CTPS1 Recombinant Monoclonal Antibody
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中文名稱：CTPS1重組抗體
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貨號(hào)：CSB-RA548305A0HU
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規(guī)格：￥1320
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圖片：
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IHC image of CSB-RA548305A0HU diluted at 1:100 and staining in paraffin-embedded human salivary gland tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-rabbit polymer IgG labeled by HRP and visualized using 0.05% DAB.
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其他：
產(chǎn)品詳情
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產(chǎn)品描述：CTPS1 Recombinant Monoclonal Antibody（CSB-RA548305A0HU）是針對(duì)胞苷三磷酸合成酶1（CTPS1）開發(fā)的高特異性科研試劑，該靶點(diǎn)作為嘧啶核苷酸生物合成通路中的關(guān)鍵限速酶，通過催化UTP轉(zhuǎn)化為CTP參與DNA/RNA合成，在細(xì)胞增殖調(diào)控及腫瘤發(fā)生發(fā)展中具有重要作用。本抗體采用重組技術(shù)制備，經(jīng)ELISA和免疫組化（IHC）雙重驗(yàn)證，在石蠟包埋組織切片中展現(xiàn)優(yōu)異的抗原識(shí)別能力，推薦使用濃度范圍為1:50至1:200時(shí)可獲得清晰的胞內(nèi)定位信號(hào)，適用于檢測(cè)多種生物樣本中CTPS1蛋白的表達(dá)水平。憑借單克隆抗體特有的高批次一致性，該產(chǎn)品可為腫瘤生物學(xué)研究、細(xì)胞代謝機(jī)制探索以及增殖相關(guān)疾病模型的建立提供可靠工具，特別適用于癌癥發(fā)生機(jī)制、藥物靶點(diǎn)篩選和細(xì)胞周期調(diào)控等基礎(chǔ)研究領(lǐng)域。
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Uniprot No.：
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基因名：CTPS1
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別名：CTP synthase 1 (EC 6.3.4.2) (CTP synthetase 1) (UTP--ammonia ligase 1), CTPS1, CTPS
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反應(yīng)種屬：Human
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免疫原：A synthesized peptide derived from human CTPS1
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免疫原種屬：Homo sapiens (Human)
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標(biāo)記方式：Non-conjugated
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克隆類型：Monoclonal
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抗體亞型：Rabbit IgG
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純化方式：Affinity-chromatography
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克隆號(hào)：13B6
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Rabbit IgG in 10mM phosphate buffered saline , pH 7.4, 150mM sodium chloride, 0.05% BSA, 0.02% sodium azide and 50% glycerol.
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產(chǎn)品提供形式：Liquid
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應(yīng)用范圍：ELISA, IHC
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推薦稀釋比：
Application Recommended Dilution IHC 1:50-1:200 -
Protocols：
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儲(chǔ)存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產(chǎn)品評(píng)價(jià)
相關(guān)產(chǎn)品
靶點(diǎn)詳情
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功能：This enzyme is involved in the de novo synthesis of CTP, a precursor of DNA, RNA and phospholipids. Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as a source of nitrogen. This enzyme and its product, CTP, play a crucial role in the proliferation of activated lymphocytes and therefore in immunity.
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基因功能參考文獻(xiàn)：
- CTP synthase forms the cytoophidium in human hepatocellular carcinoma. PMID: 29097181
- The filament structures elucidate allosteric mechanisms of assembly and regulation that rely on a conserved conformational equilibrium. The findings may provide a mechanism for increasing human CTP synthase activity in response to metabolic state and challenge the assumption that metabolic filaments are generally storage forms of inactive enzymes. PMID: 28459447
- Rods and rings (RR) are protein assemblies composed of CTPS1 and IMPDH2. Glutamine deprivation initiates reversible assembly of mammalian rods and rings. PMID: 24477477
- results highlight a key and specific role of CTPS1 in the immune system by its capacity to sustain the proliferation of activated lymphocytes during the immune response PMID: 24870241
- analysis of the kinetic properties of hCTPS1 and hCTPS2, and determination that Ser(68) is a major site of CTPS2 regulation by phosphorylation PMID: 20739275
- CTP synthetase is phosphorylated by protein kinase A PMID: 16179339
- Data indicate that protein kinase C phosphorylation at Ser(462) stimulates human CTP synthetase 1 activity, whereas phosphorylation at Thr(455) inhibits activity. PMID: 17463002
- analysis of phosphorylation and regulation of human CTPS1 in human cells shows that GSK3 is a novel regulator of CTPS activity PMID: 17681942
- studies provide novel information on the potential interacting proteins that may regulate CTPS1 function or intracellular localization PMID: 18600551
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相關(guān)疾病：Immunodeficiency 24 (IMD24)
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亞細(xì)胞定位：Cytoplasm, cytosol.
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蛋白家族：CTP synthase family
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組織特異性：Widely expressed.
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數(shù)據(jù)庫(kù)鏈接：
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