CLEC4C Recombinant Monoclonal Antibody
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中文名稱(chēng)：CLEC4C重組抗體
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貨號(hào)：CSB-RA855470MA1HU
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規(guī)格：￥1320
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圖片：
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The Binding Activity of CLEC4C with anti-CLEC4C antibody
Activity: Measured by its binding ability in a functional ELISA. Immobilized Human CLEC4C (CSB-MP855470HUh7) at 2 μg/mL can bind Anti-CLEC4C recombinant antibody，the EC50 is 7.658-12.99 ng/mL.
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其他：
產(chǎn)品詳情
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產(chǎn)品描述：CSB-RA855470MA1HU是針對(duì)CLEC4C靶點(diǎn)開(kāi)發(fā)的重組單克隆抗體，該靶點(diǎn)又稱(chēng)CD303或BDCA-2，屬于C型凝集素受體家族成員，主要在漿細(xì)胞樣樹(shù)突狀細(xì)胞（pDC）表面特異性表達(dá)，通過(guò)識(shí)別病原體相關(guān)分子模式參與先天免疫應(yīng)答，并在調(diào)控I型干擾素分泌、抗病毒免疫及自身免疫性疾病發(fā)生中發(fā)揮關(guān)鍵作用。本抗體通過(guò)ELISA驗(yàn)證，展現(xiàn)出高特異性和靈敏度，可有效識(shí)別天然及重組表達(dá)的CLEC4C蛋白，適用于體外研究該分子在免疫調(diào)節(jié)中的功能機(jī)制。其應(yīng)用場(chǎng)景包括探索病毒感染中pDC的激活途徑、自身免疫性疾病（如系統(tǒng)性紅斑狼瘡）的分子機(jī)制，以及腫瘤微環(huán)境中免疫細(xì)胞相互作用的研究，為解析CLEC4C介導(dǎo)的信號(hào)通路、開(kāi)發(fā)相關(guān)免疫調(diào)控策略提供可靠工具。本產(chǎn)品適用于基礎(chǔ)科研領(lǐng)域，包括但不限于蛋白質(zhì)互作分析、細(xì)胞功能研究及體外分子檢測(cè)等實(shí)驗(yàn)體系。
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Uniprot No.：
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基因名：
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別名：C-type lectin domain family 4 member C (Blood dendritic cell antigen 2) (BDCA-2) (C-type lectin superfamily member 7) (Dendritic lectin) (CD antigen CD303), CLEC4C, BDCA2 CLECSF11 CLECSF7 DLEC HECL
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反應(yīng)種屬：Human
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免疫原：Recombinant Human CLEC4C protein
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免疫原種屬：Homo sapiens (Human)
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標(biāo)記方式：Non-conjugated
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克隆類(lèi)型：Monoclonal
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抗體亞型：hIgG1
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純化方式：Affinity-chromatography
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克隆號(hào)：7B8
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 -
產(chǎn)品提供形式：Liquid
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應(yīng)用范圍：ELISA
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Protocols：
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儲(chǔ)存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產(chǎn)品評(píng)價(jià)
相關(guān)產(chǎn)品
靶點(diǎn)詳情
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功能：Lectin-type cell surface receptor which may play a role in antigen capturing by dendritic cells. Specifically recognizes non-sialylated galactose-terminated biantennary glycans containing the trisaccharide epitope Gal(beta1-3/4)GlcNAc(beta1-2)Man. Binds to serum IgG. Efficiently targets ligand into antigen-processing and peptide-loading compartments for presentation to T-cells. May mediate potent inhibition of induction of IFN-alpha/beta expression in plasmacytoid dendritic cells. May act as a signaling receptor that activates protein-tyrosine kinases and mobilizes intracellular calcium.
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基因功能參考文獻(xiàn)：
- Identification of serum glycoprotein ligands for the immunomodulatory receptor blood dendritic cell antigen 2. PMID: 29796630
- decrease in the surface expression of CLEC4C and the endoplasmic reticulum localization of the mutant construct were observed PMID: 26943047
- Human BDCA2+CD123+CD56+ dendritic cells (DCs) related to blastic plasmacytoid dendritic cell neoplasm represent a unique myeloid DC subset. PMID: 25779340
- BDCA-2 binds selectively to glycans containing the epitope Galbeta1-3/4GlcNAcbeta1-2Man. PMID: 25995448
- We show the crystal structures of a carbohydrate recognition domain (CRD) of human C-type lectin receptor blood dendritic cell antigen-2 (BDCA2). PMID: 24425442
- Reduction in Treg numbers following Ag delivery to BDCA2 restored both CD4(+) T cell activation and Ab responses, demonstrating that Tregs were required for the observed tolerance. PMID: 24829416
- Data show that HCV envelope glycoprotein E2 is a novel ligand of blood dendritic cells antigen 2 (BDCA-2). PMID: 23053572
- Human C-type lectin domain family 4, member C (CLEC4C/BDCA-2/CD303) is a receptor for asialo-galactosyl-oligosaccharides. PMID: 21880719
- Accumulation of BDCA-1 and BDCA-2 around neovessels showed that mDCs and pDCs are recruited to advanced arteriosclerotic plaques. PMID: 21436634
- Expression of dendritic cell markers CD11c/BDCA-1 and CD123/BDCA-2 in coronary artery disease upon activation in whole blood. PMID: 20888334
- Indoleamine 2,3-deoxigenase positive plasmacytoid dentritic cells are the classical BDCA2 positive cells in melanoma lymph nodes PMID: 19829303
- Data suggest that by associating with Fc epsilon RI gamma, BDCA2 activates a novel BCR-like signaling pathway to regulate the immune functions of plasmacytoid dendritic cells. PMID: 17850179
- Triggering CD303 leads to tyrosine phosphorylation of Syk, Slp65, PLCgamma2 and cytoskeletal proteins. CD303 signaling is linked with internalization by clathrin-mediated endocytosis. PMID: 18022864
- results suggest that downregulation of BDCA2 expression on plasmacytoid dendritic cells (pDCs) may reflect the activation of pDCs accumulated in systemic lupus erythematosus patients & may be one marker for indication of disease activity of SLE patients PMID: 18684674
- Engagement of BDCA-2 blocks TRAIL-mediated cytotoxic activity of plasmacytoid dendritic cells. PMID: 19577819
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亞細(xì)胞定位：Cell membrane; Single-pass type II membrane protein.
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組織特異性：Expressed in plasmacytoid dendritic cells (PDCs). Constitutively expressed in immature monocyte-derived dendritic cells (iMDDC) and is significantly down-regulated upon maturation with LPS but not with TNF-alpha.
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