PEAR1
PEAR1，即血小板內(nèi)皮聚集受體1，別名platelet endothelial aggregation receptor 1。這是一種主要在血小板和內(nèi)皮細(xì)胞上表達(dá)的跨膜受體，由23個(gè)外顯子和22個(gè)內(nèi)含子組成。PEAR1在血小板的活化和聚集過(guò)程中起著重要作用，參與多種血管相關(guān)疾病的發(fā)生發(fā)展。PEAR1的作用機(jī)制涉及與血小板表面的未知配體結(jié)合，介導(dǎo)血小板活化信號(hào)，以及調(diào)控內(nèi)皮細(xì)胞功能和介導(dǎo)血小板與內(nèi)皮細(xì)胞的相互作用。PEAR1對(duì)維持血管健康穩(wěn)態(tài)、血管損傷修復(fù)、調(diào)節(jié)血管內(nèi)皮功能具有重要作用。此外，PEAR1基因的多態(tài)性與血小板聚集能力以及血管功能有著密切的關(guān)系，是心血管疾病治療的潛在靶點(diǎn)。
熱銷(xiāo)產(chǎn)品
PEAR1 Antibody (CSB-PA017765LA01HU)
驗(yàn)證數(shù)據(jù)
Western Blot
Positive WB detected in: Rat liver tissue, Mouse kidney tissue
All lanes: PEAR1 antibody at 5.2μg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 111 kDa
Observed band size: 111 kDa
IHC image of CSB-PA017765LA01HU diluted at 1:400 and staining in paraffin-embedded human kidney tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
Immunofluorescence staining of U251 cells with CSB-PA017765LA01HU at 1:133, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
PEAR1 Antibodies
PEAR1 for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱(chēng) | 種屬反應(yīng)性 | 應(yīng)用類(lèi)型 |
|---|---|---|---|
| CSB-PA017765LA01HU | PEAR1 Antibody | Human, Rat, Mouse | ELISA, WB, IHC, IF |
| CSB-PA017765LB01HU | PEAR1 Antibody, HRP conjugated | Human | ELISA |
| CSB-PA017765LC01HU | PEAR1 Antibody, FITC conjugated | Human | |
| CSB-PA017765LD01HU | PEAR1 Antibody, Biotin conjugated | Human | ELISA |
PEAR1 Proteins
PEAR1 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱(chēng) | 來(lái)源 |
|---|---|---|
| CSB-YP017765HU CSB-EP017765HU CSB-BP017765HU CSB-MP017765HU CSB-EP017765HU-B |
Recombinant Human Platelet endothelial aggregation receptor 1 (PEAR1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
