Recombinant Human Cytosolic 5'-nucleotidase 1A (NT5C1A)

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中文名稱：

人NT5C1A重組蛋白
貨號：

CSB-YP866304HU
說明書：

MSDS Datasheet
規格：

￥1500
圖片：
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
其他：

產品詳情
產品評價
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靶點詳情

產品詳情

純度：

Greater than 90% as determined by SDS-PAGE.
基因名：

NT5C1A
Uniprot No.：

Q9BXI3
別名：

5' nucleotidase cytosolic IA; 5NT1A_HUMAN; AMP specific 5' NT; CN I; CN IA; cN-I; cN-IA; CN1; cN1A; cNI; cNIA; Cytosolic 5' nucleotidase 1A; Cytosolic 5' nucleotidase IA; Cytosolic 5' nucleotidase type 1A; Cytosolic 5''-nucleotidase 1A; Cytosolic 5''-nucleotidase IA; MGC119199; MGC119201; NT5C1A; nucleotidase; 5-prime; cytosolic; IA
種屬：

Homo sapiens (Human)
蛋白長度：

Full Length
來源：

Yeast
分子量：

43.0kDa
表達區域：

1-368aa
氨基酸序列

MEPGQPREPQEPREPGPGAETAAAPVWEEAKIFYDNLAPKKKPKSPKPQNAVTIAVSSRALFRMDEEQQIYTEQGVEEYVRYQLEHENEPFSPGPAFPFVKALEAVNRRLRELYPDSEDVFDIVLMTNNHAQVGVRLINSINHYDLFIERFCMTGGNSPICYLKAYHTNLYLSADAEKVREAIDEGIAAATIFSPSRDVVVSQSQLRVAFDGDAVLFSDESERIVKAHGLDRFFEHEKAHENKPLAQGPLKGFLEALGRLQKKFYSKGLRLECPIRTYLVTARSAASSGARALKTLRSWGLETDEALFLAGAPKGPLLEKIRPHIFFDDQMFHVAGAQEMGTVAAHVPYGVAQTPRRTAPAKQAPSAQ
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
蛋白標簽：

N-terminal 6xHis-tagged
產品提供形式：

Liquid or Lyophilized powder Warning: in_array() expects parameter 2 to be array, null given in /www/web/cusabio_cn/public_html/caches/caches_template/default/content/show_product_protein.php on line 662
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
緩沖液：

If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol.
Note: If you have any special requirement for the glycerol content, please remark when you place the order.
If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

3-7 business days
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet & COA：

Please contact us to get it.

產品評價

靶點詳情

功能：

Dephosphorylates the 5' and 2'(3')-phosphates of deoxyribonucleotides and has a broad substrate specificity. Helps to regulate adenosine levels in heart during ischemia and hypoxia.
基因功能參考文獻：
1. Individual missense changes in NT5C1A showed considerable variation in response to the different nucleoside analogs tested. PMID: 26906009
2. seropositivity to the NT5c1A antibody is associated with greater motor and functional disability in sporadic inclusion body myositis PMID: 25857661
3. Anti-NT5C1A is a common target of circulating autoantibodies in autoimmune diseases. PMID: 25892010
4. NT5C1A suppression promotes AMP-activated protein kinase (AMPK) phosphorylation and metabolism in human and mouse skeletal muscle PMID: 21873433
5. overexpression of 5'-nucleotidase inhibits Natural Killer cell cytotoxicity to ameliorate rejection after xenotransplantation PMID: 15888028
6. deoxycytidine kinase, deoxyguanosine kinase, and cytosolic 5'-nucleotidase I are regulated in a cell cycle-dependent manner in MOLT-4 cells PMID: 17065091
7. There was no correlation between expression of cN-I and fiber type. PMID: 19352542
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亞細胞定位：

Cytoplasm.
蛋白家族：

5'-nucleotidase type 3 family
組織特異性：

Highly expressed in skeletal muscle. Detected at intermediate levels in heart, brain, kidney and pancreas.
數據庫鏈接：

HGNC: 17819

OMIM: 610525

KEGG: hsa:84618

STRING: 9606.ENSP00000235628

UniGene: Hs.307006