PGAM1
PGAM1，全稱磷酸甘油酸變位酶1，是一種在糖酵解中發揮關鍵作用的酶，能促進3-磷酸甘油酸轉化為2-磷酸甘油酸。該蛋白常見別名包括PGAM1A、PGAM1B等。PGAM1在細胞新陳代謝和能量生產中起著至關重要的作用，與細胞增殖和存活密切相關。研究表明，PGAM1在多種癌癥中高表達，如胰腺癌、非小細胞肺癌等，且其表達量與患者預后相關，提示其可作為癌癥治療的潛在靶標。近年來，針對PGAM1的藥物研發取得顯著進展，復旦大學藥學院周璐課題組研發的新型PGAM1別構抑制劑HKB99，在非小細胞肺癌中展現出顯著的增殖和轉移抑制作用。此外，PGAM1抑制劑KH3在胰腺癌模型中也表現出良好的抑瘤效果。這些研究成果為開發具有全新作用機制的抗腫瘤藥物提供了新方向。
熱銷產品
PGAM1 Recombinant Monoclonal Antibody (CSB-RA935337A0HU)
驗證數據
Western Blot
Positive WB detected in: Hela whole cell lysate, 293 whole cell lysate, HepG2 whole cell lysate, NIH/3T3 whole cell lysate, A549 whole cell lysate, MCF-7 whole cell lysate, Mouse Brain whole cell lysate, Rat Brain whole cell lysate
All lanes: PGAM1 Antibody at 1:1000
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 28 kDa
Observed band size: 29 kDa
PGAM1 Antibodies
PGAM1 for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 種屬反應性 | 應用類型 |
|---|---|---|---|
| CSB-PA017834GA01HU | PGAM1 Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-RA935337A0HU | PGAM1 Recombinant Monoclonal Antibody | Human, Mouse, Rat | ELISA, WB |
PGAM1 Proteins
PGAM1 Proteins for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP017834HU CSB-EP017834HU CSB-BP017834HU CSB-MP017834HU CSB-EP017834HU-B |
Recombinant Human Phosphoglycerate mutase 1 (PGAM1) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
PGAM1 Proteins for Rattus norvegicus (Rat)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP017834RA CSB-EP017834RA CSB-BP017834RA CSB-MP017834RA CSB-EP017834RA-B |
Recombinant Rat Phosphoglycerate mutase 1 (Pgam1) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
PGAM1 Proteins for Bos taurus (Bovine)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP662256BO CSB-EP662256BO CSB-BP662256BO CSB-MP662256BO CSB-EP662256BO-B |
Recombinant Bovine Phosphoglycerate mutase 1 (PGAM1) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
PGAM1 Proteins for Pongo abelii (Sumatran orangutan)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP716235PYX CSB-EP716235PYX CSB-BP716235PYX CSB-MP716235PYX CSB-EP716235PYX-B |
Recombinant Pongo abelii Phosphoglycerate mutase 1 (PGAM1) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
PGAM1 Proteins for Gallus gallus (Chicken)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP726536CH CSB-EP726536CH CSB-BP726536CH CSB-MP726536CH CSB-EP726536CH-B |
Recombinant Chicken Phosphoglycerate mutase 1 (PGAM1) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
PGAM1 Proteins for Mus musculus (Mouse)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP875272MO CSB-EP875272MO CSB-BP875272MO CSB-MP875272MO CSB-EP875272MO-B |
Recombinant Mouse Phosphoglycerate mutase 1 (Pgam1) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
