STAG3 Antibody
-
中文名稱：STAG3兔多克隆抗體
-
貨號：CSB-PA167892
-
規(guī)格：￥2024
-
圖片：
-
Western blot analysis of extracts from Jurkat cells, using STAG3 antibody.
-
-
其他：
產(chǎn)品詳情
-
產(chǎn)品名稱：Rabbit anti-Homo sapiens (Human) STAG3 Polyclonal antibody
-
Uniprot No.：
-
基因名：STAG3
-
宿主：Rabbit
-
反應種屬：Human
-
免疫原：Synthesized peptide derived from C-terminal of Human STAG3.
-
免疫原種屬：Homo sapiens (Human)
-
克隆類型：Polyclonal
-
純化方式：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
-
濃度：It differs from different batches. Please contact us to confirm it.
-
產(chǎn)品提供形式：Liquid
-
應用范圍：ELISA,WB
-
推薦稀釋比：
Application Recommended Dilution WB 1:500-1:3000 -
Protocols：
-
儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
-
貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
-
用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產(chǎn)品評價
相關產(chǎn)品
靶點詳情
-
功能：Meiosis specific component of cohesin complex. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The meiosis-specific cohesin complex probably replaces mitosis specific cohesin complex when it dissociates from chromatin during prophase I.
-
基因功能參考文獻：
- c.677C > G associated with primary ovarian insufficiency PMID: 28802712
- Loss of STAG2 or STAG3, which encode subunits of the cohesin complex, in melanoma cells results in resistance to BRAF inhibitors (BRAFi). Loss-of-function mutations in STAG2, as well as decreased expression of STAG2 or STAG3 proteins were found in several tumor samples from patients with acquired resistance to BRAFi and in BRAFi-resistant melanoma cell lines. PMID: 27500726
- STAG3 truncating variant as the cause of primary ovarian insufficiency has been found in two sisters in a consanguineous Lebanese family. PMID: 26059840
- We identified a homozygous 1-bp deletion inducing a frameshift mutation in STAG3 on chromosome 7. Female mice devoid of Stag3 are sterile. PMID: 24597867
- we show evidence for the involvement of a common allele of STAG3 in the development of epithelial ovarian cancer PMID: 20635389
- identified as one of five genes containing 11 somatic mutations in a panel that included 132 colorectal cancers, then demonstrated that down-regulation of such homologs resulted in chromosomal instability and chromatid cohesion defects in human cells PMID: 18299561
- plays a role in regulation of transcription due to genetic imprinting, sister chromatid exchange, chromosome segregation and as an insulator element. (review) PMID: 18788457
顯示更多
收起更多
-
相關疾?。?/div>Premature ovarian failure 8 (POF8)亞細胞定位：Nucleus. Chromosome. Chromosome, centromere.蛋白家族：SCC3 family組織特異性：Testis specific.數(shù)據(jù)庫鏈接：
Most popular with customers
-
-
YWHAB Recombinant Monoclonal Antibody
Applications: ELISA, WB, IHC, IF, FC
Species Reactivity: Human, Mouse, Rat
-
Phospho-YAP1 (S127) Recombinant Monoclonal Antibody
Applications: ELISA, WB, IHC
Species Reactivity: Human
-
-
-
-
-
