THEMIS Antibody, FITC conjugated
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中文名稱：THEMIS兔多克隆抗體, FITC偶聯
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貨號：CSB-PA850780LC01HU
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規格：￥880
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其他：
產品詳情
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產品名稱：Rabbit anti-Homo sapiens (Human) THEMIS Polyclonal antibody
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Uniprot No.：
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基因名：THEMIS
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別名：C6orf190 antibody; C6orf207 antibody; MGC163388 antibody; Protein THEMIS antibody; SIGNALING PHOSPHOPROTEIN SPECIFIC FOR T CELLS antibody; SPOT antibody; THEMIS antibody; THMS1_HUMAN antibody; Thymocyte expressed molecule involved in selection antibody; Thymocyte selection associated antibody; Thymocyte selection pathway associated antibody; Thymocyte-expressed molecule involved in selection antibody; TSEPA antibody
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宿主：Rabbit
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反應種屬：Human
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免疫原：Recombinant Human Protein THEMIS protein (547-641AA)
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免疫原種屬：Homo sapiens (Human)
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標記方式：FITC
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克隆類型：Polyclonal
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抗體亞型：IgG
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純化方式：>95%, Protein G purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 -
產品提供形式：Liquid
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：Plays a central role in late thymocyte development by controlling both positive and negative T-cell selection. Required to sustain and/or integrate signals required for proper lineage commitment and maturation of T-cells. Regulates T-cell development through T-cell antigen receptor (TCR) signaling and in particular through the regulation of calcium influx and phosphorylation of Erk.
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基因功能參考文獻：
- we have demonstrated mutually exclusive use of exon 1 and 2 amongst 16 novel THEMIS isoforms. We also show inverse correlation between THEMIS expression in human CD4+ T-cells and dosage of the multiple sclerosis risk allele at rs13204742, driven by reduced expression of exon 1- containing isoforms PMID: 27438997
- we found that THEMIS directly regulated the catalytic activity of the tyrosine phosphatase SHP-1. PMID: 28250424
- the THEMIS:SHP complex dampens early TCR signalling by a previously unknown molecular mechanism that favours T-cell survival. PMID: 25535246
- THEMIS showed higher mRNA expression in active celiac disease compared with treated patients and controls. PMID: 23820479
- THEMIS binding to GRB2 was required for thymocyte development. PMID: 23460737
- Themis1 exhibits the same potential to restore T cell development and T cell receptor-mediated signaling in Themis1-deficient mice. PMID: 22732588
- SPOP mutations may define a new molecular subtype of prostate cancer. PMID: 22610119
- specific role for THEMIS in early TCR signalosome function PMID: 21189249
- Observational study of gene-disease association. (HuGE Navigator) PMID: 19913121
- Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) PMID: 20628086
- Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator) PMID: 20095854
- Functional characterization of the homologous mouse gene. PMID: 19597498
- Functional analysis of the mouse gene by knockout, and comparison of the mouse and human proteins. PMID: 19597499
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亞細胞定位：Cytoplasm. Nucleus.
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蛋白家族：Themis family
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數據庫鏈接：
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