KIF18A
KIF18A，即驅動蛋白家族成員18A。別名CD319。它在細胞內主要位于細胞質和細胞核中，由898個氨基酸殘基組成，分子量約為100kDa。KIF18A的作用機制涉及其作為kinesin-8家族成員，依靠水解ATP釋放的能量，以微管為軌道向正極方向運動，調控微管的動態不穩定性，發揮類似于微管解聚酶的活性。KIF18A對維持染色體穩定性和控制有絲分裂過程中的染色體排列至關重要，其功能異常可能導致細胞轉化和致癌。多項研究表明，KIF18A在多種癌細胞中具有高表達，與乳腺癌、透明細胞腎癌和結腸癌患者的預后相關，參與肝細胞癌的侵襲和轉移，并與細胞增殖、腫瘤分期和多發性腫瘤的預后相關。KIF18A是一種可能的癌癥預后生物標志物，也是抗有絲分裂治療的潛在靶點。
熱銷產品
KIF18A Antibody (CSB-PA847753LA01HU)
驗證數據
Immunofluorescence staining of A549 cells with CSB-PA847753LA01HU at 1:100, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
KIF18A Antibodies
KIF18A for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 種屬反應性 | 應用類型 |
|---|---|---|---|
| CSB-PA012315GA01HU | KIF18A Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-PA847753LA01HU | KIF18A Antibody | Human | ELISA, IF |
| CSB-PA847753LB01HU | KIF18A Antibody, HRP conjugated | Human | ELISA |
| CSB-PA847753LC01HU | KIF18A Antibody, FITC conjugated | Human | |
| CSB-PA847753LD01HU | KIF18A Antibody, Biotin conjugated | Human | ELISA |
KIF18A Proteins
KIF18A Proteins for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP847753HU CSB-EP847753HU CSB-BP847753HU CSB-MP847753HU CSB-EP847753HU-B |
Recombinant Human Kinesin-like protein KIF18A (KIF18A), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
