P4HA2 Antibody
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中文名稱：P4HA2兔多克隆抗體
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貨號(hào)：CSB-PA017340GA01HU
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規(guī)格：￥3,900
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其他：
產(chǎn)品詳情
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Uniprot No.：
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基因名：
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別名：2-oxoglutarate-4-dioxygenase subunit alpha-2 antibody; 4 PH alpha 2 antibody; 4-PH alpha-2 antibody; C-P4Halpha(II) antibody; collagen prolyl 4-hydroxylase alpha(II) antibody; P4HA2 antibody; P4HA2_HUMAN antibody; procollagen proline, 2 oxoglutarate 4 dioxygenase (proline 4 hydroxylase), alpha polypeptide II antibody; procollagen proline, 2 oxoglutarate 4 dioxygenase alpha subunit, isoform 2 antibody; Procollagen-proline antibody; procollagen-proline,2-oxoglutarate-4-dioxygenase subunit alpha-2 antibody; Prolyl 4 hydroxylase alpha 2 subunit antibody; Prolyl 4 hydroxylase subunit alpha 2 [Precursor] antibody; Prolyl 4-hydroxylase subunit alpha-2 antibody; Prolyl 4-hydroxylase, alpha polypeptide II antibody
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宿主：Rabbit
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反應(yīng)種屬：Human,Mouse,Rat
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免疫原：Human P4HA2
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免疫原種屬：Homo sapiens (Human)
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抗體亞型：IgG
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純化方式：Antigen Affinity Purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
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產(chǎn)品提供形式：Liquid
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應(yīng)用范圍：ELISA,WB
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Protocols：
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儲(chǔ)存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產(chǎn)品評(píng)價(jià)
相關(guān)產(chǎn)品
靶點(diǎn)詳情
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功能：Catalyzes the post-translational formation of 4-hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins.
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基因功能參考文獻(xiàn)：
- Assembly of the elongated collagen prolyl 4-hydroxylase alpha2beta2 heterotetramer around a central alapha2 dimer has been reported. PMID: 28093469
- Plasminogen and P4HA2 are involved in vascular remodelling and angiogenesis, suggesting a high relevance of these processes for the pathogenic mechanisms underlying this type of vasculitis PMID: 28041642
- RNAsequencing showed that the t(4;5)(q24;q31) resulted in recombination of the genes TBCK on 4q24 and P4HA2 on 5q31.1 with generation of an inframe TBCKP4HA2 and the reciprocal but outofframe P4HA2TBCK fusion transcripts. PMID: 27633981
- P4HA2 was identified as a novel causative gene for nonsyndromic high myopia. PMID: 25741866
- Suggest the critical role of P4HA2 in breast cancer progression and identify P4HA2 as a potential therapeutic target and biomarker for breast cancer progression. PMID: 24383403
- Hypoxia-inducible factor 1 (HIF-1) promotes extracellular matrix remodeling under hypoxic conditions by inducing P4HA1, P4HA2, and PLOD2 expression in fibroblasts. PMID: 23423382
- P4HA2 was upregulated in breast tumor cells compared with its adjacent normal tissues. PMID: 22813596
- Overexpression of PRDX4 and P4HA2 was significantly associated with lymphatic metastasis in oral cavity squamous cell carcinoma PMID: 21859152
- the substrate specificity, binding site and conformation of this enzyme PMID: 12824157
- In comparison with healthy cartilage, Osteoarthritis articular chondrocytes exhibit increased in vivo synthesis of collagen prolyl-4-hydroxylase type II, a pivotal enzyme in collagen triple helix formation. PMID: 16877351
- HIF-P4H, HIF-1alpha and HIF-2alpha are effective oxygen sensors PMID: 16885164
- results show that p53 transcriptionally activates the alpha(II) collagen prolyl-4-hydroxylase [alpha(II)PH] gene, resulting in the extracellular release of antiangiogenic fragments of collagen type 4 and 18 PMID: 16917063
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相關(guān)疾病：Myopia 25, autosomal dominant (MYP25)
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亞細(xì)胞定位：Endoplasmic reticulum lumen.
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蛋白家族：P4HA family
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數(shù)據(jù)庫鏈接：
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