PEAR1 Antibody

中文名稱：

PEAR1兔多克隆抗體
貨號：

CSB-PA017765LA01HU
規格：

￥440
圖片：
Western Blot
Positive WB detected in: Rat liver tissue, Mouse kidney tissue
All lanes: PEAR1 antibody at 5.2μg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 111 kDa
Observed band size: 111 kDa

IHC image of CSB-PA017765LA01HU diluted at 1:400 and staining in paraffin-embedded human kidney tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

Immunofluorescence staining of U251 cells with CSB-PA017765LA01HU at 1:133, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
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產品詳情

產品描述：

Rabbit polyclonal antibody anti-PEAR1 is suitable for use in ELISA, WB, IHC, and IF research applications. This PEAR1 antibody is developed in a rabbit against a recombinant protein corresponding to the amino acids 932-1037 of the human PEAR1. It undergoes protein G purification and exceeds 95% in purity. And it shows reactivity with human, mouse, and rat species.

The PEAR1 protein is involved in the signaling pathways that regulate platelet activation and aggregation. PEAR1 protein has also been implicated in other cellular processes, including cell adhesion, migration, and proliferation. Dysfunction of PEAR1 can cause some diseases, including cardiovascular disease, thrombosis, and stroke.
產品名稱：

Rabbit anti-Homo sapiens (Human) PEAR1 Polyclonal antibody
Uniprot No.：

Q5VY43
基因名：

PEAR1
別名：

hPEAR1 antibody; JEDI antibody; MEGF12 antibody; Multiple EGF-like domains protein 12 antibody; Multiple epidermal growth factor-like domains protein 12 antibody; Pear1 antibody; PEAR1_HUMAN antibody; Platelet endothelial aggregation receptor 1 antibody; RP11-107D16.3 antibody
宿主：

Rabbit
反應種屬：

Human, Rat, Mouse
免疫原：

Recombinant Human Platelet endothelial aggregation receptor 1 protein (932-1037AA)
免疫原種屬：

Homo sapiens (Human)

標記方式：

Non-conjugated

本頁面中的產品，PEAR1 Antibody (CSB-PA017765LA01HU)，的標記方式是Non-conjugated。對于PEAR1 Antibody，我們還提供其他標記。見下表：

標記方式	貨號	產品名稱	應用
HRP	CSB-PA017765LB01HU	PEAR1 Antibody, HRP conjugated	ELISA
FITC	CSB-PA017765LC01HU	PEAR1 Antibody, FITC conjugated
Biotin	CSB-PA017765LD01HU	PEAR1 Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA, WB, IHC, IF

推薦稀釋比：

Application	Recommended Dilution
WB	1:500-1:5000
IHC	1:200-1:500
IF	1:50-1:200

Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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靶點詳情

功能：

When overexpressed, reduces the number of both early and late non-adherent myeloid progenitor cells.
基因功能參考文獻：
1. PEAR1 rs56260937 minor allele was an independent predictor of revascularization events. PMID: 29212986
2. For Chinese patients with ACS treated with aspirin and clopidogrel, genetic mutations in rs822441/rs822442 in PEAR1 correlated significantly with platelet activity after adjusting for CYP2C19 *2/*3 alleles. PMID: 29407631
3. PEAR1 methylation corresponded to variability in expression of ISGL20L2, RRNAD1, MRLP24, HDGF and PRCC. PMID: 29614055
4. PEAR1 rs12041331 polymorphism may influence ticagrelor pharmacodynamics PMID: 27937053
5. DNA methylation at 4 different loci of PEAR1 during in vitro megakaryopoiesis, was studied. PMID: 27313330
6. In a White population, we could not replicate previous reports from experimental studies or obtained in patients suggesting that PEAR1 might be a susceptibility gene for cardiovascular complications PMID: 28449647
7. PEAR1 genetic variations were strongly associated with platelet reactivity in a Chinese patient population with coronary heart disease undergoing dual antiplatelet therapy with aspirin and clopidogrel. PMID: 26962983
8. A considerable portion of Chinese ischemic stroke patients are insensitive to aspirin treatment, which may be correlated with the MDR1 C3435T, TBXA2R (rs1131882), and PLA2G7 (rs1051931-rs7756935) polymorphisms. PMID: 27641736
9. in a Chinese pedigree, SNP rs778026543, but not rs1952294 and rs822442, may be a susceptibility for pulmonary thromboembolism PMID: 28002340
10. Platelet endothelial aggregation receptor-1: a novel modifier of neoangiogenesis. PMID: 26156496
11. Results suggest that genetic variation of PEAR1 is a significant determinant of endothelial function through pathways implicated in cardiovascular disease. PMID: 26406321
12. FcepsilonRI alpha-chain is an activating platelet endothelium aggregation receptor 1 (PEAR1) ligand. PMID: 25713122
13. genetic variability of GAS6 and PEAR1 genes may be associated with platelet hyperaggregability PMID: 25703520
14. A common genetic variant in PEAR1 (rs12041331) reproducibly influenced platelet aggregation in aspirin-treated patients with coronary artery disease. PMID: 25360888
15. study suggests that PEAR1 is not a hypertension susceptibility gene in humans. PMID: 25541647
16. The SNPs in two regions of the PEAR1 gene, from rs3737224 to rs822442, and from rs1214331 to rs12566888, probably play important roles in prasugrel pharmacodynamics PMID: 23859572
17. additional exonic variants in PEAR1 that may also determine variability in platelet aggregation, were identified. PMID: 23704978
18. A-allele carriers of rs12041331 in the platelet endothelial aggregation receptor-1 (PEAR1) gene were more likely to experience a cardiovascular event or death compared with GG homozygotes PMID: 23392654
19. PEAR1 attenuates megakaryopoiesis via control of the PI3K/PTEN pathway. PMID: 23667054
20. A specific intronic PEAR1 gene variant is ientified that associated with greater platelet aggregability and protein expression. PMID: 21791418
21. Observational study and genome-wide association study of gene-disease association. (HuGE Navigator) PMID: 20526338
22. PEAR1 is a novel platelet receptor that signals secondary to alpha(IIb)beta(3)-mediated platelet-platelet contacts PMID: 15851471
23. C allele of PEAR1 (Platelet endothelial aggregation receptor-1)was generally associated in both ethnic groups with increased aggregation of native platelets PMID: 18511696
24. Observational study of gene-disease association. (HuGE Navigator) PMID: 19429868
25. Observational study of gene-disease association. (HuGE Navigator) PMID: 18511696
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亞細胞定位：

Cell membrane; Single-pass membrane protein.
蛋白家族：

MEGF family
組織特異性：

Expressed in umbilical vein endothelial cells and platelets (at protein level). Expressed in heart, kidney, skeletal muscle, pancreas, ovary, breast, lung, brain cortex, hypothalamus, spinal cord, dorsal root ganglion, endothelial cells of umbilical cord
數據庫鏈接：

HGNC: 33631

OMIM: 610278

KEGG: hsa:375033

STRING: 9606.ENSP00000292357

UniGene: Hs.142003

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