MICU1
MICU1，全稱為線粒體鈣攝取蛋白1，是一種位于線粒體內(nèi)膜的關(guān)鍵調(diào)節(jié)蛋白。該蛋白參與維持細(xì)胞內(nèi)鈣穩(wěn)態(tài)，通過與MCU通道蛋白相互作用，形成“分子門控”機(jī)制，控制鈣離子進(jìn)入線粒體的閾值，防止鈣超載導(dǎo)致的細(xì)胞損傷。MICU1蛋白的主要作用位點(diǎn)為線粒體基質(zhì)，其功能包括調(diào)節(jié)能量代謝、細(xì)胞凋亡信號(hào)傳導(dǎo)及活性氧（ROS）平衡。MICU1蛋白的常見別名有CALC、EFHA3、FLJ12684等。MICU1蛋白與多種疾病相關(guān)，包括神經(jīng)退行性疾病（如阿爾茨海默病）、心血管疾病和癌癥等。目前，針對(duì)MICU1蛋白相關(guān)疾病的藥物研發(fā)尚處于探索階段，但已有研究表明，通過調(diào)控MICU1蛋白的表達(dá)和功能，有望為相關(guān)疾病的治療提供新的策略。例如，有研究指出，抑制肝臟MCU可以緩解肥胖、肝臟脂肪變性及高血糖，這為畜禽相關(guān)疾病的防治提供了新的手段。
熱銷產(chǎn)品
MICU1 Antibody (CSB-PA860652LA01HU)
驗(yàn)證數(shù)據(jù)
Western Blot
Positive WB detected in: A549 whole cell lysate
All lanes: MICU1 antibody at 3.2µg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 55, 46, 33, 32 kDa
Observed band size: 55 kDa
IHC image of CSB-PA860652LA01HU diluted at 1:400 and staining in paraffin-embedded human adrenal gland tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
MICU1 Monoclonal Antibody (CSB-MA080225)
驗(yàn)證數(shù)據(jù)
Immunohistochemical analysis of paraffin-embedded Human Lung Carcinoma using MICU1 Monoclonal Antibody.
Western blot analysis of 1) MCF7, 2) Mouse Brain Tissue, 3) Rat Brain Tissue using MICU1 Monoclonal Antibody.
MICU1 Antibodies
MICU1 for Human, Mouse, Rat
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-MA080225 | MICU1 Monoclonal Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
MICU1 for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA860652LA01HU | MICU1 Antibody | Human | ELISA, WB, IHC |
| CSB-PA860652LB01HU | MICU1 Antibody, HRP conjugated | Human | ELISA |
| CSB-PA860652LC01HU | MICU1 Antibody, FITC conjugated | Human | |
| CSB-PA860652LD01HU | MICU1 Antibody, Biotin conjugated | Human | ELISA |
MICU1 Proteins
MICU1 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP860652HU CSB-EP860652HU CSB-BP860652HU CSB-MP860652HU CSB-EP860652HU-B |
Recombinant Human Calcium uptake protein 1, mitochondrial (MICU1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
