P4HA2 Antibody

說明書

中文名稱：

P4HA2兔多克隆抗體
貨號：

CSB-PA017340ESR2HU
規格：

￥440
圖片：
Immunohistochemistry of paraffin-embedded human breast cancer using CSB-PA017340ESR2HU at dilution of 1:100

Immunohistochemistry of paraffin-embedded human placenta tissue using CSB-PA017340ESR2HU at dilution of 1:100

Immunoprecipitating P4HA2 in Hela whole cell lysate
Lane 1: Rabbit control IgG instead of (1μg) instead of CSB-PA017340ESR2HU in Hela whole cell lysate. For western blotting, a HRP-conjugated anti-rabbit IgG, specific to the non-reduced form of IgG was used as the Secondary antibody (1/50000)
Lane 2: CSB-PA017340ESR2HU (4μg) + Hela whole cell lysate (500μg)
Lane 3: Hela whole cell lysate (20μg)
其他：

產品詳情
產品評價
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靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) P4HA2 Polyclonal antibody
Uniprot No.：

O15460
基因名：

P4HA2
別名：

2-oxoglutarate-4-dioxygenase subunit alpha-2 antibody; 4 PH alpha 2 antibody; 4-PH alpha-2 antibody; C-P4Halpha(II) antibody; collagen prolyl 4-hydroxylase alpha(II) antibody; P4HA2 antibody; P4HA2_HUMAN antibody; procollagen proline, 2 oxoglutarate 4 dioxygenase (proline 4 hydroxylase), alpha polypeptide II antibody; procollagen proline, 2 oxoglutarate 4 dioxygenase alpha subunit, isoform 2 antibody; Procollagen-proline antibody; procollagen-proline,2-oxoglutarate-4-dioxygenase subunit alpha-2 antibody; Prolyl 4 hydroxylase alpha 2 subunit antibody; Prolyl 4 hydroxylase subunit alpha 2 [Precursor] antibody; Prolyl 4-hydroxylase subunit alpha-2 antibody; Prolyl 4-hydroxylase, alpha polypeptide II antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human Prolyl 4-hydroxylase subunit alpha-2 protein (236-535AA)
免疫原種屬：

Homo sapiens (Human)
標記方式：

Non-conjugated
克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

Antigen Affinity Purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
產品提供形式：

Liquid
應用范圍：

ELISA, IHC, IP

推薦稀釋比：

Application	Recommended Dilution
IHC	1:20-1:200
IP	1:200-1:2000

Protocols：

ELISA Protocol
Immunohistochemistry (IHC) Protocol
Immunoprecipitation (IP) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Catalyzes the post-translational formation of 4-hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins.
基因功能參考文獻：
1. Assembly of the elongated collagen prolyl 4-hydroxylase alpha2beta2 heterotetramer around a central alapha2 dimer has been reported. PMID: 28093469
2. Plasminogen and P4HA2 are involved in vascular remodelling and angiogenesis, suggesting a high relevance of these processes for the pathogenic mechanisms underlying this type of vasculitis PMID: 28041642
3. RNAsequencing showed that the t(4;5)(q24;q31) resulted in recombination of the genes TBCK on 4q24 and P4HA2 on 5q31.1 with generation of an inframe TBCKP4HA2 and the reciprocal but outofframe P4HA2TBCK fusion transcripts. PMID: 27633981
4. P4HA2 was identified as a novel causative gene for nonsyndromic high myopia. PMID: 25741866
5. Suggest the critical role of P4HA2 in breast cancer progression and identify P4HA2 as a potential therapeutic target and biomarker for breast cancer progression. PMID: 24383403
6. Hypoxia-inducible factor 1 (HIF-1) promotes extracellular matrix remodeling under hypoxic conditions by inducing P4HA1, P4HA2, and PLOD2 expression in fibroblasts. PMID: 23423382
7. P4HA2 was upregulated in breast tumor cells compared with its adjacent normal tissues. PMID: 22813596
8. Overexpression of PRDX4 and P4HA2 was significantly associated with lymphatic metastasis in oral cavity squamous cell carcinoma PMID: 21859152
9. the substrate specificity, binding site and conformation of this enzyme PMID: 12824157
10. In comparison with healthy cartilage, Osteoarthritis articular chondrocytes exhibit increased in vivo synthesis of collagen prolyl-4-hydroxylase type II, a pivotal enzyme in collagen triple helix formation. PMID: 16877351
11. HIF-P4H, HIF-1alpha and HIF-2alpha are effective oxygen sensors PMID: 16885164
12. results show that p53 transcriptionally activates the alpha(II) collagen prolyl-4-hydroxylase [alpha(II)PH] gene, resulting in the extracellular release of antiangiogenic fragments of collagen type 4 and 18 PMID: 16917063
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相關疾病：

Myopia 25, autosomal dominant (MYP25)
亞細胞定位：

Endoplasmic reticulum lumen.
蛋白家族：

P4HA family
數據庫鏈接：

HGNC: 8547

OMIM: 600608

KEGG: hsa:8974

STRING: 9606.ENSP00000166534

UniGene: Hs.519568

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