NIT2
NIT2，即腈水解酶家族成員2，別名HEL-S-8a。NIT2屬于腈水解酶超家族成員，含有保守的腈水解酶結構域，是一種ω-酰胺酶。NIT2與含溴結構域蛋白1（BRD1）相互作用，抑制BRD1/HBO1介導的組蛋白H3K14乙酰化和氧化磷酸化（OXPHOS）基因表達，從而抑制化療耐藥性。NIT2是一種潛在的腫瘤抑制因子，可誘導細胞周期停滯，其表達與H3K14ac和OXPHOS呈負相關，與胃癌患者的化療反應和預后呈正相關。NIT2的缺失或低表達導致胃癌細胞系、患者來源的胃癌類器官以及異種移植腫瘤對5-FU耐藥。
熱銷產品
NIT2 Antibody (CSB-PA882075LA01HU)
驗證數據
Western blot
All lanes: NIT2 antibody at 3μg/ml
Lane 1: Mouse heart tissue
Lane 2: A549 whole cell lysate
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 31 kDa
Observed band size: 31 kDa
NIT2 Antibodies
NIT2 for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 種屬反應性 | 應用類型 |
|---|---|---|---|
| CSB-PA015823GA01HU | NIT2 Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-PA912806 | NIT2 Antibody | Human,Mouse | ELISA,WB,IHC |
| CSB-PA187627 | NIT2 Antibody | Human,Mouse | ELISA,WB,IHC |
| CSB-PA882075LA01HU | NIT2 Antibody | Human, Mouse | ELISA, WB |
| CSB-PA882075LB01HU | NIT2 Antibody, HRP conjugated | Human | ELISA |
| CSB-PA882075LC01HU | NIT2 Antibody, FITC conjugated | Human | |
| CSB-PA882075LD01HU | NIT2 Antibody, Biotin conjugated | Human | ELISA |
NIT2 Proteins
NIT2 Proteins for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP882075HU CSB-EP882075HU CSB-BP882075HU CSB-MP882075HU CSB-EP882075HU-B |
Recombinant Human Omega-amidase NIT2 (NIT2) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
