PTCH2 Antibody

說明書

產品詳情

Uniprot No.：

Q9Y6C5
基因名：

PTCH2
別名：

patched (Drosophila) homolog 2 antibody; patched homolog 2 (Drosophila) antibody; Protein patched homolog 2 antibody; PTC2 antibody; PTC2_HUMAN antibody; Ptch2 antibody
宿主：

Rabbit
反應種屬：

Human,Mouse,Rat
免疫原：

Human PTCH2
免疫原種屬：

Homo sapiens (Human)
抗體亞型：

IgG
純化方式：

Antigen Affinity purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
產品提供形式：

Liquid
應用范圍：

ELISA,WB
Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

功能：

Plays a role in the control of cellular growth. May have a role in epidermal development. May act as a receptor for Sonic hedgehog (SHH).
基因功能參考文獻：
1. Combined heterozygous germline mutations in PTCH1 and PTCH2 were identified in a patient with embryonal rhabdomyosarcoma. PMID: 29230040
2. Frameshift mutation in the PTCH2 gene can cause nevoid basal cell carcinoma syndrome. PMID: 23479190
3. PTCH2 isoforms have distinct roles in Hedgehog signalling. PMID: 14613484
4. PTCH2 (2157G-->A), a novel missense mutation, underlies NBCCS, resulting in the loss of PTCH2 inhibitory function in the Shh signalling pathway. PMID: 18285427
5. A susceptibility locus on 1p32-1p34 for congenital macrostomia in a Chinese family and identification of a novel PTCH2 mutation are reported. PMID: 19208383
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相關疾病：

Medulloblastoma (MDB); Basal cell carcinoma (BCC)
亞細胞定位：

Membrane; Multi-pass membrane protein.
蛋白家族：

Patched family
數據庫鏈接：

HGNC: 9586

OMIM: 155255

KEGG: hsa:8643

STRING: 9606.ENSP00000361266

UniGene: Hs.591497

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