TNFSF8
CD30配體（CD30L）又名“CD153”或“腫瘤壞死因子配體家族成員8（TNFSF8）”，它是一種Ⅱ型糖蛋白，分子量為40kDa。CD30L蛋白有一個胞外區(qū)，構(gòu)成C端172個氨基酸，胞漿區(qū)為N端有40個氮基酸殘基。胞外區(qū)與TNF-a、TNF-β和CD40L有明顯的同源性，同其它TNF家族蛋白一樣，CD30L以三聚體形式存在。CD30L是否也像CD40L、TNF-a那樣有可溶性形式存在，目前還不清楚。CD30L除表達(dá)在許多髓質(zhì)上皮細(xì)胞外，也表達(dá)于外周血的中性粒細(xì)胞、嗜酸性粒細(xì)胞、靜止B細(xì)胞、活化的T細(xì)胞。靜止的T細(xì)胞不表達(dá)CD30L。大量的研究結(jié)果表明CD30與CD30L特異性結(jié)合后，才能產(chǎn)生活化信號，促發(fā)細(xì)胞內(nèi)信息傳遞過程，導(dǎo)致細(xì)胞增生、分化、細(xì)胞因子的分泌、細(xì)胞生長受阻或凋亡。目前，研究人員發(fā)現(xiàn)CD30/CD30L軸在自身免疫性疾病、某些病毒感染及腫瘤中發(fā)揮重要作用。
Recombinant Human TNFSF8 活性蛋白實(shí)驗(yàn)驗(yàn)證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Measured by its binding ability in a functional ELISA. Immobilized CD30(CSB-MP023983HU1h6) at 5 μg/ml can bind human CD30L, the EC50 is 9.531-12.49 ng/ml.
TNFSF8 Antibodies
TNFSF8 for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA951710 | TNFSF8 Antibody | Human,Mouse | ELISA,WB |
| CSB-PA006282 | TNFSF8 Antibody | Human | WB, ELISA |
| CSB-PA009041 | TNFSF8 Antibody | Human,Mouse | WB, IF, ELISA |
TNFSF8 Proteins
TNFSF8 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP023996HU1 CSB-EP023996HU1 CSB-BP023996HU1 CSB-EP023996HU1-B |
Recombinant Human Tumor necrosis factor ligand superfamily member 8 (TNFSF8), partial | Yeast E.coli Baculovirus In Vivo Biotinylation in E.coli |
| CSB-CF023996HU | Recombinant Human Tumor necrosis factor ligand superfamily member 8 (TNFSF8) | in vitro E.coli expression system |
| CSB-MP023996HU1 | Recombinant Human Tumor necrosis factor ligand superfamily member 8 (TNFSF8), partial (Active) | Mammalian cell |
| CSB-MP023996HU1c9 | Recombinant Human Tumor necrosis factor ligand superfamily member 8 (TNFSF8), partial (Active) | Mammalian cell |
TNFSF8 Proteins for Mus musculus (Mouse)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP023996MO1 CSB-EP023996MO1 CSB-BP023996MO1 CSB-MP023996MO1 CSB-EP023996MO1-B |
Recombinant Mouse Tumor necrosis factor ligand superfamily member 8 (Tnfsf8), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF023996MO | Recombinant Mouse Tumor necrosis factor ligand superfamily member 8 (Tnfsf8) | in vitro E.coli expression system |
TNFSF8 ELISA Kit
TNFSF8 ELISA Kit for Mus musculus (Mouse)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-E04715m | Mouse Soluble Cluster of differentiation 30 ligand,sCD30L ELISA Kit | serum, plasma, tissue homogenates | 0.039 ng/ml |
