Recombinant Human Cytosolic 5'-nucleotidase 1A (NT5C1A)

中文名稱：

人NT5C1A重組蛋白
貨號：

CSB-EP866304HU
說明書：

MSDS Datasheet
規(guī)格：
來源：

E.coli
其他：

中文名稱：

人NT5C1A重組蛋白
貨號：

CSB-EP866304HU-B
說明書：

MSDS Datasheet
規(guī)格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

人NT5C1A重組蛋白
貨號：

CSB-BP866304HU
說明書：

MSDS Datasheet
規(guī)格：
來源：

Baculovirus
其他：

中文名稱：

人NT5C1A重組蛋白
貨號：

CSB-MP866304HU
說明書：

MSDS Datasheet
規(guī)格：
來源：

Mammalian cell
其他：

產(chǎn)品詳情
產(chǎn)品評價
相關(guān)產(chǎn)品
靶點詳情

產(chǎn)品詳情

純度：

Greater than 85% as determined by SDS-PAGE.
基因名：

NT5C1A
Uniprot No.：

Q9BXI3
別名：

5' nucleotidase cytosolic IA; 5NT1A_HUMAN; AMP specific 5' NT; CN I; CN IA; cN-I; cN-IA; CN1; cN1A; cNI; cNIA; Cytosolic 5' nucleotidase 1A; Cytosolic 5' nucleotidase IA; Cytosolic 5' nucleotidase type 1A; Cytosolic 5''-nucleotidase 1A; Cytosolic 5''-nucleotidase IA; MGC119199; MGC119201; NT5C1A; nucleotidase; 5-prime; cytosolic; IA
種屬：

Homo sapiens (Human)
蛋白長度：

Full length
表達區(qū)域：

1-368aa
氨基酸序列

MEPGQPREPQEPREPGPGAETAAAPVWEEAKIFYDNLAPKKKPKSPKPQNAVTIAVSSRALFRMDEEQQIYTEQGVEEYVRYQLEHENEPFSPGPAFPFVKALEAVNRRLRELYPDSEDVFDIVLMTNNHAQVGVRLINSINHYDLFIERFCMTGGNSPICYLKAYHTNLYLSADAEKVREAIDEGIAAATIFSPSRDVVVSQSQLRVAFDGDAVLFSDESERIVKAHGLDRFFEHEKAHENKPLAQGPLKGFLEALGRLQKKFYSKGLRLECPIRTYLVTARSAASSGARALKTLRSWGLETDEALFLAGAPKGPLLEKIRPHIFFDDQMFHVAGAQEMGTVAAHVPYGVAQTPRRTAPAKQAPSAQ
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產(chǎn)品提供形式：

Lyophilized powder Warning: in_array() expects parameter 2 to be array, null given in /www/web/cusabio_cn/public_html/caches/caches_template/default/content/show_product_protein.php on line 662
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復(fù)溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質(zhì)期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產(chǎn)品評價

靶點詳情

功能：

Dephosphorylates the 5' and 2'(3')-phosphates of deoxyribonucleotides and has a broad substrate specificity. Helps to regulate adenosine levels in heart during ischemia and hypoxia.
基因功能參考文獻：
1. Individual missense changes in NT5C1A showed considerable variation in response to the different nucleoside analogs tested. PMID: 26906009
2. seropositivity to the NT5c1A antibody is associated with greater motor and functional disability in sporadic inclusion body myositis PMID: 25857661
3. Anti-NT5C1A is a common target of circulating autoantibodies in autoimmune diseases. PMID: 25892010
4. NT5C1A suppression promotes AMP-activated protein kinase (AMPK) phosphorylation and metabolism in human and mouse skeletal muscle PMID: 21873433
5. overexpression of 5'-nucleotidase inhibits Natural Killer cell cytotoxicity to ameliorate rejection after xenotransplantation PMID: 15888028
6. deoxycytidine kinase, deoxyguanosine kinase, and cytosolic 5'-nucleotidase I are regulated in a cell cycle-dependent manner in MOLT-4 cells PMID: 17065091
7. There was no correlation between expression of cN-I and fiber type. PMID: 19352542
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亞細胞定位：

Cytoplasm.
蛋白家族：

5'-nucleotidase type 3 family
組織特異性：

Highly expressed in skeletal muscle. Detected at intermediate levels in heart, brain, kidney and pancreas.
數(shù)據(jù)庫鏈接：

HGNC: 17819

OMIM: 610525

KEGG: hsa:84618

STRING: 9606.ENSP00000235628

UniGene: Hs.307006