P4HA2
P4HA2，即脯氨酰4-羥化酶亞基2，別名包括 2-oxoglutarate-4-dioxygenase subunit alpha-2、4 PH alpha 2、4-PH alpha-2、C-P4Halpha(II)。它是一種由P4HA2基因編碼的蛋白質，屬于脯氨酰4-羥化酶的α亞基，是膠原蛋白合成的關鍵酶之一。P4HA2的作用機制主要是催化膠原蛋白前體鏈中脯氨酸殘基的4-羥化，這一過程對于膠原蛋白的正確三螺旋結構形成至關重要。P4HA2參與了細胞外基質的重塑，影響腫瘤細胞的極性、運動和信號轉導。P4HA2的表達與多種實體腫瘤的侵襲、轉移密切相關，并且可以調控腫瘤相關基因表達、增強腫瘤細胞惡性表型表達及耐藥性形成。在腫瘤微環境中，P4HA2通過促進膠原蛋白沉積與硬化重塑腫瘤微環境，進而促進腫瘤進展。此外，P4HA2還通過調節細胞代謝、促進腫瘤起始細胞存活、參與血管基底膜生成及調控腫瘤相關基因表達等多種作用機制促進腫瘤細胞增殖、黏附和轉移。
熱銷產品
P4HA2 Antibody (CSB-PA017340ESR2HU)
驗證數據
Immunohistochemistry of paraffin-embedded human breast cancer using CSB-PA017340ESR2HU at dilution of 1:100
Immunohistochemistry of paraffin-embedded human placenta tissue using CSB-PA017340ESR2HU at dilution of 1:100
Immunoprecipitating P4HA2 in Hela whole cell lysate
Lane 1: Rabbit control IgG instead of (1μg) instead of CSB-PA017340ESR2HU in Hela whole cell lysate.
For western blotting, a HRP-conjugated anti-rabbit IgG, specific to the non-reduced form of IgG was used as the Secondary antibody (1/50000)
Lane 2: CSB-PA017340ESR2HU (4μg) + Hela whole cell lysate (500μg)
Lane 3: Hela whole cell lysate (20μg)
P4HA2 Antibodies
P4HA2 for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 種屬反應性 | 應用類型 |
|---|---|---|---|
| CSB-PA017340GA01HU | P4HA2 Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-PA017340ESR1HU | P4HA2 Antibody | Human | ELISA, WB, IHC, IP |
| CSB-PA017340ESR2HU | P4HA2 Antibody | Human | ELISA, IHC, IP |
P4HA2 Proteins
P4HA2 Proteins for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP017340HU CSB-EP017340HU CSB-BP017340HU CSB-MP017340HU CSB-EP017340HU-B |
Recombinant Human Prolyl 4-hydroxylase subunit alpha-2 (P4HA2) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
