MICU1 Antibody, HRP conjugated

說明書

中文名稱：

MICU1兔多克隆抗體, HRP偶聯
貨號：

CSB-PA860652LB01HU
規格：

￥880
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) MICU1 Polyclonal antibody
Uniprot No.：

Q9BPX6
基因名：

MICU1
別名：

Allergen Hom s 4 antibody; ara CALC antibody; atopy related autoantigen antibody; atopy related autoantigen CALC antibody; Atopy-related autoantigen CALC antibody; CALC antibody; calcium binding atopy related autoantigen 1 antibody; Calcium uptake protein 1 antibody; calcium uptake protein 1, mitochondrial antibody; Calcium-binding atopy-related autoantigen 1 antibody; CBARA1 antibody; EFHA3 antibody; FLJ12684 antibody; MICU1 antibody; MICU1_HUMAN antibody; mitochondrial antibody; mitochondrial calcium uptake 1 antibody; MPXPS antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human Calcium uptake protein 1, mitochondrial protein (55-191AA)
免疫原種屬：

Homo sapiens (Human)
標記方式：

HRP
克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA
Protocols：

ELISA Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Key regulator of mitochondrial calcium uniporter (MCU) that senses calcium level via its EF-hand domains. MICU1 and MICU2 form a disulfide-linked heterodimer that stimulates and inhibits MCU activity, depending on the concentration of calcium. MICU1 acts both as an activator or inhibitor of mitochondrial calcium uptake. Acts as a gatekeeper of MCU at low concentration of calcium, preventing channel opening. Enhances MCU opening at high calcium concentration, allowing a rapid response of mitochondria to calcium signals generated in the cytoplasm. Regulates glucose-dependent insulin secretion in pancreatic beta-cells by regulating mitochondrial calcium uptake. Induces T-helper 1-mediated autoreactivity, which is accompanied by the release of IFNG.
基因功能參考文獻：
1. FOXD1-dependent MICU1 expression regulates mitochondrial activity and cell differentiation PMID: 30158529
2. drives aberrant metabolism that fuels aerobic glycolysis and chemoresistance in ovarian cancer PMID: 28530221
3. the absence of MICU1, both Mn(2+) and Ca(2+) can pass through the uniporter, as evidenced by mitochondrial Mn(2+) uptake assays, mitochondrial membrane potential measurements, and mitoplast electrophysiology. PMID: 30082385
4. Mitochondrial Ca(2+) uptake is controlled by protein arginine methyl transferase 1 that asymmetrically methylates MICU1, resulting in decreased Ca(2+) sensitivity. UCP2/3 normalize Ca(2+) sensitivity of methylated MICU1 and, thus, re-establish mitochondrial Ca(2+) uptake activity. PMID: 27642082
5. MICU2 restricts spatial crosstalk between InsP3R and MCU channels by regulating threshold and gain of MICU1-mediated inhibition and activation of MCU. PMID: 29241542
6. study concludes that cooperative, high-affinity interaction of the MICU1-MICU2 complex with Ca(2+) serves as an on-off switch, leading to a tightly controlled channel, capable of responding directly to cytosolic Ca(2+) signals PMID: 28615291
7. MICU1 serves as a signal-noise discriminator in mitochondrial calcium signalling, limiting the energetic costs of mitochondrial Ca2+ signalling which may undermine oxidative phosphorylation, especially in tissues with highly dynamic energetic demands. PMID: 28132899
8. Results showed that the SNP on EF-hand Ca2+ binding domains of MICU1 gene had no effect in phenotypic characters of bipolar disorder patients PMID: 27297032
9. Our experiments provide novel details about how MCU/EMRE is regulated by MICU1 and an original approach to investigate MCU/EMRE activation in intact cells. PMID: 26489515
10. Data show that ribosomal protein S3 (RPS3) knockdown decreased mitochondrial calcium uptake 1 protein (MICU1) expression. PMID: 26336993
11. Loss of heterozygosity of MICU1 gene on chromosome 10q is associated with pancreatic cancer. PMID: 25824785
12. Expression of MICU1 mutants lacking functional Ca2+-binding sites leads to a striking loss of Ca2+ uptake in HEK293 cells. PMID: 24503055
13. MICU1 EF hands determine MCU activity, but not binding. PMID: 24332854
14. MICU1 and MICU2 have roles in tuning the mitochondrial Ca2+ uniporter by exerting opposite effects on MCU activity PMID: 24560927
15. Loss-of-function mutations in MICU1 cause a brain and muscle disorder linked to primary alterations in mitochondrial calcium signaling. PMID: 24336167
16. Prolonged MICU1 loss leads to an adaptive increase in matrix Ca(2+) binding, yet cells show impaired oxidative metabolism and sensitization to Ca(2+) overload. PMID: 23747253
17. CBARA1 is a marker for undifferentiated human embryonic stem cells that plays a role in maintaining stemness, cell cycle progression, and proliferation. PMID: 23667653
18. MICU1 is a novel regulator of the machinery in cancer cells that prevents apoptosis. PMID: 23615904
19. MICU1 is a gatekeeper of mitochondrial calcium uniporter-mediated Ca(2 )uptake that is essential to prevent [Ca(2 )]overload and associated stress. PMID: 23101630
20. the crucial role of MICU1 and MCU in mitochondrial Ca(2+) uptake in pancreatic beta-cells and their involvement in the positive feedback required for sustained insulin secretion. PMID: 22904319
21. MICU1 physically interacts with MCU, a principal component of the mitochondrial calcium uniporter. PMID: 21685886
22. MICU1 represents the founding member of a set of proteins required for high-capacity mitochondrial calcium uptake PMID: 20693986
23. MICU1 (CBARA1) is an EF-hand containing protein associated with the mitochondrial inner membrane. It is required for mitochondrial calcium uptake in HeLa cells. PMID: 20693986
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相關疾病：

Myopathy with extrapyramidal signs (MPXPS)
亞細胞定位：

Mitochondrion inner membrane; Single-pass membrane protein. Mitochondrion intermembrane space.
蛋白家族：

MICU1 family, MICU1 subfamily
組織特異性：

Expressed in epithelial cell lines. Strongly expressed in epidermal keratinocytes and dermal endothelial cells.
數據庫鏈接：

HGNC: 1530

OMIM: 605084

KEGG: hsa:10367

STRING: 9606.ENSP00000354415

UniGene: Hs.524367

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