NIT2 Antibody
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中文名稱：NIT2兔多克隆抗體
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貨號：CSB-PA187627
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規格：￥1100
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圖片：
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The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using CSB-PA187627(NIT2 Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: ×200) -
The image on the left is immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using CSB-PA187627(NIT2 Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: ×200) -
Gel: 10%SDS-PAGE, Lysate: 40 μg, Lane 1-3: Mouse liver tissue, Mouse kidney tissue, RAW264.7 cells, Primary antibody: CSB-PA187627(NIT2 Antibody) at dilution 1/950, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 90 seconds
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其他：
產品詳情
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Uniprot No.：
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基因名：
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別名：CUA002 antibody; MGC111199 antibody; NIT 2 antibody; Nit protein 2 antibody; NIT2 antibody; NIT2_HUMAN antibody; Nitrilase family member 2 antibody; Nitrilase homolog 2 antibody; Omega amidase NIT2 antibody; Omega-amidase NIT2 antibody
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宿主：Rabbit
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反應種屬：Human,Mouse
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免疫原：Synthetic peptide of Human NIT2
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免疫原種屬：Homo sapiens (Human)
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標記方式：Non-conjugated
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抗體亞型：IgG
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純化方式：Antigen affinity purification
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
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產品提供形式：Liquid
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應用范圍：ELISA,WB,IHC
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推薦稀釋比：
Application Recommended Dilution ELISA 1:2000-1:10000 WB 1:1000-1:5000 IHC 1:50-1:200 -
Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：Has omega-amidase activity. The role of omega-amidase is to remove potentially toxic intermediates by converting 2-oxoglutaramate and 2-oxosuccinamate to biologically useful 2-oxoglutarate and oxaloacetate, respectively.
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基因功能參考文獻：
- Downregulation of NIT2 inhibits colon cancer cell proliferation and induces cell cycle arrest through the caspase-3 and PARP pathways PMID: 25738796
- Human NIT1/2 are not involved in the metabolism of vildagliptin. PMID: 25008847
- The activity and substrate specificity of human Nit2 was determined with alpha-ketoglutaramate and succinamate as substrates. PMID: 22674578
- Genotype analysis in 4 types of tumor tissue showed allelic imbalance surrounding NIT2 locus; results show that NIT2 plays an important role in cell growth inhibition & links to malignancies, suggesting Nit2 may be a potential tumor suppressor candidate PMID: 17488281
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亞細胞定位：Cytoplasm.
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蛋白家族：Carbon-nitrogen hydrolase superfamily, NIT1/NIT2 family
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組織特異性：Detected in fetal brain (at protein level). Ubiquitous. Detected in heart, brain, placenta, lung, liver, skeletal muscle, kidney, pancreas, prostate, spleen, thymus, prostate, testis, ovary, small intestine and colon.
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數據庫鏈接：
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