PTCH2 Antibody

中文名稱：

PTCH2兔多克隆抗體
貨號：

CSB-PA896928LA01HU
規格：

￥440
圖片：
IHC image of CSB-PA896928LA01HU diluted at 1:200 and staining in paraffin-embedded human brain tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

Immunofluorescence staining of 293 cells with CSB-PA896928LA01HU at 1:66, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
其他：

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) PTCH2 Polyclonal antibody
Uniprot No.：

Q9Y6C5
基因名：

PTCH2
別名：

patched (Drosophila) homolog 2 antibody; patched homolog 2 (Drosophila) antibody; Protein patched homolog 2 antibody; PTC2 antibody; PTC2_HUMAN antibody; Ptch2 antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human Protein patched homolog 2 protein (793-951AA)
免疫原種屬：

Homo sapiens (Human)

標記方式：

Non-conjugated

本頁面中的產品，PTCH2 Antibody (CSB-PA896928LA01HU)，的標記方式是Non-conjugated。對于PTCH2 Antibody，我們還提供其他標記。見下表：

標記方式	貨號	產品名稱	應用
HRP	CSB-PA896928LB01HU	PTCH2 Antibody, HRP conjugated	ELISA
FITC	CSB-PA896928LC01HU	PTCH2 Antibody, FITC conjugated
Biotin	CSB-PA896928LD01HU	PTCH2 Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA, IHC, IF

推薦稀釋比：

Application	Recommended Dilution
IHC	1:200-1:500
IF	1:50-1:200

Protocols：

ELISA Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

功能：

Plays a role in the control of cellular growth. May have a role in epidermal development. May act as a receptor for Sonic hedgehog (SHH).
基因功能參考文獻：
1. Combined heterozygous germline mutations in PTCH1 and PTCH2 were identified in a patient with embryonal rhabdomyosarcoma. PMID: 29230040
2. Frameshift mutation in the PTCH2 gene can cause nevoid basal cell carcinoma syndrome. PMID: 23479190
3. PTCH2 isoforms have distinct roles in Hedgehog signalling. PMID: 14613484
4. PTCH2 (2157G-->A), a novel missense mutation, underlies NBCCS, resulting in the loss of PTCH2 inhibitory function in the Shh signalling pathway. PMID: 18285427
5. A susceptibility locus on 1p32-1p34 for congenital macrostomia in a Chinese family and identification of a novel PTCH2 mutation are reported. PMID: 19208383
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相關疾?。?/div>
Medulloblastoma (MDB); Basal cell carcinoma (BCC)
亞細胞定位：

Membrane; Multi-pass membrane protein.
蛋白家族：

Patched family
數據庫鏈接：

HGNC: 9586

OMIM: 155255

KEGG: hsa:8643

STRING: 9606.ENSP00000361266

UniGene: Hs.591497

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