STAG3 Antibody, FITC conjugated

說明書

中文名稱：

STAG3兔多克隆抗體, FITC偶聯
貨號：

CSB-PA022787LC01HU
規格：

￥880
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) STAG3 Polyclonal antibody
Uniprot No.：

Q9UJ98
基因名：

STAG3
別名：

STAG3 antibody; Cohesin subunit SA-3 antibody; SCC3 homolog 3 antibody; Stromal antigen 3 antibody; Stromalin-3 antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human Cohesin subunit SA-3 protein (1056-1212AA)
免疫原種屬：

Homo sapiens (Human)
標記方式：

FITC
克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
產品提供形式：

Liquid
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Meiosis specific component of cohesin complex. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The meiosis-specific cohesin complex probably replaces mitosis specific cohesin complex when it dissociates from chromatin during prophase I.
基因功能參考文獻：
1. c.677C > G associated with primary ovarian insufficiency PMID: 28802712
2. Loss of STAG2 or STAG3, which encode subunits of the cohesin complex, in melanoma cells results in resistance to BRAF inhibitors (BRAFi). Loss-of-function mutations in STAG2, as well as decreased expression of STAG2 or STAG3 proteins were found in several tumor samples from patients with acquired resistance to BRAFi and in BRAFi-resistant melanoma cell lines. PMID: 27500726
3. STAG3 truncating variant as the cause of primary ovarian insufficiency has been found in two sisters in a consanguineous Lebanese family. PMID: 26059840
4. We identified a homozygous 1-bp deletion inducing a frameshift mutation in STAG3 on chromosome 7. Female mice devoid of Stag3 are sterile. PMID: 24597867
5. we show evidence for the involvement of a common allele of STAG3 in the development of epithelial ovarian cancer PMID: 20635389
6. identified as one of five genes containing 11 somatic mutations in a panel that included 132 colorectal cancers, then demonstrated that down-regulation of such homologs resulted in chromosomal instability and chromatid cohesion defects in human cells PMID: 18299561
7. plays a role in regulation of transcription due to genetic imprinting, sister chromatid exchange, chromosome segregation and as an insulator element. (review) PMID: 18788457
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相關疾病：

Premature ovarian failure 8 (POF8)
亞細胞定位：

Nucleus. Chromosome. Chromosome, centromere.
蛋白家族：

SCC3 family
組織特異性：

Testis specific.
數據庫鏈接：

HGNC: 11356

OMIM: 608489

KEGG: hsa:10734

STRING: 9606.ENSP00000319318

UniGene: Hs.592283

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