STAG3 Antibody, Biotin conjugated
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中文名稱：STAG3兔多克隆抗體, Biotin偶聯
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貨號：CSB-PA022787LD01HU
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規格：￥880
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其他：
產品詳情
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產品名稱：Rabbit anti-Homo sapiens (Human) STAG3 Polyclonal antibody
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Uniprot No.：
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基因名：STAG3
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別名：STAG3 antibody; Cohesin subunit SA-3 antibody; SCC3 homolog 3 antibody; Stromal antigen 3 antibody; Stromalin-3 antibody
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宿主：Rabbit
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反應種屬：Human
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免疫原：Recombinant Human Cohesin subunit SA-3 protein (1056-1212AA)
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免疫原種屬：Homo sapiens (Human)
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標記方式：Biotin
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克隆類型：Polyclonal
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抗體亞型：IgG
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純化方式：>95%, Protein G purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 -
產品提供形式：Liquid
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應用范圍：ELISA
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Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：Meiosis specific component of cohesin complex. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The meiosis-specific cohesin complex probably replaces mitosis specific cohesin complex when it dissociates from chromatin during prophase I.
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基因功能參考文獻：
- c.677C > G associated with primary ovarian insufficiency PMID: 28802712
- Loss of STAG2 or STAG3, which encode subunits of the cohesin complex, in melanoma cells results in resistance to BRAF inhibitors (BRAFi). Loss-of-function mutations in STAG2, as well as decreased expression of STAG2 or STAG3 proteins were found in several tumor samples from patients with acquired resistance to BRAFi and in BRAFi-resistant melanoma cell lines. PMID: 27500726
- STAG3 truncating variant as the cause of primary ovarian insufficiency has been found in two sisters in a consanguineous Lebanese family. PMID: 26059840
- We identified a homozygous 1-bp deletion inducing a frameshift mutation in STAG3 on chromosome 7. Female mice devoid of Stag3 are sterile. PMID: 24597867
- we show evidence for the involvement of a common allele of STAG3 in the development of epithelial ovarian cancer PMID: 20635389
- identified as one of five genes containing 11 somatic mutations in a panel that included 132 colorectal cancers, then demonstrated that down-regulation of such homologs resulted in chromosomal instability and chromatid cohesion defects in human cells PMID: 18299561
- plays a role in regulation of transcription due to genetic imprinting, sister chromatid exchange, chromosome segregation and as an insulator element. (review) PMID: 18788457
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相關疾病：Premature ovarian failure 8 (POF8)
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亞細胞定位：Nucleus. Chromosome. Chromosome, centromere.
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蛋白家族：SCC3 family
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組織特異性：Testis specific.
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數據庫鏈接：
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