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中文名稱：大鼠促腎上腺皮質激素(ACTH)酶聯免疫試劑盒
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貨號：CSB-E06875r
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規格：96T/48T
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價格：￥3900/￥2500
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其他：
產品詳情
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產品描述：大鼠促腎上腺皮質激素(ACTH)酶聯免疫試劑盒（CSB-E06875r）為競爭法ELISA試劑盒，定量檢測血清、血漿、組織勻漿樣本中的ACTH含量。促腎上腺皮質激素（ACTH）是腺垂體分泌的調節腎上腺皮質活動的重要激素。其分泌受下丘腦促腎上腺皮質激素釋放激素調控。研究機制方面，它作用于腎上腺皮質，刺激皮質醇等糖皮質激素合成與分泌，在應激反應、代謝調節等生理過程中發揮關鍵作用。試劑盒檢測范圍為1.25 pg/mL-50 pg/mL，適用于評估實驗大鼠應激狀態下的激素水平變化、腎上腺皮質功能研究及藥物干預對神經內分泌系統的影響本品僅用于科研，不用于臨床診斷，產品具體參數及操作步驟詳見產品說明書。
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縮寫：ACTH
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種屬：Rattus norvegicus (Rat)
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樣本類型：serum, plasma, tissue homogenates
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檢測范圍：1.25 pg/mL-50 pg/mL
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靈敏度：1.25 pg/mL
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反應時間：1-5h
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樣本體積：50-100ul
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檢測波長：450 nm
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研究領域：Metabolism
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測定原理：quantitative
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測定方法：Competitive
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精密度：
Intra-assay Precision (Precision within an assay): CV%<15% Three samples of known concentration were tested twenty times on one plate to assess. Inter-assay Precision (Precision between assays): CV%<15% Three samples of known concentration were tested in twenty assays to assess. -
線性度：
To assess the linearity of the assay, samples were spiked with high concentrations of rat ACTH in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay. Sample Serum(n=4) 1:1 Average % 95 Range % 90-99 1:2 Average % 96 Range % 91-102 1:4 Average % 86 Range % 82-94 1:8 Average % 89 Range % 82-96 -
回收率：
The recovery of rat ACTH spiked to levels throughout the range of the assay in various matrices was evaluated. Samples were diluted prior to assay as directed in the Sample Preparation section. Sample Type Average % Recovery Range Serum (n=5) 90 86-96 EDTA plasma (n=4) 101 97-105 -
標準曲線：
These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed. 
pg/ml OD1 OD2 Average 50 0.341 0.340 0.341 25 0.476 0.474 0.475 11.5 0.700 0.713 0.707 3.75 1.056 1.067 1.062 1.25 1.468 1.387 1.428 0 1.945 1.864 1.905 -
數據處理：
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貨期：3-5 working days
引用文獻
- Association analysis of gut microbiota-metabolites-neuroendocrine changes in male rats acute exposure to simulated altitude of 5500 m J Wang,Scientific reports,2023
- Total Saikosaponins Attenuates Depression-Like Behaviors Induced by Chronic Unpredictable Mild Stress in Rats by Regulating the PI3K/AKT/NF-κB?… Z Zhou,Evidence-Based Complementary and Alternative Medicine,2022
- Jie-Yu-He-Huan Capsule Ameliorates Anxiety-Like Behaviours in Rats Exposed to Chronic Restraint Stress via the cAMP/PKA/CREB/BDNF Signalling Pathway Xiwen Geng,Oxidative Medicine and Cellular Longevity,2021
- Estrogen re-enhanced prenatal stress-related visceral sensitization and pain regulation J Chen,Research Square,2020
- The Involvement of Notch1 Signaling Pathway in Mid-aged Female Rats under Chronic Restraint Stress J Shen,Neuroscience Letters,2020
- Saponin extract of Baihe-Zhimu Tang ameliorates depression in chronic mild stress rats D Jia,Journal of Functional Foods,2020
- Vitamin D3 attenuates anxiety-like behavior in long-term ovariectomized rats with unpredictable mild stress BARANENKO D,BIOCELL,2019
- Metabolomic signatures and microbial community profiling of depressive rat model induced by adrenocorticotrophic hormone Song J, et al,Journal of Translational Medicine,2019
- The Effects of High Peripubertal Caffeine Exposure on the Adrenal Gland in Immature Male and Female Rats Ryu KY,Nutrients,2019
- Chronic paradoxical sleep deprivation-induced depression Ma W, et al,Life Sciences,2019
- Exposure to cell phone radiofrequency changes corticotrophin hormone levels and histology of the brain and adrenal glands in male Wistar rat Sima Shahabi.et al,Iranian Journal of Basic Medical Sciences,2018
- Social defeat stress before pregnancy induces depressive-like behaviours and cognitive deficits in adult male offspring: correlation with neurobiological changes Wei S.et al,BMC Neuroscience,2018
- Transplantation of bone marrow mesenchymal stem cells reduces GluR1 expression in the hippocampus and amygdala and affects secretion of stress-related hormones in rats with spinal cord injuries: a potential anti-chronic stress mechanism Jia-Jia Sun.et al,INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE,2018
- Perfluorooctane sulfonate (PFOS) can alter the hypothalamic?pituitary?adrenal (HPA) axis activity by modifying CRF1 and glucocorticoid receptors R. Salgado.et al,Toxicology Letters,2018
- Sini Decoction improves adrenal function and the short-term outcome of septic rats through downregulation of adrenal Toll-like receptor 4 expression Fang Lai.et al,/,2018
- A urinary metabolomics (GC-MS) strategy to evaluate the antidepressant-like effect of chlorogenic acid in adrenocorticotropic hormone-treated rats Le Zhao.et al, RSC Adv,2018
- Assessment of the role of intracranial hypertension and stress on hippocampal cell apoptosis and hypothalamic-pituitary dysfunction after TBI Tan H.et al,Sci Rep,2017
- Etomidate increases mortality in septic rats through inhibition of nuclear factor kappa-B rather than by causing adrenal insufficiency. Zhang Y.et al,J Surg Res.,2015
- High-Cholesterol Diet Disrupts the Levels of Hormones Derived from Anterior Pituitary Basophilic Cells Yang J.et al,J Neuroendocrinol.,2016
- Regulation of corticosterone secretion is modified by PFOS exposure at different levels of the hypothalamic-pituitary-adrenal axis in adult male rats Pereiro N et al,Toxicol Lett,2014
- Effects of simultaneous combined exposure to CDMA and WCDMA electromagnetic fields on serum hormone levels in rats Jin YB et al,J Radiat Res,2012
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靶點詳情
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最新研究進展：促腎上腺皮質激素（ACTH）是由下丘腦-垂體-腎上腺（HPA）軸分泌的激素，對于調節腎上腺皮質激素的合成和分泌具有重要作用。以下是最近一些關于ACTH的研究進展：ACTH在應激反應中的作用：ACTH參與了應激反應的調節。最近的研究表明，應激可以影響下丘腦的神經元活動，導致ACTH的分泌增加。而ACTH又可以刺激腎上腺皮質激素的合成和分泌，從而調節機體的應激反應。因此，ACTH也被廣泛應用于應激相關疾病的治療。ACTH在自身免疫性皮膚病中的作用：ACTH具有抗炎作用，已被廣泛用于治療自身免疫性皮膚病，如銀屑病和天皰瘡等。最近的研究表明，ACTH治療不僅可以減輕癥狀，還可以改善患者的生活質量。ACTH在兒童癲癇中的應用：ACTH在兒童癲癇治療中也有廣泛應用。最近的研究表明，ACTH治療可以顯著降低癲癇持續時間和頻率，同時改善兒童的認知和行為表現。ACTH在腎上腺皮質功能不足癥中的應用：ACTH也被用于治療腎上腺皮質功能不足癥，如原發性腎上腺皮質功能不足和副腎上腺皮質功能不足等。最近的研究表明，ACTH治療可以有效改善患者的癥狀和生活質量。
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