MCL1
MCL1，即髓樣細(xì)胞白血病1蛋白，別名MCL-1。MCL1是一種抗凋亡蛋白，屬于Bcl-2家族成員，主要通過(guò)與促凋亡Bcl-2蛋白結(jié)合來(lái)防止細(xì)胞凋亡。MCL1在多種細(xì)胞類(lèi)型中表達(dá)，尤其在造血干細(xì)胞和神經(jīng)細(xì)胞中發(fā)揮重要作用。MCL1的作用機(jī)制涉及其在細(xì)胞內(nèi)線(xiàn)粒體膜上的定位，通過(guò)其BH3結(jié)合位點(diǎn)與其他Bcl-2家族成員相互作用，調(diào)節(jié)細(xì)胞生存和凋亡。在細(xì)胞應(yīng)激時(shí)，MCL1的表達(dá)和穩(wěn)定性發(fā)生變化，從而影響細(xì)胞命運(yùn)。MCL1還參與調(diào)節(jié)細(xì)胞周期、DNA損傷響應(yīng)、自噬、線(xiàn)粒體動(dòng)力學(xué)和能量代謝等非凋亡過(guò)程。MCL1的表達(dá)失調(diào)與多種疾病的發(fā)生發(fā)展有關(guān)，尤其是在癌癥中，MCL1的過(guò)表達(dá)與腫瘤的發(fā)生、不良預(yù)后和耐藥性密切相關(guān)。
熱銷(xiāo)產(chǎn)品
驗(yàn)證數(shù)據(jù)
Western Blot analysis of HepG2 cells using Mcl-1 Polyclonal Antibody
Western Blot analysis of NIH-3T3 Jurkat cells using Mcl-1 Polyclonal Antibody
MCL1 Antibodies
MCL1 for Mus musculus (Mouse)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱(chēng) | 種屬反應(yīng)性 | 應(yīng)用類(lèi)型 |
|---|---|---|---|
| CSB-PA013588HD01MO | Mcl1 Antibody, Biotin conjugated | Mouse | ELISA |
| CSB-PA013588HA01MO | Mcl1 Antibody | Mouse | ELISA |
MCL1 for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱(chēng) | 種屬反應(yīng)性 | 應(yīng)用類(lèi)型 |
|---|---|---|---|
| CSB-PA013588GA01HU | MCL1 Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-PA274877 | MCL1 Antibody | Human | ELISA,WB |
| CSB-PA787977 | MCL1 Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-PA003207 | MCL1 Antibody | Human,Mouse,Rat | WB, IHC, ELISA |
| CSB-PA004991 | MCL1 Antibody | Human,Mouse,Rat | WB, ELISA |
| CSB-PA010105 | Phospho-MCL1 (S159) Antibody | Human,Mouse | WB, IF, ELISA |
| CSB-PA010107 | MCL1 Antibody | Human,Mouse,Monkey | WB, ELISA |
| CSB-PA256752 | MCL1 Antibody | Human,Mouse,Rat | ELISA,IHC |
| CSB-PA438059 | MCL1 Antibody | Human,Mouse,Rat | ELISA,IHC |
| CSB-PA03829A0Rb | MCL1 Antibody | Human | ELISA, WB, IHC, IF |
| CSB-PA03829B0Rb | MCL1 Antibody, HRP conjugated | Human | ELISA |
| CSB-PA03829C0Rb | MCL1 Antibody, FITC conjugated | Human | |
| CSB-PA03829D0Rb | MCL1 Antibody, Biotin conjugated | Human | ELISA |
MCL1 Proteins
MCL1 Proteins for Mus musculus (Mouse)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱(chēng) | 來(lái)源 |
|---|---|---|
| CSB-YP013588MO CSB-BP013588MO CSB-MP013588MO CSB-EP013588MO-B |
Recombinant Mouse Induced myeloid leukemia cell differentiation protein Mcl-1 homolog (Mcl1), partial | Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-EP013588MO | Recombinant Mouse Induced myeloid leukemia cell differentiation protein Mcl-1 homolog (Mcl1), partial | E.coli |
| CSB-CF013588MO | Recombinant Mouse Induced myeloid leukemia cell differentiation protein Mcl-1 homolog (Mcl1) | in vitro E.coli expression system |
MCL1 Proteins for Rhodobacter sphaeroides (strain ATCC 17029 / ATH 2.4.9)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱(chēng) | 來(lái)源 |
|---|---|---|
| CSB-YP385863RIJ CSB-EP385863RIJ CSB-BP385863RIJ CSB-MP385863RIJ CSB-EP385863RIJ-B |
Recombinant Rhodobacter sphaeroides Malyl-CoA lyase (mcl1) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
MCL1 Proteins for Rhodobacter sphaeroides (strain ATCC 17025 / ATH 2.4.3)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱(chēng) | 來(lái)源 |
|---|---|---|
| CSB-YP394443RLG CSB-EP394443RLG CSB-BP394443RLG CSB-MP394443RLG CSB-EP394443RLG-B |
Recombinant Rhodobacter sphaeroides Malyl-CoA lyase (mcl1) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
MCL1 Proteins for Rhodobacter capsulatus (Rhodopseudomonas capsulata)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱(chēng) | 來(lái)源 |
|---|---|---|
| CSB-YP466974RLC CSB-EP466974RLC CSB-BP466974RLC CSB-MP466974RLC CSB-EP466974RLC-B |
Recombinant Rhodobacter capsulatus Malyl-CoA lyase (mcl1) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
MCL1 Proteins for Rhodobacter sphaeroides (strain KD131 / KCTC 12085)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱(chēng) | 來(lái)源 |
|---|---|---|
| CSB-YP495428RLH CSB-EP495428RLH CSB-BP495428RLH CSB-MP495428RLH CSB-EP495428RLH-B |
Recombinant Rhodobacter sphaeroides Malyl-CoA lyase (mcl1) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
MCL1 Proteins for Rhodobacter capsulatus (strain ATCC BAA-309 / NBRC 16581 / SB1003)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱(chēng) | 來(lái)源 |
|---|---|---|
| CSB-YP522144RLD CSB-EP522144RLD CSB-BP522144RLD CSB-MP522144RLD CSB-EP522144RLD-B |
Recombinant Rhodobacter capsulatus Malyl-CoA lyase (mcl1) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
MCL1 Proteins for Rhodobacter sphaeroides (strain ATCC 17023 / 2.4.1 / NCIB 8253 / DSM 158)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱(chēng) | 來(lái)源 |
|---|---|---|
| CSB-YP667039RLF CSB-EP667039RLF CSB-BP667039RLF CSB-MP667039RLF CSB-EP667039RLF-B |
Recombinant Rhodobacter sphaeroides Malyl-CoA lyase (mcl1) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
MCL1 Proteins for Felis catus (Cat) (Felis silvestris catus)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱(chēng) | 來(lái)源 |
|---|---|---|
| CSB-YP768742CA1 CSB-EP768742CA1 CSB-BP768742CA1 CSB-MP768742CA1 CSB-EP768742CA1-B |
Recombinant Cat Induced myeloid leukemia cell differentiation protein Mcl-1 homolog (MCL1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF768742CA | Recombinant Cat Induced myeloid leukemia cell differentiation protein Mcl-1 homolog (MCL1) | in vitro E.coli expression system |
MCL1 Proteins for Canis familiaris (Dog) (Canis lupus familiaris)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱(chēng) | 來(lái)源 |
|---|---|---|
| CSB-YP810233DO1 CSB-EP810233DO1 CSB-BP810233DO1 CSB-MP810233DO1 CSB-EP810233DO1-B |
Recombinant Dog Induced myeloid leukemia cell differentiation protein Mcl-1 homolog (MCL1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF810233DO | Recombinant Dog Induced myeloid leukemia cell differentiation protein Mcl-1 homolog (MCL1) | in vitro E.coli expression system |
MCL1 Proteins for Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱(chēng) | 來(lái)源 |
|---|---|---|
| CSB-YP874875SXV CSB-EP874875SXV CSB-BP874875SXV CSB-MP874875SXV CSB-EP874875SXV-B |
Recombinant Schizosaccharomyces pombe Minichromosome loss protein 1 (mcl1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
