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中文名稱：人可溶性腫瘤壞死因子樣凋亡微弱誘導劑(sTWEAK)酶聯免疫試劑盒
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貨號：CSB-E16492h
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規格：96T/48T
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價格：￥3600/￥2500
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其他：
產品詳情
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產品描述：人可溶性腫瘤壞死因子樣凋亡微弱誘導劑(sTWEAK)酶聯免疫試劑盒（CSB-E16492h）為雙抗夾心法ELISA試劑盒，定量檢測血清、血漿、組織勻漿樣本中的TNFSF12含量。TNFSF12，又稱TWEAK，是一種腫瘤壞死因子超家族成員，具有誘導細胞凋亡、促進血管生成和參與炎癥反應等功能。其通過與FN14受體結合，在腫瘤發生發展中發揮重要作用，并與多種疾病如肝癌、膽道閉鎖等密切相關。試劑盒檢測范圍為0.312 ng/ml-20 ng/ml，靈敏度為0.078 ng/ml。可用于細胞因子網絡研究、疾病動物模型驗證及生物標志物篩查等方向，支持體外實驗樣本中 sTWEAK 蛋白的精準定量分析。本品僅用于科研，不用于臨床診斷，產品具體參數及操作步驟詳見產品說明書。
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別名：APO 3 ligand ELISA Kit; APO 3L ELISA Kit; APO3 ligand ELISA Kit; APO3/DR3 ligand ELISA Kit; APO3L ELISA Kit; DR3LG ELISA Kit; MGC129581 ELISA Kit; MGC20669 ELISA Kit; secreted form ELISA Kit; TNF-related weak inducer of apoptosis ELISA Kit; TNF12_HUMAN ELISA Kit; TNFSF 12 ELISA Kit; Tnfsf12 ELISA Kit; TNFSF12 protein ELISA Kit; Tumor necrosis factor (ligand) superfamily member 12 ELISA Kit; Tumor necrosis factor ligand superfamily member 12 ELISA Kit; Tumor necrosis factor superfamily member 12 ELISA Kit; TWEAK ELISA Kit; UNQ181/PRO207 ELISA Kit
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縮寫：
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Uniprot No.：
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種屬：Homo sapiens (Human)
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樣本類型：serum, plasma, tissue homogenates
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檢測范圍：0.312 ng/ml-20 ng/ml
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靈敏度：0.078 ng/ml
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反應時間：1-5h
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樣本體積：50-100ul
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檢測波長：450 nm
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研究領域：Cardiovascular
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測定原理：quantitative
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測定方法：Sandwich
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精密度：
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線性度：
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回收率：
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標準曲線：
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數據處理：
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貨期：3-5 working days
引用文獻
- Increased Serum Concentrations of TNF-Like Weak Inducer of Apoptosis Predict Higher 28-Day Mortality in Patients with Sepsis Ying Guo, et al,Emergency Medicine International,2019
- Increased serum tumor necrosis factor receptor-associated factor-6 expression in patients with non-metastatic triple-negative breast cancer Cemil Bilir et al,Oncology Letters,2015
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相關產品
靶點詳情
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最新研究進展：TNFSF12是一種細胞因子，也被稱為TWEAK。最新的研究表明，它在肝癌等多種腫瘤的發生和進展中發揮著關鍵作用，并且可能成為治療這些腫瘤的新靶點之一。
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功能：Binds to FN14 and possibly also to TNRFSF12/APO3. Weak inducer of apoptosis in some cell types. Mediates NF-kappa-B activation. Promotes angiogenesis and the proliferation of endothelial cells. Also involved in induction of inflammatory cytokines. Promotes IL8 secretion.
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基因功能參考文獻：
- Observational study of gene-disease association. (HuGE Navigator) PMID: 19913121
- Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) PMID: 20628086
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亞細胞定位：Cell membrane; Single-pass type II membrane protein.; [Tumor necrosis factor ligand superfamily member 12, secreted form]: Secreted.; [Isoform TWE-PRIL]: Cell membrane; Single-pass membrane protein.
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蛋白家族：Tumor necrosis factor family
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組織特異性：Highly expressed in adult heart, pancreas, skeletal muscle, brain, colon, small intestine, lung, ovary, prostate, spleen, lymph node, appendix and peripheral blood lymphocytes. Low expression in kidney, testis, liver, placenta, thymus and bone marrow. Als
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數據庫鏈接：
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