化蛋白激酶通路。這一相互作用在維持免疫平衡、調(diào)節(jié)T細(xì)胞功能及轉(zhuǎn)運(yùn)中起到重要作用。研究表明，通過(guò)阻斷CD6-ALCAM通路，可以抑制致病性T細(xì)胞的激活和轉(zhuǎn)運(yùn)，為相關(guān)疾病的治療提供了新的策略。此外，CD6還涉及胸腺細(xì)胞與基質(zhì)細(xì)胞的相互作用以及自身免疫和移植物抗宿主病等過(guò)程。
熱銷(xiāo)產(chǎn)品
驗(yàn)證數(shù)據(jù)
All lanes: CD6 antibody at 4μg/ml
Lane 1: Hela whole cell lysate
Lane 2: Jurkat whole cell lysate
Lane 3: HT-29 whole cell lysate
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 72, 69, 64, 65, 59, 61 kDa
Observed band size: 72 kDa
Immunohistochemistry of paraffin-embedded human tonsil tissue using CSB-PA326953ESR1HU at dilution of 1:100
Immunohistochemistry of paraffin-embedded human thymus tissue using CSB-PA326953ESR1HU at dilution of 1:100
CD6 Antibodies
CD6 for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱(chēng) | 種屬反應(yīng)性 | 應(yīng)用類(lèi)型 |
|---|---|---|---|
| CSB-PA134350 | CD6 Antibody | Human | ELISA,WB |
| CSB-PA326953ESR1HU | CD6 Antibody | Human | ELISA, WB, IHC |
| CSB-PA326953ESR2HU | CD6 Antibody | Human | ELISA, IHC |
| CSB-PA006156 | CD6 Antibody | Human | WB, ELISA |
| CSB-PA070265 | CD6 Antibody | Human | WB, ELISA |
CD6 Proteins
CD6 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱(chēng) | 來(lái)源 |
|---|---|---|
| CSB-YP326953HU1 CSB-EP326953HU1 CSB-BP326953HU1 CSB-MP326953HU1 CSB-EP326953HU1-B |
Recombinant Human T-cell differentiation antigen CD6 (CD6), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
