CTPS1 Antibody, FITC conjugated
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中文名稱：CTPS1兔多克隆抗體, FITC偶聯
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貨號：CSB-PA006176LC01HU
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規格：￥880
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其他：
產品詳情
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產品名稱：Rabbit anti-Homo sapiens (Human) CTPS1 Polyclonal antibody
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Uniprot No.：
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基因名：CTPS1
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別名：CTPS1 antibody; CTPS antibody; CTP synthase 1 antibody; EC 6.3.4.2 antibody; CTP synthetase 1 antibody; UTP--ammonia ligase 1 antibody
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宿主：Rabbit
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反應種屬：Human
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免疫原：Recombinant Human CTP synthase 1 protein (300-554AA)
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免疫原種屬：Homo sapiens (Human)
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標記方式：FITC
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克隆類型：Polyclonal
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抗體亞型：IgG
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純化方式：>95%, Protein G purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 -
產品提供形式：Liquid
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
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靶點詳情
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功能：This enzyme is involved in the de novo synthesis of CTP, a precursor of DNA, RNA and phospholipids. Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as a source of nitrogen. This enzyme and its product, CTP, play a crucial role in the proliferation of activated lymphocytes and therefore in immunity.
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基因功能參考文獻：
- CTP synthase forms the cytoophidium in human hepatocellular carcinoma. PMID: 29097181
- The filament structures elucidate allosteric mechanisms of assembly and regulation that rely on a conserved conformational equilibrium. The findings may provide a mechanism for increasing human CTP synthase activity in response to metabolic state and challenge the assumption that metabolic filaments are generally storage forms of inactive enzymes. PMID: 28459447
- Rods and rings (RR) are protein assemblies composed of CTPS1 and IMPDH2. Glutamine deprivation initiates reversible assembly of mammalian rods and rings. PMID: 24477477
- results highlight a key and specific role of CTPS1 in the immune system by its capacity to sustain the proliferation of activated lymphocytes during the immune response PMID: 24870241
- analysis of the kinetic properties of hCTPS1 and hCTPS2, and determination that Ser(68) is a major site of CTPS2 regulation by phosphorylation PMID: 20739275
- CTP synthetase is phosphorylated by protein kinase A PMID: 16179339
- Data indicate that protein kinase C phosphorylation at Ser(462) stimulates human CTP synthetase 1 activity, whereas phosphorylation at Thr(455) inhibits activity. PMID: 17463002
- analysis of phosphorylation and regulation of human CTPS1 in human cells shows that GSK3 is a novel regulator of CTPS activity PMID: 17681942
- studies provide novel information on the potential interacting proteins that may regulate CTPS1 function or intracellular localization PMID: 18600551
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相關疾病：Immunodeficiency 24 (IMD24)
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亞細胞定位：Cytoplasm, cytosol.
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蛋白家族：CTP synthase family
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組織特異性：Widely expressed.
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數據庫鏈接：
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